Functional Mapping of the afferent and Efferent Projections of the Superior Cervical Ganglion Interactome

颈上神经节相互作用组传入和传出投影的功能图

基本信息

批准号：
9531826
负责人：
stephen john lewis
金额：
$ 61.34万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-27 至 2018-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9531826
关键词：
Airway Resistance Anatomy Anti-Inflammatory Agents Anti-inflammatory Apnea Automobile Driving Autonomic ganglion Blood Pressure Brain Breathing Carotid Body Cell Nucleus Cervical Coronary artery Development Devices Diabetes Mellitus Disease Electric Stimulation Environmental air flow Etiology Event Exposure to Fatty acid glycerol esters Female Future Ganglia Gases Health Human Hypertension Hypotension Hypothalamic structure Hypoxia Implant Inflammatory Ipsilateral Knowledge Larynx Left Life Maps Mechanics Mediating Modeling Monitor Motor Nasopharynx Nerve Neurobiology Neurons Obesity Organ Outcome Study Pathway interactions Patients Pattern Peptides Peripheral Pharmaceutical Preparations Physiological Physiological Processes Play Process Rat Strains Rattus Regional Blood Flow Regulation Research Rest Role Route Salivary Glands Sensory Site Sleep Apnea Syndromes Spinal Cord Column Sprague-Dawley Rats Structure Structure of superior cervical ganglion Submandibular gland System Techniques Tongue Vascular resistance Work base cerebral artery cerebral hypoperfusion falls glossopharyngeal hemodynamics implantation individualized medicine male neural circuit neuroregulation novel novel therapeutics paraventricular nucleus prevent response virtual

项目摘要

This project will map the neuroanatomical connections of the superior cervical ganglia (SCG) in both male and female Sprague-Dawley rats, a model of healthy humans, and the neurobiological effects elicited by electrical stimulation of the cervical sympathetic chains that innervate the SCGs. We expect to extend our present work that suggests that the left and right SCG have different physiological functions and that the left and right SCG talk to one another within the brain to co-ordinate breathing and blood pressure. This work is vital because we believe that a loss of activity of SCG input to the brain and key structures within the body is responsible for the expression of numerous inflammatory disorders including sleep apnea and nocturnal hypertension. As such, we are confident that the work performed in this project will form the basis of future development of novel stimulating devices that will be implanted around the post-ganglionic nerves emanating from the left and/or right SCG in order to specifically treat a disease process that is normally suppressed by the SCG projection.

该项目将绘制颈上神经节 (SCG) 的神经解剖学连接图雄性和雌性斯普拉格道利大鼠（健康人类模型）和神经生物学电刺激颈交感神经链所引起的效应 SCG。我们希望扩展我们目前的工作，表明左右 SCG 有不同的生理功能以及左右 SCG 在大脑内相互交流协调呼吸和血压。这项工作至关重要，因为我们相信，失去 SCG 输入到大脑和体内关键结构的活动负责多种炎症性疾病的表达，包括睡眠呼吸暂停和夜间高血压。作为因此，我们相信该项目中所做的工作将成为未来的基础开发将植入节后神经周围的新型刺激装置源自左侧和/或右侧 SCG，以专门治疗以下疾病过程：通常受到 SCG 投影的抑制。