National Biomedical Center for Advanced ESR Technology (ACERT)

国家生物医学先进ESR技术中心（ACERT）

• 批准号: 9208899
• 负责人: Jack H Freed
• 金额: $ 152.62万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9208899
• 关键词: Acquired Immunodeficiency Syndrome; Address; Advertising; Alzheimer' s Disease; Area; Bacterial Infections; Biological; Biomedical Research; Collaborations; Computing Methodologies; Depressive disorder; Development; Disease; Ebola virus; Educational workshop; Electron Spin Resonance Spectroscopy; Eye diseases; Frequencies; Heart Diseases; Hypersensitivity; Infertility; Inflammation; Laboratories; Malignant Neoplasms; Methodology; Methods; Modernization; Parkinson Disease; Physiologic pulse; Publishing; Research; Research Personnel; Running; Sampling; Schizophrenia; Scientist; Services; Severe Acute Respiratory Syndrome; Technology; Training; United States National Institutes of Health; Virus Diseases; Wernicke Encephalopathy; combat; improved; nervous system disorder; new technology; protein structure; research and development; synergism

PROJECT SUMMARY/ABSTRACT: This is a P41 renewal proposal to continue the National Biomedical Center for Advance ESR Technology (ACERT). Four principal areas of Technology Research and Development (TR&D) will be emphasized. They consist of 1) High-Sensitivity Pulse Dipolar ESR Spectroscopy and 2D-FT ESR from X to Ka Band; 2) Electron Spin Resonance with Ultra-High Sensitivity for Very Small Biological Samples; 3) Developments in High Frequency ESR, and 4) Improved Computational Methods for ESR Analysis and Spectral Processing. Extensive Driven Biomedical Projects and other collaborations with biomedical researchers will greatly benefit from these TR&Ds, which in turn are driven by the DBP needs for the new and improved ESR technologies. Thus, there is an important synergism amongst the TR&Ds and the DBPs. The technologies being developed at ACERT are in many respects unique in the world. The extensive DBP's and collaborative/service projects at ACERT will continue to bring these modern ESR methods to the forefront of biomedical research, especially as the additional challenges are addressed in the TR&D's. This includes our plans to increase spectral sensitivity in our ACERT spectrometers, for which the demands continue to grow. The plans for dissemination and training address the need to bring these new technologies to other laboratories in the USA and elsewhere in addition to making the facilities available to outside scientists, publishing and advertising the results of the Center and running workshops on the new methodologies.

项目摘要/摘要： 这是一个P41更新提案，旨在继续国家生物医学高级ESR技术中心 （Acert）。将强调技术研发（TR＆D）的四个主要领域。他们 包括1）高敏感性脉冲偶极ESR光谱和从X到KA频段的2D-FT ESR； 2）电子 对非常小的生物样品具有超高敏感性的自旋共振； 3）高度发展 频率ESR和4）改进了用于ESR分析和光谱处理的计算方法。 广泛的驱动生物医学项目和与生物医学研究人员的其他合作将极大地受益 从这些TR＆D中，这些TR＆D反过来又由DBP需求驱动了新的和改进的ESR技术。 因此，TR＆D和DBP之间存在着重要的协同作用。开发的技术 在阿卡特（Acert）在世界上在许多方面都是独一无二的。广泛的DBP和协作/服务项目 ACERT将继续将这些现代ESR方法带到生物医学研究的最前沿，尤其是 TR＆D的额外挑战已解决。这包括我们提高光谱敏感性的计划 在我们的ACERT光谱仪中，需求继续增长。传播计划和 培训解决了将这些新技术带到美国和其他地方的其他实验室的需求 除了向外部科学家提供这些设施，发布和宣传其结果 中心并在新方法上运行研讨会。