Using tDCS to Promote Speech Motor Learning

使用 tDCS 促进言语运动学习

基本信息

批准号：
9291454
负责人：
Adam Buchwald
金额：
$ 17.26万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9291454
关键词：
Address Affect Anodes Apraxias Area Basic Science Behavior Therapy Communication Development Development Plans Disease Environment Family Foundations Goals Grant Health Care Costs Human Impairment Individual Intervention Intervention Studies Knowledge Language Lead Learning Left Limb structure Literature Mentors Mission Motor Neurocognitive Procedures Production Public Health Quality of life Recovery Rehabilitation therapy Reporting Research Research Personnel Residual state Speech Stroke Structure Techniques Testing Time Training Treatment Efficacy Treatment Protocols Treatment outcome United States United States National Institutes of Health Work base career development chronic stroke clinical investigation cost efficient disability effective intervention improved improved outcome innovation motor control motor learning motor rehabilitation neuroregulation novel programs public health relevance research and development skills social sound stroke rehabilitation stroke survivor stroke treatment targeted treatment therapy development translational research program

项目摘要

DESCRIPTION (provided by applicant): Stroke is a leading cause of disability in the United States, frequently leading to speech impairment that creates barriers to participation in professional, social, and family settings. While recovery can be promoted with speech treatment targeted to the specific locus of impairment, improvement remains modest and typically requires a large amount of therapy which contributes to rising health care costs. Thus, there is a need for time- and cost-efficient interventions to expedite and enhance recovery. Recent studies from related domains of stroke rehabilitation (limb motor control and language) indicate that non-invasive neurostimulation such as transcranial direct current stimulation (tDCS) may enhance treatment outcomes, but the potential for improving outcomes specifically for speech impairment has not yet been explored. The career development and research plans of the proposed project will allow the candidate to establish a T2 translational research program as an independent investigator to systematically explore the potential for tDCS to enhance treatment outcomes in individuals with stroke-induced speech impairment. The career development plan will help expand the candidate's research program to include basic and clinical investigations of tDCS-induced plasticity and its potential to facilitate speech motor learning in unimpaired and impaired speakers. The research plan provides an empirical foundation for this research program by investigating the interaction of tDCS and practice-induced speech motor learning. The long-term goal of this research is to develop effective intervention approaches for individuals with acquired speech impairment by combining theoretically-guided intervention with treatment-enhancing neuromodulation techniques. The main objective of this proposal is to establish a best-practice approach for using tDCS to support speech motor learning. The central hypothesis of this proposal is that non-invasive neuromodulation can enhance speech motor learning, including treatment outcomes for targeted interventions for acquired speech impairment. The rationale for the proposed research is that understanding the interaction between neuromodulation and speech motor learning may help determine the most effective approach to enhancing stroke treatment outcomes while extending our basic science knowledge of the relationship between speech and non-speech motor learning. The proposed research is significant because it will enable the development of intervention procedures that maximize recovery from acquired speech impairment, combining targeted therapy with tDCS to unmask the residual capacity for cortical plasticity in chronic stroke survivors. The proposed research is relevant to that part of NIH's mission that pertains to developing fundamental knowledge that will potentially help to reduce the burdens of human disability.

描述（由申请人提供）：中风是美国残疾的主要原因，经常导致言语障碍，从而给参与职业、社交和家庭环境造成障碍，而针对特定的言语治疗可以促进康复。损伤部位的改善仍然有限，通常需要大量治疗，这会导致医疗费用上升，因此，需要采取时间和成本有效的干预措施来加速和促进中风相关领域的康复。（肢体运动控制与康复）语言）表明，诸如经颅直流电刺激（tDCS）之类的非侵入性神经刺激可能会增强治疗效果，但尚未探索专门针对言语障碍改善效果的潜力。拟议项目的职业发展和研究计划将允许。候选人作为独立研究者建立 T2 转化研究计划，系统地探索 tDCS 增强中风引起的言语障碍患者治疗效果的潜力。职业发展计划将有助于扩大候选人的研究计划，包括基础和临床研究。的tDCS 诱导的可塑性及其促进未受损和受损患者言语运动学习的潜力该研究计划通过调查经颅直流电刺激（tDCS）和练习诱发的言语运动学习的相互作用，为该研究项目提供了实证基础。该研究的长期目标是为患有后天障碍的个体开发有效的干预方法。该提案的主要目标是建立一种使用 tDCS 支持言语运动学习的最佳实践方法。可以增强言语运动学习，包括针对获得性言语障碍进行针对性干预的治疗结果。拟议研究的基本原理是，了解神经调节和言语运动学习之间的相互作用可能有助于确定增强中风治疗结果的最有效方法，同时扩展我们的基本治疗效果。的科学知识拟议的研究意义重大，因为它将能够开发出最大限度地从获得性言语障碍中恢复的干预程序，将靶向治疗与经颅直流电刺激（tDCS）相结合，以揭示慢性中风幸存者的皮质可塑性的残余能力。拟议的研究与 NIH 使命的一部分相关，即开发可能有助于减轻人类残疾负担的基础知识。