Mentoring and Research on Neurobiological Markers of Clinical Outcomes in Depression

抑郁症临床结果神经生物学标志物的指导和研究

• 批准号: 9343063
• 负责人: Warren D Taylor
• 金额: $ 17.34万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9343063
• 关键词: Address; Affect; Aging; Alzheimer' s Disease; Amyloid; Amyloid deposition; Amyloidosis; Antidepressive Agents; Applications Grants; Area; Award; Awareness; Binding; Biological Markers; Blinded; Blood Vessels; Brain; Clinical; Clinical Markers; Cognition; Cognitive; Complement; Data; Data Set; Dementia; Depressed mood; Development; Development Plans; Doctor of Philosophy; Educational workshop; Elderly; Emotional; Escitalopram; Exhibits; Faculty; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Goals; Image; Image Analysis; Impaired cognition; Individual; Lesion; Link; Magnetic Resonance Imaging; Measures; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modeling; Molecular; Multimodal Imaging; National Institute of Mental Health; Neurobiology; Neurotransmitter Receptor; Outcome; Parents; Pathologic; Pathology; Pattern; Phenotype; Pilot Projects; Plasma; Play; Population; Positron-Emission Tomography; Process; Publishing; Recruitment Activity; Reporting; Research; Research Methodology; Research Personnel; Research Training; Resources; Risk; Role; Strategic Planning; Symptoms; Testing; Time; Training; Training Programs; Treatment outcome; Universities; Vascular Diseases; Work; adverse outcome; amyloid peptide; brain metabolism; career; career development; clinical effect; clinical phenotype; cognitive performance; depressive symptoms; experience; geriatric depression; interest; magnetic resonance imaging biomarker; medical schools; middle age; mood symptom; negative affect; neural circuit; neuroimaging marker; neuropathology; novel; parent grant; patient oriented research; placebo controlled study; predicting response; programs; radioligand; relating to nervous system; research and development; response; skills; success; symptomatology; treatment response; vascular depression

This is a new submission for a K24 Midcareer Investigator Award in Patient-Oriented Research. The overarching objective of this proposal is to allow the Candidate, Warren D. Taylor, MD, to 1) develop expertise in PET imaging and 2) obtain skills and experience in mentoring junior researchers. This will extend his past work examining biomarkers of clinical outcomes in depression into cellular and molecular measures while mentoring new investigators on biomarker approaches examining important clinical outcomes. To achieve these goals, the Career Development Plan provides for training in PET imaging methodology, methods for analyzing PET imaging data, and methods for multimodal imaging analyses combining PET and MRI data. His mentorship skills will be enhanced through by serving as faculty for local and national mentoring workshops, formal training, and work to develop a research training program. Supporting these goals, the Mentoring Plan focuses on junior investigators in patient-oriented research with interests in depression. Utilizing multiple Vanderbilt resources to identify and support these trainees, the Candidate will provide hands-on training in research methodology with the goal of trainees preparing publishable scientific reports and entry-level grant applications. Extensive institutional resources at Vanderbilt will augment experiences provided by the Candidate. Finally, the Candidate's career development focus on developing expertise in PET imaging will be facilitated by the Research Plan. This pilot project involves obtaining florbetapir (18F) PET data in older adults with depression with the overarching aim of investigating the role of amyloid deposition on cognition and antidepressant outcomes. This project is linked to the Candidate's current R01, a study examining structural and functional MRI biomarkers influencing antidepressant treatment outcomes. By acquiring data on amyloid binding in 33 cognitively intact but depressed individuals, this project will test the hypotheses that increased amyloid binding is associated with poorer cognitive performance and poorer response to 8 weeks of blinded escitalopram. By integrating the PET data with MRI data, we will also examine whether this effect is related to early amyloid deposition in default mode network regions, and whether amyloid deposition is associated with altered network functional connectivity. Overall, this award will provide crucial support for the Candidate to expand his research expertise and mentoring programs. It will also provide novel information on the effects of Alzheimer neuropathology on late-life depression outcomes that will guide future proposals.

这是针对患者研究的K24中级护理研究者奖的新提交。 该提案的总体目标是允许候选人沃伦·泰勒（Warren D. Taylor），至1） 发展宠物成像和2）获得指导初级的技能和经验 研究人员。这将扩大他过去检查临床结果的生物标志物的工作 在指导新研究者的同时，抑郁症进入细胞和分子测量 生物标志物方法研究了重要的临床结果。为了实现这些目标， 职业发展计划提供了宠物成像方法的培训， 分析PET成像数据和多模式成像分析的方法，将PET和PET结合在一起 MRI数据。他的指导能力将通过作为当地的教师和 国家指导研讨会，正规培训以及制定研究培训计划的工作。 支持这些目标，指导计划着重于以患者为导向的初级调查员 对抑郁症感兴趣的研究。利用多个范德比尔特资源来识别和 支持这些受训者，候选人将提供研究方法的动手培训 以准备出版的科学报告和入门级赠款的目标的目标 申请。范德比尔特（Vanderbilt）的大量机构资源将增加提供的经验 由候选人。最后，候选人的职业发展专注于发展专业知识 研究计划将促进宠物成像。这个试点项目涉及获得 Florbetapir（18F）抑郁症老年人的宠物数据，其总体目的 研究淀粉样蛋白沉积在认知和抗抑郁剂结果上的作用。这 项目与候选人的当前R01有关，该研究研究了结构和功能性MRI 影响抗抑郁治疗结果的生物标志物。通过获取淀粉样蛋白的数据 在33个认知完整但沮丧的个体中具有约束力，该项目将检验假设 淀粉样蛋白结合的增加与认知性能较差和较差有关 对8周盲目的依他张兰的反应。通过将PET数据与MRI数据集成在一起，我们 还将检查这种效果是否与默认模式下的早期淀粉样蛋白沉积有关 网络区域，以及淀粉样蛋白沉积是否与变化的网络功能相关 连接性。总体而言，该奖项将为候选人扩大他的关键支持 研究专业知识和指导计划。它还将提供有关效果的新颖信息 关于后期抑郁症结果的阿尔茨海默氏症神经病理学将指导未来的建议。