Differences in Pain Between Alzheimer's Disease and Vascular Dementia in Older Females

老年女性阿尔茨海默氏病和血管性痴呆的疼痛差异

基本信息

批准号：
9353271
负责人：
RONALD L COWAN
金额：
$ 6.43万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9353271
关键词：
Acute Pain Address Affect Affective Age Alzheimer&apos s Disease Analgesics Awareness Behavioral Biological Blood Vessels Clinical Cognitive Comorbidity Cutaneous Data Data Set Dementia Detection Development Diagnosis Dimensions Disease Elderly Female Foundations Future Gender Goals Health Care Costs Health Personnel High temperature of physical object Impairment Individual Injury Knowledge Lateral Lesion Literature Longevity Malignant Neoplasms Measures Medial Mediating Mission Observational Study Pain Pain Measurement Pain Threshold Pain intensity Pain management Pathology Pathway interactions Pilot Projects Practice Management Psychophysics Public Health Publishing Quality of life Reporting Research Risk Sampling Sensory Sensory Thresholds Stimulus Symptoms System Techniques Temperature United States National Institutes of Health Vascular Dementia Woman associated symptom central pain chronic pain clinical practice cohort disorder control end of life enhancing factor experience gender difference high risk improved male men multidisciplinary nociceptive response novel psychosocial public health relevance relating to nervous system response white matter

项目摘要

DESCRIPTION (provided by applicant): Poorly treated pain in older adults with dementia is a critical public health problem. When compared to people without dementia, people with dementia receive less pain medication in the presence of similar pain-related conditions. Gender associated differences in the experience of pain are reported in the literature with women generally experiencing more pain and reporting increased sensitivity. Poorly treated pain leads to many associated symptoms, negatively impacts quality of life, and increases healthcare costs. Exploring the biological reasons for alterations in pain processing is essential to increasing our understanding about pain in older adults with Alzheimer's disease (AD) and Vascular dementia (VaD). The paucity of evidence to support best practice pain management in older adults with different types of dementia places these individuals at risk for poor pain management practices. The goals of this project are to determine AD- or VaD-associated psychophysical and psychosocial differences in the processing of pain in older females. Our pilot data in a sample of 12 male and 12 female (age-matched) cognitively normal older adults (ages 65-81) suggests that in response to thermal pain, females reported decreased sensory thresholds for pain and reduced pain associated unpleasantness. A second pilot sample of observational pain in people with AD and VaD indicated that people with VaD may have more behavioral indicators of pain. Using psychophysics (to measure sensory threshold and affective unpleasantness) we will examine dementia and gender-associated differences in thermal pain processing in a broad range of older adults with AD or VaD (age 66-95). Our overall hypothesis is that specific alterations in experimental thermal pain responses, which reflect differences in central pain processing and are of relevance to clinical pain responsiveness, are associated with dementia subtypes (AD, VaD), and amount of white matter vascular lesion burden. These changes may place women with certain dementia subtypes at increased risk for non-detection of pain following injury, under treatment of pain, development of chronic pain, and poor quality of life at end-of-life. Results from this study will contribute to development of improved targeted pain assessment techniques and pain management approaches.

描述（由申请人提供）：与没有痴呆症的人相比，患有痴呆症的老年人的疼痛是一个关键的公共卫生问题。疼痛的经历会增加疼痛和报告的敏感性。 VAD）。 12个男性和12位女性（年龄匹配）认知的样本（65-81岁）表明，在AD VAD患者中，第二次观察性疼痛的试验样本表明，患有VAD的人可能会有更多心理物理学的指标（为了衡量感官折射和情感的不适应），我们将在广泛的AD或VAD的老年人中检查痴呆症和性别相关的ES（年龄66-95岁）。反映出这些变化的情况可能与Witens相关，与痴呆症亚型（AD，VAD）以及白质血管病变负担的数量有关。生命终止的疼痛寿命。疼痛评估技术和疼痛管理方法。