Biorepository Core

生物样本库核心

• 批准号: 8796198
• 负责人: Wendy Anne Wells
• 金额: $ 42.2万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8796198
• 关键词: Aliquot; American; Biocompatible Materials; Biological; Blood; Caring; Centers of Research Excellence; Clinical Laboratory Information Systems; Code; Collaborations; Collection; Complex; Consultations; Databases; Disease; Ensure; Epidemiologic Studies; Epidemiology; Feces; Foundations; Fresh Tissue; Goals; Housing; Human; Human Milk; Human Resources; Laboratories; Medical; Molecular; Molecular Epidemiology; Nucleic Acids; Online Systems; Pathologist; Preparation; Process; Records; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Retrieval; Sampling; Services; Site; Specimen; Structure of nail of toe; Training and Education; Translational Research; Triage; Urine; base; biobank; college; programs

Biospecimens are the basis ofthe molecular characterization of both a disease and its host, and are crucial for modern molecular epidemiologic study. Our goals are to support the proposed projects as part of the Center of Molecular Epidemiology and build a sustainable biorepository that is state-of-the-art and internationally competitive. This will entail creating an infrastructure that provides optimal management and oversight of human biospecimens on a large, efficient scale. The state-of-the-art biorepository proposed in this Core will be housed in a CLIA-certified, College of American Pathologists (CAP)-accredited laboratory that will be renovated as part of this COBRE. The Core also will develop a state-of-the-art Biospecimen Resource Facility for longer-term off site specimen storage and retrieval. The Biorepository Core of the Center for Molecular Epidemiology at Dartmouth will coordinate all biospecimen triaging, processing, tracking, analytical preparation (including nucleic acid extraction), storage and retrieval to facilitate the needs of the four proposed projects. Additionally, personnel in the Core will provide education, training, consultation and specialized expertise to COBRE investigators. The accumulated biospecimens for all projects will involve thousands of diverse types of subject samples, with multiple aliquots, making the need for centralized, coordinated infrastructure to support these resources critically apparent. Web-based, interactive, searchable databases will be created to integrate the laboratory information systems and to coordinate de-identified specimen coding, tracking and retrieval, and to maintain accurate records of the availability of specimens for these projects. This will provide the researchers leading the four proposed research projects with standardized, appropriately maintained, high-quality biological samples central to their focus on understanding the molecular basis of complex disease interactions. This infrastructure will, in turn, provide the template for a comprehensive, coordinated institutional biorepository that will enhance cross-disciplinary translational research collaborations and the progression to personalized medical care.

生物样本是疾病及其宿主分子特征的基础，并且至关重要 用于现代分子流行病学研究。我们的目标是支持拟议的项目，作为 分子流行病学中心并建立一个最先进和可持续的生物样本库 国际竞争力。这将需要创建一个提供最佳管理和管理的基础设施 大规模、高效地监督人类生物样本。提出的最先进的生物样本库 该核心将安置在经 CLIA 认证、美国病理学家学院 (CAP) 认可的实验室中 将作为 COBRE 的一部分进行翻新。该核心还将开发最先进的生物样本 用于长期异地标本存储和检索的资源设施。 达特茅斯分子流行病学中心的生物样本库核心将协调所有 生物样本分类、处理、追踪、分析准备（包括核酸提取）、储存 和检索以满足四个拟议项目的需要。此外，核心人员将 为 COBRE 调查人员提供教育、培训、咨询和专业知识。这 所有项目积累的生物样本将涉及数千种不同类型的受试者样本， 多个等分部分，需要集中、协调的基础设施来支持这些资源 非常明显。将创建基于网络的、交互式的、可搜索的数据库来整合实验室 信息系统，协调去识别化样本编码、跟踪和检索，并维护 这些项目的样本可用性的准确记录。这将为研究人员提供领先的 拟议的四个研究项目具有标准化、适当维护、高质量的生物 样本对于他们关注复杂疾病相互作用的分子基础至关重要。这 反过来，基础设施将为全面、协调的机构生物样本库提供模板 这将加强跨学科转化研究合作以及个性化研究的进展 医疗保健。