Metalloenzyme Mimics with Unsupported Metal Nanoparticle Catalysts

无载体金属纳米颗粒催化剂的金属酶模拟物

基本信息

批准号：
9262234
负责人：
Young Shon
金额：
$ 11.06万
依托单位：
CALIFORNIA STATE UNIVERSITY LONG BEACH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9262234
关键词：
Academic support Adsorption Affect Alkenes Alkynes Amino Acids Area Attention Basic Science Behavior Binding Biochemical Biological Biological Models Biological Phenomena Biotechnology Caliber Catalysis Characteristics Chemicals Chemistry Complex Constitutional Data Data Analyses Data Set Development Diffusion Dimensions Education Enrollment Environment Enzymes Evaluation Exhibits Familiarity Female Funding Goals Hispanic-serving Institution Hydrocarbons Hydrogenation Hydrophobicity Immobilization Information Dissemination Interdisciplinary Study Investigation Isomerism Knowledge Laboratory Research Learning Ligands Literature Medical Research Metals Methods Minority Access Minority Participation Modeling Molecular Conformation Nanostructures Nanotechnology Optics Palladium Participant Pattern Performance Property Publishing Reaction Recruitment Activity Reporting Research Research Activity Research Infrastructure Research Methodology Research Personnel Role Scientist Shapes Side Solubility Solvents Structure Structure-Activity Relationship Students Surface System Tail Techniques Technology Translational Research Travel Underrepresented Groups United States National Institutes of Health Water Work alkyl group base bridge to the baccalaureate career catalyst density design enzyme model experience experimental study functional group fundamental research globular protein interest learning outcome meetings metallicity metalloenzyme minority student minority undergraduate nanomaterials nanoparticle nanoparticulate nanostructured novel organic base particle programs public health relevance skills undergraduate research undergraduate student

项目摘要

DESCRIPTION (provided by applicant): The homogeneous catalysis based on the principle of diffusion of ligand-capped metal nanoparticles has recently drawn more interest as regards to its potential as enzyme mimics, which are one of the highest priority areas in the field of biotechnology and medical research. In particular, the ability of simple model nanostructured materials in enhancing or resisting the adsorption of particular substrates similar to that of enzymes is in needs of active investigation. Our research group has recently developed a new catalytic system that exhibits excellent activity and selectivity for the isomerization and/or hydrogenation of alkenes and alkynes. Considering their size (6-8 nm in overall particle diameter), spherical shape, and versatile ligand characteristics, the availability of these well-designed organic ligand-capped nanoparticles with active catalytic metal core will especially benefit the advancement in nanoparticle-based metalloenzyme mimics. For example, by introducing different hydrophobic functional groups in the "tail" of hydrocarbon chains of organic ligands, we can adjust steric and/or non-covalent interactions in the near-surface environment in a manner analogous to changing amino acid residues (side groups) in an enzyme binding pocket. This approach will allow the investigation of the ability of surface immobilized ligands on precisely tuning catalytic selectivity through these molecular interactions. The proposed four-year SCORE SC3 research program will focus on understanding how near-surface steric controls, non-covalent interactions, and chiral interactions determine the catalytic properties of the modified nanoparticles towards the model organic reactions relevant to the biologically important transformations (olefin reduction and isomerization). Requested funding provides summer and academic support for the PI, support for 1 post-baccalaureate fellow or technician/year, chemicals, supplies, lab consumables for research activity, and travel expenses for dissemination. The work involves four major tasks: 1) Metalloenzyme mimics with near-surface steric controls for chemo selective and regioselective reactions. 2) Metalloenzyme mimics with non-covalent interactions for chemo selective and regioselective reactions. 3) Metalloenzyme mimics with chiral interactions for stereo selective reactions. 4) Metalloenzyme mimics with controlled surface ligand polarity for biologically important reactions in water. This research plan will allow the PI to develop the basic and translational research skills to become an independent expert in nanomaterials structure controls, materials characterizations, and metalloenzyme mimics for biologically important transformations. Simultaneously, this program will provide graduate (M.S.-level, 2 students/year) and undergraduate students (4 students/year) with unique and exciting research opportunities in nanotechnology. Through enrollment in existing research-based classes, students will be offered the opportunity to be participants in an interdisciplinary research program that will collaborate on all aspects of this project - from inception, starting with basic nanoparticulate material synthesis, to completion, with the ultimate evaluation of the catalytic performance of these new metalloenzyme mimics. They will also develop the intellectual capacity to critically analyze existing information as well as develop proficiency in the analysis, interpretation and presentation of complex data sets. PI will actively recruit females and/or minority students, traditionally underrepresented groups in chemistry, to enhance the balanced advancement of research and education (CSULB is designated as a Hispanic Serving Institution). PI has a good track record of participating minority undergraduate research programs such as BUILD (Building Infrastructure Leading to Diversity funed by NIH), MARC (Minority Access to Research Careers funded by NIH), RISE (Research Initiative for Scientific Enhancement funded by NIH), BRIDGES (Bridges to the Baccalaureate funded by NIH), in addition to LSAMP (Louis Stokes Alliance for Minority Participation program funded by NSF) that are currently available in CSULB.

描述（由申请人提供）：基于配体金属金属纳米颗粒扩散原理的均质催化，它引起了对总计酶的更加兴趣，这是生物技术和医学研究领域中最高的优先领域之一。特别是，简单的模型材料可以增强或抵抗类似于酶的特定ES的吸附，这是活性发明的需求。具有催化金属芯的精心设计的有机配体限制的纳米颗粒的可用性将特别受益于在有机配体的碳氢化合物链中引入不同的疏水型组的进步，我们可以调整空间和/或非共价相互作用氨基酸残基（侧基组）的近地表环境在酶结合袋中。精确调整催化选择性通过分子相互作用，这些它们的四年得分得分将重点介绍近距性的控制，非共价相互作用和分解与模型有机反应相关的催化性能生物学上重要的（减少烯烃和同构），pi，后龙或技术人员/年份，化学物质，供应，实验室消耗品，用于研究活动。化学反应的对照。研究计划将开发基本和技能，以成为纳米植物的独立专家，材料特征和金属酶模仿生物学上重要的转变（M.S.级别，2个学生/年）和地下学生（4个学生/年））在基于研究的班级中，纳米技术的独特和退出的研究都将成为ANN跨学科计划的机会。压缩，最终评估核糖因学还将开发智力上的信息，并开发出复杂数据集的学报，解释和呈现。招募女性和/或少数族裔学生，传统上代表性不足的化学成果（CSULB被指定为西班牙裔服务式工具）。由NIH资助的桥梁（由NIH资助的桥梁）资助，除了LSAMP（LSAMP（由NSF资助的Louis Stokes Alliance for Mional参与计划）外，目前还可以在Csulb中提供。