Increasing Activity Post-Kidney Transplant with SystemCHANGE

通过 SystemCHANGE 增加肾移植后的活动

基本信息

批准号：
9357673
负责人：
Tara O'Brien
金额：
$ 12.94万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-26 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9357673
关键词：
Accelerometer Achievement Activities of Daily Living Address Adult Age Behavioral Blood Pressure Body Weight decreased Body mass index Cardiovascular Diseases Cardiovascular system Case Manager Cause of Death Cessation of life Chronic Disease Chronically Ill Clinic Clinical Trials Comorbidity Complement Control Groups Data Data Reporting Data Set Development Effectiveness Elderly Event Funding Opportunities Future General Population Goals Grant Habits Health Health Care Costs Health Promotion Healthcare Heart Rate Incidence Individual Informatics Institutes Intervention K-Series Research Career Programs Kidney Transplantation Kilogram Lead Life Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Monitor Obesity Organ Transplantation Outcome Patients Pattern Perception Physical activity Pilot Projects Population Populations at Risk Positioning Attribute Quality of life Randomized Clinical Trials Recruitment Activity Research Research Personnel Research Project Grants Research Training Risk SF-12 Scientist Secure Self Management Site Solid System Techniques Technology Training Training Programs Transplant Recipients Transplantation Travel United States National Institutes of Health Visual Weight Gain Work base career career development disorder prevention efficacy testing experience experimental study frailty group intervention hands on research improved improved outcome interest knowledge base mHealth medication compliance meetings peer prevent sedentary lifestyle skills stroke survivor symposium tool usability waist circumference

项目摘要

Abstract Inactivity is a common problem among older kidney transplant recipients (KTRs) and is associated with their high incidence of obesity and cardiovascular problems which are the leading cause of death for KTRs. However, the combination of SystemCHANGETM + activity trackers holds promise for increasing activity. The short-term goals of this Mentored Patient-Oriented Research Career Development Award (K23) are to implement these interventions and obtain preliminary data on older adult KTRs. Sixty KTRs age 65 and older will be recruited from a Mid-South transplant center to determine: (I) if perceptions (usability, sustainability, and acceptability) of activity tracker use differ for older adult KTRs participating in a SystemCHANGETM intervention compared to a control group at 1, 2, 3, 6, & 12 months and (II) the degree to which a SystemCHANGE™ + activity tracker intervention improves physical activity (steps per day), functional ability, health outcomes (blood pressure, heart rate, waist circumference, and body mass index) and quality of life for older adult KTRs from baseline to 3, 6, & 12 months compared to a control group using only activity trackers . The long-term goal is to develop the candidate as an independent investigator prepared to lead randomized clinical trials focused on maximizing physical activity among older chronically ill adults. The proposed training is in line with NINR- supported initiatives and represents a logical progression from the candidate's prior research training. Career development objectives are to: (1) gain expertise with the theoretically-based SystemCHANGE™ intervention and work with informatics experts, (2) develop a stronger knowledge base for the responsible conduct of scientific research and the field of kidney transplantation, (3) develop proficiency in the use of statistical techniques for the analysis of continuously monitored data (i.e., daily steps taken), (4) develop skills in the conduct of randomized clinical trials (RCT) at the core of the proposed study, (5) actively engage in the ongoing RCT study of mentors called the Medication Adherence Given Individual Change (MAGIC) and observe the case manager at the transplant clinic, (6) implement the proposed K23 research project, and (7) analyze and use preliminary data from the K23 pilot study to prepare an “R01”grant to test the efficacy of personalized mobile health interventions for physical activity in a multi-site RCT. Career objectives will be accomplished through didactic courses; participation in national conferences and institutes; and hands-on research training under the mentorship of an accomplished team of scientists in the field of kidney transplantation (Hathaway and Russell), SystemCHANGETM (Moore and Russell), physical activity in older adults (Resnick), mobile activity trackers and the integration of large monitoring data sets (Ertin), clinical trials (Russell), and quantitative methods (Hathaway). The skills, experience, and data gained from this career development award will position the candidate to advance behavioral self-management interventions focused on maximizing physical activity for older chronically ill adults.

抽象的不活动是较老的肾脏肾脏移植受者（KTR）的常见问题，并且与其相关肥胖和心血管问题的高发病率是KTR的主要死亡原因。但是，System Changetm +活动跟踪器的组合有望增加活动这项受过指导的注重患者研究职业发展奖（K23）的短期目标是。实施InterventIntint获得前成人KTR的初步数据。将从中南透明中心招募以确定：（i）percections（可用性，可持续性和和可接受性追踪器的使用情况不同，参与SystemChange InterventionTionTM的老年人KTR不同与1、2、3、6和12个月的对照组相比，以及（ii）SystemChange™ +的程度活动跟踪器干预改善体育锻炼（每天的步骤），功能能力，健康结果（血液压力，心率，腰围和体重指数）和老年人KTR的生活质量与仅使用活动跟踪器的对照组相比，基线至3、6，＆＆＆＆＆＆＆＆12个月。将候选人发展为准备领导关注的随机临床的Aspentent研究者最大程度地提高年龄较大的成年人的体育锻炼。支持候选人的职业培训中的计划和压制者取得了逻辑上的进步。开发目标是：（1）基于理论的SystemChange™Intervuation获得专业知识（2）与信息学专家合作，为负责任的行为建立更强的知识库科学研究和肾脏移植领域，（3）在使用统计学方面发展有利分析连续监控数据的技术（即每天采取的每日步骤），（4）发展技能在支撑研究的核心中进行随机临床试验（RCT），（5）积极参与鉴于个人变化（魔术）和在透明诊所观察案件经理，（6）实施支架的K23研究项目，并（7）分析和使用K23试点研究的初步数据来准备“ R01”赠款以测试在多站点RCT中进行体育活动的个性化移动健康干预措施将是职业目标。通过教学课程和实践学院进行教学；在肾脏领域的一组科学家团队的指导下进行的研究培训移植（Hathaway和Russell），System Changetm（Moore和Russell），年龄较大的体育活动成人（Resnick），移动活动跟踪器和大型监控数据集（ERTIN）的集成，临床试验（Russell）和定量方法（Hathaway）。开发奖将使候选人定位以提高行为自我管理干预措施的重点在最大化体育活动时，所有成年人都会长期生病。