COBRE for Perinatal Biology

COBRE 围产期生物学

• 批准号: 9270050
• 负责人: SUNIL K SHAW
• 金额: $ 81.29万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-18 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9270050
• 关键词: 1-Phosphatidylinositol 3-Kinase; Adolescent; Adult; Aging; Alzheimer' s Disease; Antibodies; Antigens; Award; Biology; Cardiac; Cardiac Myocytes; Cardiopulmonary; Centers of Research Excellence; Child; Collaborations; Core Facility; Creativeness; Development; Diagnosis; Disease; Elements; Embryonic Development; Environment; Equipment; Erythrocytes; Extramural Activities; Faculty; Fostering; Goals; Grant; Heart; Hospitals; Human; Immune response; Infant; Interdisciplinary Study; Joints; Leadership; Life; Malaria; Malaria Vaccines; Malignant Neoplasms; Mentors; Newborn Infant; Parasites; Pathogenesis; Pathway interactions; Patients; Perinatal; Phase; Pre-Eclampsia; Prealbumin; Premature Birth; Proteins; Proteomics; Regulatory Pathway; Reproductive Biology; Research; Research Personnel; Resistance; Resources; Role; Science; Scientist; Signal Transduction; Stem cells; Technology; Vaccinated; Vaccines; Woman; Work; adult stem cell; base; career; cohort; fetal; in vitro Bioassay; injured; insight; instrumentation; interdisciplinary collaboration; malaria infection; mouse model; novel; novel therapeutics; operation; programs; public health relevance; repaired; restoration; success

 DESCRIPTION (provided by applicant): The scientific aims of our COBRE have been to increase our understanding of reproductive biology and cardiopulmonary development, to enhance our understanding of perinatal diseases, like preeclampsia and preterm birth, and to develop new opportunities for novel therapeutic strategies. Our research focus during Phase I and Phase II has been driven by recognition that the fundamental mechanisms that regulate embryonic development, cancer, and aging are overlapping. The success of our projects has been enhanced by the common view that looking through this "prism of development" provides unique experimental leverage and testable hypotheses for how regulatory pathways are governed later in life. The programmatic aims of the COBRE have been to create a Center for Perinatal Biology providing scientific and career mentoring to junior faculty within an environment fostering creativity and transdisciplinary collaboration. During Phase III of the COBRE for Perinatal Biology, our objectives will be: 1) continued support of COBRE-related activities; 2) transition the Center to sustainability; and 3) enhance perinatal and developmental research at Women & Infants Hospital. Resources for the Research Core programs will be used to upgrade existing instrumentation to enhance our research sophistication. The Pilot Grants Program associated with the Phase-III COBRE will be used to stimulate collaborative research efforts that will contribute to joint applications among the investigators and sustaining resources for the Core Facilities. The Specific Aims we have identified to accomplish these goals are: Specific Aim 1: Provide Overall Leadership supporting the Administrative Core's ability to manage the operations and to transition the COBRE for Perinatal Biology into a sustainable Center for Perinatal Biology toward long-term sustainability. Specific Aim 2: Develop a sustainable, state-of-the-art Research Core that maximizes the use and impact of contemporary approaches, equipment, and technology for Perinatal Research. Specific Aim 3: Utilize Pilot Grants Program resources to catalyze multi-disciplinary research leading to additional extramural awards in Perinatal Research.

 描述（由适用提供）：我们的鞋底的科学目的是增加我们对生殖生物学和心肺发展的理解，以增强我们对围产期疾病的理解，例如先兆子痫和早产，并为新颖的治疗策略开发新的机会。我们在第一阶段和第二阶段的研究重点是由认识到调节胚胎发育，癌症和衰老的基本机制的驱动。共同观点通过这种“发展的棱镜”来增强了我们项目的成功，这为监管途径在以后的生活中如何治理提供了独特的实验性杠杆和可检验的假设。该家土的程序化目标是为围产期生物学创建一个中心，为促进创造力和跨学科合作的环境中的初级教师提供科学和职业心态。在围产期生物学的毛虫的第三阶段期间，我们的目标是：1）持续支持与鞋垫相关的活动； 2）过渡到可持续性； 3）增强女性和婴儿医院的围产期和发育研究。研究核心计划的资源将用于升级现有的仪器，以增强我们的研究精致。与III期相关的试点赠款计划将用于刺激协作研究工作，这将有助于研究人员之间的共同应用并维持资源 用于核心设施。我们确定的实现这些目标的具体目标是：具体目标1：提供总体领导，支持行政核心管理运营并将围绕围产期生物学的毛cr的能力转变为围产期生物学的可持续性中心，以实现长期可持续性。具体目标2：开发可持续的，最先进的研究核心，该核心最大程度地利用了当代方法，设备和技术对围产期研究的使用和影响。特定目的3：利用飞行员授予计划资源来催化多学科研究，从而在围产期研究中获得额外的壁外奖励。