Longitudinal Assessment of Manic Symptoms

躁狂症状的纵向评估

基本信息

批准号：
8441603
负责人：
BORIS BIRMAHER
金额：
$ 126.56万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-16 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8441603
关键词：
17 year old Academic achievement Address Adolescence Age Alcohol or Other Drugs use Amygdaloid structure Area Attention deficit hyperactivity disorder Awareness Behavior Biological Biological Markers Bipolar Disorder Brain Categories Child Childhood Clinical Collection Comorbidity Cyclothymic Disorder DSM-IV Data Deformity Development Diagnosis Diagnostic Diagnostic and Statistical Manual Disease Doctor of Philosophy Emotional Emotions Enrollment Ensure Environment Equipment and supply inventories Evaluation Event Evolution Face Family Family history of Feeling suicidal Functional Magnetic Resonance Imaging Funding Gender Glossary Goals Growth IGFBP2 gene Image Individual Informal Social Control Intervention Kindling (Neurology)Laboratories Lead Learning Life Longitudinal Studies Magnetic Resonance Imaging Manic Maps Measures Memory Mental Health Services Mental disorders Methods Modeling Mood Disorders Moods National Institute of Mental Health Natural History Neurocognitive Ohio Outcome Parents Participant Pediatric Hospitals Performance Pharmaceutical Preparations Phenotype Predictive Value Process Psychiatric Diagnosis Psychopathology Puberty Race Reaction Time Recording of previous events Recruitment Activity Relapse Relative (related person)Request for Applications Research Research Personnel Resistance Risk Risk Factors Risk-Taking Sampling Severities Short-Term Course Site Specific qualifier value Strategic Planning Structure Subgroup Suicide attempt Support System Symptoms System Task Performances Techniques Testing Time Universities Youth aged base childhood bipolar disorder clinical risk cognitive control cognitive function cohort comparison group depressive symptoms effective therapy emerging adult emotion regulation evidence base evidence based guidelines executive function experience follow-up functional outcomes health care service utilization high risk improved innovation instrument meetings neurocognitive test neuroimaging psychosocial public health relevance relating to nervous system screening sex stressor success young adult

项目摘要

DESCRIPTION (provided by applicant): This competing continuation application requests funds to continue the Longitudinal Assessment of Manic Symptoms (LAMS) study at 4-sites. Over the past 3.5 years, using a valid and reliable screening instrument, children ages 6-12 years were identified with elevated symptoms of mania (ESM) at the time of their first clinical presentation. Approximately 621 youth were identified as having ESM. In addtion, 86 age/race/sex matched comparison children without ESM at first clinical presentation were enrolled. During the LAMS study, these participants were evaluated at baseline and every 6 months thereafter. At each assessment point, youths were evaluated regarding their psychiatric diagnoses, psychiatric symptomatology, mental health service utilization, and psychosocial functioning. As part of this competing continuation application (LAMS2), the investigators propose to continue these 6-month evaluations. In addition, LAMS2 will include both neurocognitive testing as well as neuroimaging techniques in order to identify possible biomarkers that reflect or are related to underlying biological mechanisms that predisopose individuals to the development of bipolar disorders. In acordance with the NIMH's Strategic Plan, LAMS2 would focus on examining and documenting trajectories of youths with ESM and related psychiatric disorders in order to better identify crucial timepoints for intervention. More specifically, the goals of LAMS2 include: 1) examining the stability of ESM over time in relation to changes in mood symptoms and DSM-IV-TR criteria for mood disorders; 2) examining the positive predictive value of ESM alone and in combination with other potential risk factors in order to better identify youth who will eventually develop bipolar disorders (BPD) as they progress into and through adolescence; 3) developing evidence-based, atheoretical, diagnostic criteria for a pediatric phenotype for bipolar spectrum disorders; 4) identifying risk factors associated with poor functional outcomes for youth with ESM; 5) examining the relationships between mood episodes and clinical outcomes over time; 6) evaluating neurocognitive performance, together with functional abnormalities in selected neural systems and their relationship to ESM and the development of BPD during youth and early adulthood. The current participants will begin the competitive renewal period ranging in age from 8-17 years. At the end of LAMS2, June 2015, the cohort will range in years from 13-22 years. For this reason, LAMS 2 will provide an opportunity for the collection of innovative and clinically important data during a period of time in which when study participants will have entered an age of high risk for the development of a bipolar spectrum disorder.

描述（由申请人提供）：本竞争性延续申请要求提供资金以继续在 4 个地点进行躁狂症状纵向评估 (LAMS) 研究。在过去的 3.5 年里，使用有效且可靠的筛查工具，6-12 岁的儿童在首次临床表现时就被诊断出患有躁狂症状 (ESM) 升高。大约 621 名青少年被确定患有 ESM。此外，还纳入了 86 名首次临床表现时未出现 ESM 的年龄/种族/性别匹配的对照儿童。在 LAMS 研究期间，这些参与者在基线时以及此后每 6 个月接受一次评估。在每个评估点，对青少年的精神病诊断、精神病症状、心理健康服务利用和心理社会功能进行评估。作为该竞争性延续申请 (LAMS2) 的一部分，研究人员建议继续进行为期 6 个月的评估。此外，LAMS2 将包括神经认知测试和神经影像技术，以便识别可能的生物标志物，这些生物标志物反映或与使个体容易患双相情感障碍的潜在生物机制相关。根据 NIMH 的战略计划，LAMS2 将重点检查和记录患有 ESM 和相关精神疾病的青少年的轨迹，以便更好地确定干预的关键时间点。更具体地说，LAMS2 的目标包括： 1) 检查 ESM 随着时间的推移相对于情绪症状变化和情绪障碍 DSM-IV-TR 标准的稳定性； 2) 单独检查 ESM 以及与其他潜在危险因素相结合的阳性预测价值，以便更好地识别在进入青春期并度过青春期时最终会患上双相情感障碍 (BPD) 的青少年； 3) 制定双相谱系障碍儿科表型的基于证据的理论诊断标准； 4) 确定与 ESM 青少年功能不良相关的风险因素； 5）随着时间的推移，检查情绪发作与临床结果之间的关系； 6) 评估神经认知表现，以及选定神经系统的功能异常及其与 ESM 的关系以及青少年和成年早期 BPD 的发展。目前的参赛者将开始竞争性更新期，年龄范围为8-17岁。到 2015 年 6 月 LAMS2 结束时，队列的年龄范围为 13 至 22 岁。因此，LAMS 2 将提供一个机会，在研究参与者进入双相谱系障碍高风险年龄的一段时间内收集创新和临床重要数据。