National Biomedical Information Services

国家生物医学信息服务

基本信息

批准号：
9556042
负责人：
Betsy Humphreys
金额：
$ 30981.11万
依托单位：
NATIONAL LIBRARY OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9556042
关键词：
Address Adverse event African American Amendment Antimicrobial Resistance Archives Area Automated Indexing Awareness Bibliographic Databases Bioinformatics Biological Biomedical Computing Biotechnology Blood Breast Feeding Cells Centers for Disease Control and Prevention (U.S.)Characteristics Clinical Clinical Practice Guideline Clinical Research Clinical Trials Code Collaborations Collection Common Data Element Communication Communities Computational Biology Computer software Congresses Controlled Vocabulary Country Data Data Science Data Set Databases Development Diagnostics Research Disasters Drug Labeling Education Electronic Health Record Emergency Situation Environmental Health Family Fostering Funding Funding Agency Genbank General Population Generations Genes Genetic Genetic screening method Genome Genomics Genotype Goals Hazardous Chemicals Hazardous Substances Health Health Professional Health Sciences Health Services Research Health Technology Health system Healthcare Healthy People 2020 Herbal supplement High-Throughput Nucleotide Sequencing Hispanic Americans Human Genome ICD-10-CM Image Imagery Improve Access Informatics Information Centers Information Dissemination Information Management Information Resources Information Services Information Systems International International Classification of Disease Codes Intervention Intramural Research Program Joints Journals Language Libraries Licensing Link Literature Logical Observation Identifiers Names and Codes MEDLINE Magic Malaria Maps Measures Medical Medical Informatics Medicine MedlinePlus Molecular Biology Mothers Names Native Americans Nuclear Nursing infant Opiate Addiction Package Insert Patient Education Patients Pharmaceutical Preparations Phenotype Physicians Play Poison Control Centers Policies Population Privatization PubChem PubMed Public Health Publications Published Comment Publishing Radiology Specialty Readiness Records Registries Regulation Reproducibility Research Research Infrastructure Research Personnel Research Project Grants Research Support Resolution Resources Retrieval Role SNOMED Clinical Terms Software Tools Solid Speed Standardization Structure Subject Headings System Systematized Nomenclature of Medicine Technology Terminology Testing Text Thoracic Radiography Time Toxicology Toxicology Data Network Toxics Release Inventory Tuberculosis Underserved Population Unified Medical Language System United States National Institutes of Health United States National Library of Medicine United States Public Health Service Update Vocabulary authority base bioimaging biomedical informatics biomedical information system clinical diagnostics combat comparative effectiveness data sharing database of Genotypes and Phenotypes dosage drug market drug standard emergency service responder environmental toxicology foodborne illness genome wide association study health data health disparity health information technology health literacy implantable device improved indexing instrument interoperability journal article knowledge base language processing liver injury metathesaurus online resource outreach outreach program pathogen personalized health care population health programs public health emergency quality assurance repository research and development research study response scientific computing support tools systems research tool web portal web site

Address Adverse event African American Amendment Antimicrobial Resistance Archives Area Automated Indexing Awareness Bibliographic Databases Bioinformatics Biological Biomedical Computing Biotechnology Blood Breast Feeding Cells Centers for Disease Control and Prevention (U.S.)Characteristics Clinical Clinical Practice Guideline Clinical Research Clinical Trials Code Collaborations Collection Common Data Element Communication Communities Computational Biology Computer software Congresses Controlled Vocabulary Country Data Data Science Data Set Databases Development Diagnostics Research Disasters Drug Labeling Education Electronic Health Record Emergency Situation Environmental Health Family Fostering Funding Funding Agency Genbank General Population Generations Genes Genetic Genetic screening method Genome Genomics Genotype Goals Hazardous Chemicals Hazardous Substances Health Health Professional Health Sciences Health Services Research Health Technology Health system Healthcare Healthy People 2020 Herbal supplement High-Throughput Nucleotide Sequencing Hispanic Americans Human Genome ICD-10-CM Image Imagery Improve Access Informatics Information Centers Information Dissemination Information Management Information Resources Information Services Information Systems International International Classification of Disease Codes Intervention Intramural Research Program Joints Journals Language Libraries Licensing Link Literature Logical Observation Identifiers Names and Codes MEDLINE Magic Malaria Maps Measures Medical Medical Informatics Medicine MedlinePlus Molecular Biology Mothers Names Native Americans Nuclear Nursing infant Opiate Addiction Package Insert Patient Education Patients Pharmaceutical Preparations Phenotype Physicians Play Poison Control Centers Policies Population Privatization PubChem PubMed Public Health Publications Published Comment Publishing Radiology Specialty Readiness Records Registries Regulation Reproducibility Research Research Infrastructure Research Personnel Research Project Grants Research Support Resolution Resources Retrieval Role SNOMED Clinical Terms Software Tools Solid Speed Standardization Structure Subject Headings System Systematized Nomenclature of Medicine Technology Terminology Testing Text Thoracic Radiography Time Toxicology Toxicology Data Network Toxics Release Inventory Tuberculosis Underserved Population Unified Medical Language System United States National Institutes of Health United States National Library of Medicine United States Public Health Service Update Vocabulary authority base bioimaging biomedical informatics biomedical information system clinical diagnostics combat comparative effectiveness data sharing database of Genotypes and Phenotypes dosage drug market drug standard emergency service responder environmental toxicology foodborne illness genome wide association study health data health disparity health information technology health literacy implantable device improved indexing instrument interoperability journal article knowledge base language processing liver injury metathesaurus online resource outreach outreach program pathogen personalized health care population health programs public health emergency quality assurance repository research and development research study response scientific computing support tools systems research tool web portal web site

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项目摘要

Delivering Biomedical Information Services In FY17, NLM greatly expanded the quantity and range of high quality information and data available to researchers, health professionals, and the public. Among the NLM's intramural programs that contribute to its national biomedical information services are: PubMed: PubMed, which incorporates MEDLINE, is NLM's premier bibliographic database with over 27 million references to biomedical journal articles. Articles are indexed by experts using the Medical Subject Headings (MeSH) controlled vocabulary, updated annually. In FY17 over 850,000 new indexed citations were added. PubMed Commons, which enables authors to share opinions and other information about scientific publications, potentially helping to improve reproducibility, added comments on nearly 1,400 PubMed records. NLM also expanded use of automated indexing technology to increase efficiency. PubMed Central (PMC): The PMC archive of over 4 million full-text journal articles is central to the effort to make published results of NIH-supported research publicly accessible. As of FY17, PMC also enables public access to published results of research supported by 8 other federal agencies, as well as private and international research funders. MedlinePlus and MedlinePlus en espanol: These consumer health information resources cover over 985 topics, with selected materials in more than 40 languages. In FY17 HealthReach was added to increase coverage of non-English materials. MedlinePlus Connect links electronic health records to patient education information from MedlinePlus by leveraging standardized codes and vocabularies required for meaningful use. Clinical Trials: clinicaltrials.gov covers over 250,000 clinical research studies in 200 countries, with hundreds added weekly. It also contains summaries of trial results, including adverse events. in accordance with the FDA Amendments Act of 2007 (PL 110-85) and the regulations (42 CFR Part 11) implementing PL 110-85. In FY17, about 24,000 new trials were registered. Summary results for nearly 5,500 trials were added, bringing the total to nearly 28,000. NLM staff also assisted NIH in implementing 42 CFR Par 11 and a new policy covering registration and results submission for all NIH-funded trials. Environmental Health and Toxicology: TOXNET is a primary reference for toxicologists, poison control centers, public health officials, physicians and environmental health professionals, and includes databases such as TOXLINE, Toxics Release Inventory, Hazardous Substances Data Bank, ToxMap and Haz-Map. K-12 resources include an environmental health website and the GeneEd resource to support genetics education. Drug Information Resources: These include Drug Information Portal, DailyMed, Pillbox, LiverTox, and LactMed. The portal provides information on drugs from clinical trial to the marketplace. DailyMed provides drug labeling information from package inserts for nearly 90,000 marketed drugs, with improved mobile access; Pillbox enables rapid identification of unknown solid-dosage medications based on physical characteristics and images. Both are linked to NLM's RxNorm standard drug names. LiverTox provides comprehensive clinical, diagnostic and research information and case registry on liver injury due to drugs, herbals and dietary supplements. LactMed is a database of the effects of drugs on breastfeeding mothers and their nursing infants. In FY17 NLM developed a guide to web resources the opioid addiction and treatment. Disaster and Public Health Emergency Preparedness and Response: NLM's Disaster Information Management Research Center (DIMRC) provides access to disaster information, promotes use of libraries in disaster preparedness and response, and supports uninterrupted access to critical health information resources when disasters and public health emergencies occur. DIMRC produces WISER, CHEMM, and REMM, emergency responder tools for hazardous materials and chemical, biological, radiological, and nuclear incidents. Molecular Biology, Bioinformatics, and Human Genome Resources: NCBI resources include more than 40 integrated molecular biology databases and bioinformatics software tools such as GenBank, Entrez, BLAST, RefSeq, dbGAP, Genomes, PubChem, Genetic Testing Registry, and ClinVar. Continuing areas of emphasis include addressing the impact of enormous quantities of data from high throughput sequencing and microarrays; organizing phenotypic and genotypic data from genome-wide association studies; and enhancing interfaces to journal literature retrieval to facilitate search and discovery. In collaboration with CDC, FDA, and USDA, NCBI is using high throughput sequencing to more rapidly and accurately identify pathogens causing food-borne illnesses; similar technology is being applied to develop resources to combat antimicrobial resistance. Outreach Promoting Public Awareness and Access: Consumer health websites and the NIH MedlinePlus Magazine, in English and Spanish, convey the latest useful research findings in lay language. NLM outreach programs, many achieved through the National Network of Libraries of Medicine, enhance awareness of its information services through dozens of library- and community-based projects funded annually, with emphasis on underserved populations. In FY17, the Network started a 3-year outreach effort to support the NIH All of Us Research Program. Health Services Research: NICHSR promotes access to public health and health services research information. ONESearch was introduced in FY17, offering a uniform interface to the databases HSRProj, covering over 33,000 health services research projects-in-progress from over 300 funding sources, and HSRR for research datasets, instruments and software relevant to health services research, and the PHPartners.org and HSRInfo_Central web portals. Structured search queries are developed to aid in searching PubMed for published research on topics such as comparative effectiveness, population health, health disparities, and Healthy People 2020 objectives. Advanced Information Systems and Research Tools: LHNCBC and NCBI continued to conduct research and development in biomedical informatics and computational biology, tested informatics interventions, and developed new scientific computing tools. For example, researchers enhanced tools that support standards-based electronic health records; improved tools to detect tuberculosis in chest x-rays and count malaria parasitic cells in blood smears; improved and extended Open-I for integrated search and discovery of biomedical images and text; and developed automated summarization system for medical articles. Health Data Standards: As the HHS central coordinating body for clinical terminology standards, NLM provides essential tools for meaningful use of electronic health records (EHRs) and health system interoperability. NLM develops, supports, or licenses for free U.S.-wide use the key clinical terminologies (RxNorm, LOINC, SNOMED CT) designated as standards for U.S. health information exchange. The Unified Medical Language System Metathesaurus, with more than 13 million concept names from nearly 200 vocabularies, is a distribution mechanism for standard code sets and vocabularies used in health data systems. In FY17 the AccessGUDID database that links FDA and SNOMED codes was augmented for over 500,000 implantable devices, in support of a 2018 requirement for certified EHRs, and the SNOMED CT to ICD-10-CM map was updated in the I-Magic (Interactive Map-Assisted Generation of ICD Codes) tool that supports interoperability and quality assurance in EHRs. The Value Set Authority Center (VSAC) deepened support of CMS clinical quality measures, and the Common Data Element Repository was augmented with tools and content to facilitate data sharing, aggregation, and

提供生物医学信息服务在2017财年，NLM大大扩大了研究人员，卫生专业人员和公众可用的高质量信息和数据的数量和范围。在NLM为其国家生物医学信息服务做出贡献的NLM内部计划中，有： PubMed：包含MEDLINE的PubMed是NLM的主要书目数据库，对生物医学期刊文章的参考文献超过2700万。文章由专家使用医学主题标题（网格）控制的词汇索引，每年更新。在2017财年，添加了超过850,000个新的索引引用。 PubMed Commons使作者能够分享有关科学出版物的意见和其他信息，并有助于提高可重复性，并在近1,400个PubMed记录上增加了评论。 NLM还扩展了自动索引技术的使用以提高效率。 PubMed Central（PMC）：超过400万本全文期刊文章的PMC档案是为了公开访问NIH支持的研究结果的努力。截至2017财年，PMC还使公众能够获得由其他8个联邦机构以及私人和国际研究资助者支持的已发表研究结果。 Medlineplus和Medlineplus en Espanol：这些消费者健康信息资源涵盖了985多个主题，其中包含40多种语言的选定材料。在2017财年，HealthReach添加了以增加非英国材料的覆盖范围。 MedlinePlus Connect通过利用有意义使用所需的标准化代码和词汇表，将电子健康记录与患者教育信息从MedlinePlus获得。临床试验：ClinicalTrials.gov涵盖200个国家 /地区的25万多个临床研究，每周增加数百个。它还包含试验结果的摘要，包括不良事件。根据2007年的《 FDA修正案法》（PL 110-85）和实施PL 110-85的法规（42 CFR第11部分）。在2017财年，大约有24,000例新试验注册。添加了近5500次试验的摘要结果，使总数达到近28,000。 NLM的工作人员还协助NIH实施了42 CFR 11 par和新的政策，涵盖了所有NIH资助的试验的注册和结果提交。环境健康和毒理学：TOXNET是毒理学家，毒物控制中心，公共卫生官员，医师和环境卫生专业人员的主要参考，包括毒品，毒理学库存库存，有害物质数据库，Toxmap和Haz-Map等数据库。 K-12资源包括一个环境卫生网站和支持遗传学教育的Geneed资源。药物信息资源：其中包括药物信息门户，Dailymed，Pillbox，Livertox和Lactmed。该门户网站提供有关从临床试验到市场的药物的信息。 Dailymed提供了来自包装插入物的药物标签信息，可用于近90,000种销售药物，并改善移动访问； Pillbox可以根据物理特征和图像快速识别未知的固体剂量药物。两者都与NLM的RXNorm标准药物名称有关。 Livertox提供有关药物，草药和饮食补充剂引起的肝损伤的全面临床，诊断和研究信息以及病例注册。乳酸是药物对母乳母亲及其哺乳婴儿的影响的数据库。在2017财年，NLM制定了网络资源指南，阿片类药物成瘾和治疗方法。灾难和公共卫生应急准备和反应：NLM的灾难信息管理研究中心（DIMRC）提供访问灾难信息，促进图书馆在灾难准备和响应中的使用，并在发生灾难和公共卫生紧急情况时支持对关键健康信息资源的不间断访问。 DIMRC生产明智的，Chemm和REMM，即危险材料以及化学，生物学，放射学和核事件的紧急响应器工具。分子生物学，生物信息学和人类基因组资源：NCBI资源包括40多个综合分子生物学数据库和生物信息学软件工具，例如Genbank，Entrez，Blast，Blast，RefSeq，RefSeq，DBGAP，DBGAP，基因组，Pubchem，Pubchem，Pubchem，Genetic Testing Registry和Cinvar。继续强调的领域包括解决高吞吐量测序和微阵列中大量数据的影响；来自全基因组关联研究的组织表型和基因型数据；并增强与期刊文献检索的界面，以促进搜索和发现。 NCBI与CDC，FDA和USDA合作，使用高吞吐量测序，以更快，更准确地识别导致食物传播疾病的病原体。正在应用类似的技术来开发资源来对抗抗菌抗性。推广公众意识和访问的推广：用英语和西班牙语的《消费者健康网站》和《 NIH Medlineplus》杂志传达了外行语言的最新有用的研究结果。 NLM外展计划是通过国家医学图书馆网络实现的，通过每年资助的数十个基于图书馆和社区的项目来提高其信息服务的认识，重点是服务不足的人群。在2017财年，该网络开始了为期3年的宣传工作，以支持NIH所有人的研究计划。卫生服务研究：NICHSR促进获得公共卫生和卫生服务研究信息的访问。 OneSearch于2017财年引入，提供了数据库HSRPROJ的统一界面，涵盖了33,000多个卫生服务研究项目，来自300多个资助来源，以及与Health Services Research相关的研究数据集，工具和软件的HSRR，以及PhPartners.org和phpartners.org和hsrinfo________________central Web central portals。开发结构化的搜索查询是为了帮助搜索PubMed，以进行有关比较有效性，人口健康，健康差异和健康人2020年目标等主题的发表研究。高级信息系统和研究工具：LHNCBC和NCBI继续在生物医学信息学和计算生物学方面进行研究和开发，测试了信息学干预措施，并开发了新的科学计算工具。例如，研究人员增强了支持基于标准的电子健康记录的工具；改进的工具可检测胸部X射线的结核病，并计算血液涂片中的疟疾寄生细胞；改进和扩展的Open-I用于集成搜索和发现生物医学图像和文本；并开发了用于医学文章的自动汇总系统。健康数据标准：作为HHS中央互联体的临床术语标准，NLM为有意义地使用电子健康记录（EHR）和卫生系统互操作性提供了重要的工具。 NLM开发，支持或免费美国范围的许可证使用指定为美国健康信息交换标准的主要临床术语（RXNORM，LOINC，SNOMED CT）。统一的医学语言系统Metathesaurus拥有超过200个词汇的1300万个概念名称，是用于健康数据系统中使用的标准代码集和词汇的分销机制。 In FY17 the AccessGUDID database that links FDA and SNOMED codes was augmented for over 500,000 implantable devices, in support of a 2018 requirement for certified EHRs, and the SNOMED CT to ICD-10-CM map was updated in the I-Magic (Interactive Map-Assisted Generation of ICD Codes) tool that supports interoperability and quality assurance in EHRs.价值设定的权威中心（VSAC）加深了对CMS临床质量指标的支持，并使用工具和内容增强了公共数据元素存储库，以促进数据共享，聚合和