Chronic orofacial pain: genetics, cognitive-emotional factors, and endogenous modulatory systems
慢性口面部疼痛:遗传、认知情绪因素和内源性调节系统
基本信息
- 批准号:9265070
- 负责人:
- 金额:$ 54.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-04-20 至 2020-03-31
- 项目状态:已结题
- 来源:
- 关键词:Absence of pain sensationAddressAdherenceAffectAffectiveAmericanAmygdaloid structureAnalgesicsAreaBehavioralBehavioral ModelBiologicalBrainBrain regionCandidate Disease GeneChronicChronic DiseaseClinicalCognitiveComplexDataDevelopmentEconomic BurdenEconomicsExpectancyExposure toFrightFunctional Magnetic Resonance ImagingFunctional disorderGenesGeneticGenetic MarkersGenetic VariationGenotypeHumanImageIndividualKnowledgeLinkMediatingModelingMutationNTRK2 geneNaloxoneNarcotic AntagonistsNegative ValenceNeuronsNeurotic DisordersNeuroticsOpioid ReceptorOrofacial PainOutcomePainPain managementPathway interactionsPatientsPerceptionPersonalityPharmacogenomicsPharmacological TreatmentPharmacologyPhenotypePlacebosPlayPopulationPositive ValencePositron-Emission TomographyPredispositionPrefrontal CortexProcessPublic HealthRecording of previous eventsReportingRewardsRisk FactorsRoleSecondary toSeveritiesSeverity of illnessShapesSystemTemporomandibular Joint DisordersTestingTherapeuticTherapeutic InterventionTimeTranslatingUnited StatesVariantVentral Striatumbasebehavioral studychronic painclinical phenotypecopingcostemotional factorendogenous opioidsendophenotypeexperiencegenetic predictorsgenetic variantimaging approachmu opioid receptorsnegative affectneurobiological mechanismneurotransmissionnew therapeutic targetnovelnovel strategiesopioid usepsychologicpublic health relevanceresponsesensorsocialsuccesstherapy outcometraittreatment planningtreatment responders
项目摘要
DESCRIPTION (provided by applicant): Chronic pain affects a large number of Americans, costing an estimated $600 billion annually. In particular, temporomandibular joint disorder (TMD), a complex chronic pain condition influenced by biological, psychological, environmental and social factors affects about 6% of the population. Recent studies suggest that genetics plays an important role in pain sensitivity, modulation and susceptibility to the development of chronic pain and TMD. Individual chronic pain experience is highly variable; some people are mildly affected, while others suffer debilitating dysfunction. Individuals also vary substantially n their responses to therapeutic interventions; for some, pharmacological treatments are highly efficacious while in others only modest reductions in pain occur. Up to 50% of the variability in clinical pain outcomes has been shown to be secondary to expectancy-induced analgesia, defined as the reduction in pain in an individual that results from his or her perception of the therapeutic intervention. In other words, patients' expectancies can modulate the individual pain experience, processing and response to pain treatments. Therefore, better understanding of the genetic effects on expectancy-induced analgesia and the variability in proneness to activate endogenous inhibitory systems is critical to optimize pain treatments. We developed a novel comprehensive genetic, behavioral and imaging approach to study the role of genetic variations on behavioral, psychological and neuronal mechanisms of expectancy-induced analgesia in patients with TMD. We address the following specific aims: 1. Test the hypothesis that variants in candidate genes are associated with expectancy-induced analgesia predicting chronic orofacial pain endophenotypes; 2. Test the hypothesis that individual psychological traits are unique modulators of the complex genetic moderation of expectancy-induced analgesia, regardless of the severity of the disease; and 3. Test the hypothesis that variations in the specific (identified) genes predict expectancy-induced analgesia and related neuronal changes in the prefrontal and limbic areas. The identified genotypes will serve as important markers to predict subjective (e.g. pain reports) and objective (e.g. neuronal) responses to expectancy-induced analgesia while controlling for modulatory effects of distinct personalities. We anticipate: a) to provide a new framework to study the pharmacogenomics of chronic orofacial pain, b) to identify genetic markers and mechanisms that can be used to develop new therapeutic targets and strategies and ultimately, c) to determine which patients are most likely to respond to specific treatments.
描述(由申请人提供):慢性疼痛会影响大量美国人,估计每年6000亿美元,Mandibular关节疾病(TMD),这是一种复杂的慢性疼痛状况,这是生物学,心理,环境因素的影响人口最近表明,遗传学在慢性疼痛和TMD的疼痛敏感性中的作用高度可变。发生疼痛。对疼痛信任的处理和反应。预期诱导的TMD患者的镇痛机制。特定(确定的)BIC区域中的论文。一个新的框架,用于研究慢性口面疼痛D策略的药物基因组学,最终,c)确定哪些患者最有可能对特定的信任做出反应。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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Luana Colloca其他文献
Luana Colloca的其他文献
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{{ truncateString('Luana Colloca', 18)}}的其他基金
Secondary Analysis and Integration of Existing Data Related to Chronic Orofacial Pain and Placebo Effects - Administrative Supplement
与慢性口面部疼痛和安慰剂效应相关的现有数据的二次分析和整合 - 行政补充
- 批准号:
10741330 - 财政年份:2023
- 资助金额:
$ 54.66万 - 项目类别:
Secondary Analysis and Integration of Existing Data Related to Chronic Orofacial Pain and Placebo Effects
与慢性口面部疼痛和安慰剂效应相关的现有数据的二次分析和整合
- 批准号:
10597861 - 财政年份:2022
- 资助金额:
$ 54.66万 - 项目类别:
Neural Mechanisms of Immersive Virtual Reality in Chronic Pain
沉浸式虚拟现实治疗慢性疼痛的神经机制
- 批准号:
10617854 - 财政年份:2021
- 资助金额:
$ 54.66万 - 项目类别:
Neural Mechanisms of Immersive Virtual Reality in Chronic Pain
沉浸式虚拟现实治疗慢性疼痛的神经机制
- 批准号:
10314729 - 财政年份:2021
- 资助金额:
$ 54.66万 - 项目类别:
Neural Mechanisms of Immersive Virtual Reality in Chronic Pain
沉浸式虚拟现实治疗慢性疼痛的神经机制
- 批准号:
10455010 - 财政年份:2021
- 资助金额:
$ 54.66万 - 项目类别:
Neural correlates of hypoalgesia driven by observation
观察驱动的痛觉减退的神经相关性
- 批准号:
10452769 - 财政年份:2019
- 资助金额:
$ 54.66万 - 项目类别:
Neural correlates of hypoalgesia driven by observation
观察驱动的痛觉减退的神经相关性
- 批准号:
10212245 - 财政年份:2019
- 资助金额:
$ 54.66万 - 项目类别:
Neural correlates of hypoalgesia driven by observation
观察驱动的痛觉减退的神经相关性
- 批准号:
10673015 - 财政年份:2019
- 资助金额:
$ 54.66万 - 项目类别:
Chronic orofacial pain: genetics, cognitive-emotional factors, and endogenous modulatory systems
慢性口面部疼痛:遗传、认知情绪因素和内源性调节系统
- 批准号:
9098079 - 财政年份:2016
- 资助金额:
$ 54.66万 - 项目类别:
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