Design and Simulation of Valvular Replacement Biomaterials

瓣膜置换生物材料的设计与模拟

基本信息

批准号：
8837675
负责人：
JOSEPH H GORMAN
金额：
$ 57.02万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-20 至 2017-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8837675
关键词：
Aftercare Animals Anterior Biocompatible Materials Biocompatible Materials Testing Biomechanics Bioprosthesis device Blood Cardiovascular system Cattle Chemicals Chemistry Clinical Collagen Collagen Fiber Coupled Deterioration Development Devices Elastin Engineering Enzyme Inhibitor Drugs Enzyme Inhibitors Ethanol Evaluation Extracellular Matrix Failure Family suidae Fatigue Fiber Funding Future GAG Gene Glutaral Goals Heart Valves Image Implant In Vitro Measurement Mechanics Mediating Methods Mitral Valve Modeling Neomycin Operative Surgical Procedures Outcome Performance Positioning Attribute Prevention Process Property Prosthesis Research Personnel Resistance Resolution Science Shapes Stress Structure Techniques Technology Time Tissues Translating United States National Institutes of Health Validation Work Xenograft procedure alcohol response aortic valve base biomaterial development calcification crosslink design experience hemodynamics improved in vivo innovation mechanical behavior microCT mineralization mitral valve replacement model development multidisciplinary novel novel strategies pericardial sac predictive modeling response sample fixation simulation

项目摘要

Summary: For the foreseeable future, bioprosthetic heart valves (BHV) fabricated from xenograft biomaterials will remain the dominant replacement prosthetic valve design. However, BHV durability remains limited to 10-15 years. Failure is usually the result of leaflet tructural deterioration mediated by fatigue and/or tissue mineralization. Thus, independent of valve design specifics (e.g. standard stented valve, percutaneous delivery), the development of novel xenograft biomaterials with improved durability remains an important clinical goal. This represents a unique cardiovascular engineering challenge resulting from the extreme valvular mechanical demands that occur with blood contact. Yet, current BHV assessment relies exclusively on device-level evaluations, which are confounded by simultaneous and highly coupled biomaterial mechanical behaviors and fatigue, valve design, hemodynamics, and calcification. Thus, despite decades of clinical BHV usage and growing popularity, there exists no acceptable method for assessing and simulating BHV durability at the component biomaterial level. This situation has contributed to the current stagnation in BHV biomaterial development, limiting rationally developed improvements in BHV durability. We hypothesize that a biomechanically rigorous and physiologically realistic in-vivo approach can be developed for a mechanistic understanding of intrinsic BHV biomaterial performance. Once developed, such an approach can be used to rationally design novel biomaterials that significantly improve BHV durability. While calcification prevention has not been completely solved, ethanol post-treatment has been shown to strongly reduce its onset. Moreover, others and we have shown that tissue degeneration is a major independent mechanism underlying BHV limited durability both in-vitro and in-vivo. Thus, our focus will be on mechanisms of early tissue degeneration and means to reduce damage accumulation, leading to improving BHV durability.

概括：在可预见的未来，由异种移植生物材料制造的生物假发心脏瓣膜（BHV）将是主要的替代假体瓣膜设计。但是，BHV耐用性仍然限制为10 - 15年。失败通常是通过疲劳和/或组织矿化介导的传单推力恶化的结果。因此，独立于阀门设计细节（例如标准支架阀，经皮递送），具有提高耐用性的新型异种移植生物材料的发展仍然是一个重要的临床目标。这代表了由于血接触而产生的极端瓣膜机械需求引起的独特心血管工程挑战。然而，当前的BHV评估仅依赖于设备级别的评估，这些评估与同时且高度耦合的生物材料机械行为和疲劳，瓣膜设计，血液动力学和钙化混淆。因此，尽管数十年的临床BHV使用和日益普及，但仍未接受可接受的方法来评估和模拟组成生物材料水平的BHV耐用性。这种情况有助于当前的BHV生物材料发展中停滞，限制了BHV耐用性的合理提高。我们假设可以开发出一种生物力学严格和生理现实的体内方法，以便对内在的BHV生物材料性能进行机械理解。一旦开发，这种方法可用于合理设计新型的生物材料，可显着提高BHV耐用性。虽然预防钙化预防尚未完全解决，但乙醇后处理已显示出强烈减少其发作。此外，其他人也表明，组织变性是BHV基础的主要独立机制有限的耐久性和体内的耐用性。因此，我们的重点将放在早期组织变性的机制上，并减少损害积累的方法，从而提高BHV耐用性。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Dynamic and fluid-structure interaction simulations of bioprosthetic heart valves using parametric design with T-splines and Fung-type material models.

DOI：
10.1007/s00466-015-1166-x
发表时间：
2015-06
期刊：
Computational mechanics
影响因子：
4.1
作者：
Hsu MC;Kamensky D;Xu F;Kiendl J;Wang C;Wu MC;Mineroff J;Reali A;Bazilevs Y;Sacks MS
通讯作者：
Sacks MS

Fluid-structure interaction analysis of bioprosthetic heart valves: Significance of arterial wall deformation.

DOI：
10.1007/s00466-014-1059-4
发表时间：
2014-10
期刊：
COMPUTATIONAL MECHANICS
影响因子：
4.1
作者：
Hsu, Ming-Chen;Kamensky, David;Bazilevs, Yuri;Sacks, Michael S.;Hughes, Thomas J. R.
通讯作者：
Hughes, Thomas J. R.

Fixation of Bovine Pericardium-Based Tissue Biomaterial with Irreversible Chemistry Improves Biochemical and Biomechanical Properties.

DOI：
10.1007/s12265-017-9733-5
发表时间：
2017-04
期刊：
Journal of cardiovascular translational research
影响因子：
3.4
作者：
Tam H;Zhang W;Infante D;Parchment N;Sacks M;Vyavahare N
通讯作者：
Vyavahare N

Modeling the response of exogenously crosslinked tissue to cyclic loading: The effects of permanent set.

模拟外源交联组织对循环载荷的响应：永久变形的影响。

DOI：
10.1016/j.jmbbm.2017.07.013
发表时间：
2017
期刊：
Journal of the mechanical behavior of biomedical materials
影响因子：
3.9
作者：
Zhang,Will;Sacks,MichaelS
通讯作者：
Sacks,MichaelS

An immersogeometric variational framework for fluid-structure interaction: application to bioprosthetic heart valves.

DOI：
10.1016/j.cma.2014.10.040
发表时间：
2015-02-01
期刊：
Computer methods in applied mechanics and engineering
影响因子：
7.2
作者：
Kamensky D;Hsu MC;Schillinger D;Evans JA;Aggarwal A;Bazilevs Y;Sacks MS;Hughes TJ
通讯作者：
Hughes TJ