2017 Muscle: Excitation-Contraction Coupling Gordon Research Conference and Gordon Research Seminar

2017肌肉：兴奋-收缩耦合戈登研究会议暨戈登研究研讨会

• 批准号: 9331041
• 负责人: Hector H Valdivia
• 金额: $ 2.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9331041
• 关键词: Addendum; Aging; Area; Atrophic; Back; Basic Science; British Columbia; Calcium Signaling; Career Mobility; Clinical; Clinical Research; Clinical Trials; Communication; Communities; Coupling; Crystallization; Defect; Development; Discipline; Disease; Elements; Environment; Functional disorder; Gender; Geographic Locations; Goals; Government; Growth; Health; Heart Diseases; Human; Individual; Industrialization; Inherited; Institutes; International; Knowledge; Lead; Leadership; Maine; Medical; Metabolic Diseases; Metabolism; Michigan; Molecular; Muscle; Muscle Fatigue; Mutation; Myocardium; Myopathy; Neuromuscular Diseases; Neurosciences; Outcome; Participant; Patients; Performance; Postdoctoral Fellow; Process; Quality of life; Race; Regulation; Research; Research Personnel; Resolution; Roentgen Rays; Ryanodine Receptor Calcium Release Channel; Scientist; Skeletal Muscle; Structure; Students; Switzerland; Time; Translational Research; Triad Acrylic Resin; Universities; Work; career; combat; effective therapy; experience; graduate student; improved; innovation; insight; meetings; new therapeutic target; news; novel strategies; novel therapeutics; posters; programs; public health relevance; sarcopenia; skeletal; success; symposium

ABSTRACT This is a proposal for partial support of the only major national and/or international meeting dedicated to excitation/contraction coupling and how defects in this critical process underlie muscle disease. The Muscle: Excitation-Contraction Coupling (ECC) Gordon Research Conference (GRC) will meet from June 4 – June 9, 2017 at Les Diablerets Conference Center in Les Diablerets, Switzerland. The GRC program was developed by an Executive Organizing Committee consisting of leaders in ECC research including Drs. Héctor H. Valdivia (University of Michigan), Isabelle Marty (Grenoble Institute of Neurosciences), and Filip Van Petegem (University of British Columbia). The two overarching objectives of the 2017 Muscle: Excitation-Contraction Coupling GRC are: Objective 1: To discuss and critically evaluate new breakthroughs regarding the molecular mechanisms that control ECC and how this process is altered in muscle fatigue, atrophy, sarcopenia, metabolic disease, and genetically-inherited forms of skeletal and cardiac muscle disease. Objective 2: To promote visibility and leadership of junior investigators in the field by providing a platform for students, postdoctoral fellows, and new independent investigators to present their work, as well as to interact and network with established senior investigators. The 2017 GRC conference will consist of ~30 speakers, ~18 Discussion Leaders, and ~13 poster presentations. Scientific sessions will focus on structural studies of the ECC apparatus, new insights into the molecular mechanisms and regulation of ECC, identification of new therapeutic targets, and the development of innovative treatments for muscle fatigue, sarcopenia, and skeletal and cardiac muscle disorders that adversely impact millions of individuals in the US. For the second time for this GRC, the meeting will be preceded by a two-day Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows. In addition, for each session during the GRC a young investigator will be paired with a senior investigator to serve as Co-Discussion Leaders. Innovative “Poster Flash Sessions” and “This Just In” speaker slots will be used to highlight late-breaking news. These innovative program elements will also maximize poster session visibility, as well as to enhance the integration and exposure of promising young investigators in the field during the GRC. We expect that this conference will attract 150-200 basic and clinical scientists across all career stages, genders, races, heritages, research disciplines, professional affiliations (academic, industrial, government), and geographical locations. Our overall aim is to promote: 1) open dialogue and communication, 2) exposure and career advancement of promising young investigators in the field, 3) fundamental understanding in the mechanisms of ECC and how defects in this process lead to compromised skeletal and cardiac muscle performance, and 4) the development of novel and effective therapies to combat skeletal and cardiac muscle disorders.

抽象的 这是对唯一致力于的全国和/或国际会议的部分支持的建议 兴奋/收缩耦合以及这种关键过程中的缺陷是肌肉疾病的基础。肌肉： 激发诱导耦合（ECC）戈登研究会议（GRC）将于6月4日至6月9日开会 2017年在瑞士Les Diablerets的Les Diablerets会议中心。 GRC计划已开发 由一个由ECC研究领导者组成的执行组织委员会，包括DRS。 HéctorH. Valdivia （密歇根大学），伊莎贝尔·马蒂（Isabelle Marty）（格勒诺布尔神经科学研究所）和菲利普·范·皮格格（Filip Van Petegem） （不列颠哥伦比亚大学）。 2017年肌肉的两个总体物体：激发控制 耦合GRC是：目标1：讨论并批判性地评估有关有关的新突破 控制ECC的分子机制以及该过程如何改变肌肉疲劳，萎缩， 肌肉减少症，代谢性疾病以及骨骼和心脏肌肉疾病的遗传亲属形式。 目标2：通过提供一个平台来促进该领域的初级调查员的知名度和领导 学生，博士后研究员和新的独立调查员介绍他们的作品以及互动 并与已建立的高级调查员建立联系。 2017年GRC会议将包括约30个发言人，〜18 讨论领导者和约13个海报演示。科学会议将重点介绍 ECC设备，对ECC分子机制和调节的新见解，新的鉴定 治疗靶标，以及用于肌肉疲劳，肌肉减少症和骨骼的创新治疗 和心脏肌肉障碍会对美国数百万人产生不利影响。第二次 在此GRC之前，会议将在为期两天的Gordon研究研讨会（GRS）之前为研究生 和博士后研究员。此外，对于GRC期间的每个会话，年轻的调查员将与 高级调查员担任共同讨论领导人。创新的“海报闪光灯会议”和“这只是在此中” 扬声器插槽将用于突出发生后期新闻。这些创新的计划元素也将 最大化海报会话可见性，并增强承诺年轻人的融合和暴露 GRC期间该领域的调查人员。我们希望这次会议将吸引150-200的基本和临床 各个职业阶段的科学家，性别，种族，遗产，研究学科，专业分支机构 （学术，工业，政府）和地理位置。我们的总体目的是促进：1）开放 对话与沟通，2）在诺言中的暴露和职业发展年轻调查员 领域，3）ECC机制的基本理解以及此过程中的缺陷如何导致 骨骼和心肌表现受损，以及4）新颖有效的发展 对抗骨骼和心肌疾病的疗法。