RAPID FIELD TEST FOR IODINE LEVELS IN SALT

盐中碘含量的快速现场测试

基本信息

批准号：
8904051
负责人：
BIKAS VAIDYA
金额：
$ 48.54万
依托单位：
LYNNTECH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-15 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8904051
关键词：
Address Adopted Africa Asia Back Biological Markers Calibration Chemicals Child Collaborations Color Community Health Consumption Country County Detection Developed Countries Developing Countries Devices Disease Ensure Evaluation Face Far East Feedback Fetus Film Health Housing Hypothyroidism Individual Infant International International Agencies Intervention Interview Iodides Iodine Laboratories Latin America Letters Liquid substance Logistics Mental Retardation Methods Monitor Optical Readers Optics Performance Persons Phase Population Pregnant Women Procedures Production Program Development Property Reader Reading Reagent Research Research Infrastructure Resources Risk Rural Shipping Ships Site Small Business Innovation Research Grant Sodium Chloride Solutions South Africa Staging Testing Training UNICEF United States National Institutes of Health Validation Work chemical reaction combat commercialization cost design dietary salt fortification hazard intervention program iodine deficiency syndrome iodized salt member mental development nutrition operation prevent programs prototype reagent testing rural area

项目摘要

DESCRIPTION (provided by applicant): Nearly 2 billion people (mostly in Africa, South East Asia and Latin America) have inadequate iodine nutrition. Pregnant women and children are most at risk from iodine deficiency disorders (IDD), which occur as a range of abnormalities including hypothyroidism which impairs mental development in the fetus and in infants. Iodine deficiency disorders have been greatly reduced in industrialized countries through routine addition of iodine to table salt, a practice that started in the 1920's. Recently, the internationa health community has been striving to implement salt iodization programs in the rural areas of developing counties where the populations remain at risk from IDD. There are many challenges. Developing countries are typically served by a network of individual artisanal salt producers using low tech production methods and poorly administered distribution channels. In these situations international and regional health agencies need viable methods to check salt iodine levels in the field at multiple salt production sites and at points along the distribution chain. Laboratory test methods cannot be used in these situations and existing test kits for iodine have significant limitations. Lacking critical information whether their efforts to introduce iodine int salt at the prescribed levels are succeeding, IDD intervention programs can become ineffective or breakdown entirely. Working with coordinators from the International Council for the Control of Iodine Deficiency Disorders (ICCIDD) we have devised a salt iodine test kit specifically for low resource (rural) settings in developing countries. The test kit uses dry (stable) test reagents tha are incorporated into a uniquely layered multi- reagent cartridge. A chemical reaction sequence is essentially "programmed" into the cartridge eliminating user intervention and the need to handle liquid reagents. Additional merits include: detection of both iodine and iodate over the required range (5-100 ppm), the cartridges and associated reader are low cost items and easy to produce on a large scale. This Phase II proposal describes research necessary to transition the test kit into a functional prototype and includes provision for independent evaluation and feedback from international experts on iodine deficiency disorders.

描述（由申请人提供）：近 20 亿人（主要在非洲、东南亚和拉丁美洲）碘营养不足。孕妇和儿童最容易罹患碘缺乏病 (IDD)，这种疾病表现为一系列异常现象，包括损害胎儿和婴儿智力发育的甲状腺功能减退症。通过在食盐中常规添加碘（这一做法始于 1920 年代），工业化国家的碘缺乏病已大大减少。最近，国际卫生界一直在努力在发展中国家的农村地区实施食盐加碘计划，这些地区的人口仍然面临碘缺乏病的风险。有很多挑战。发展中国家通常由个体手工盐生产商网络提供服务，使用低技术生产方法和管理不善的分销渠道。在这些情况下，国际和区域卫生机构需要采取可行的方法来检查多个盐生产地点和分销链各点的现场盐碘水平。在这些情况下不能使用实验室测试方法，并且现有的碘测试套件具有很大的局限性。由于缺乏关键信息，以确定他们在规定水平上摄入碘和盐的努力是否成功，IDD 干预计划可能会变得无效或完全失败。我们与国际碘缺乏病控制理事会 (ICCIDD) 的协调员合作，设计了专门针对低碘缺乏症的盐碘检测试剂盒。发展中国家的资源（农村）环境。该测试套件使用干燥（稳定）的测试试剂，这些试剂被合并到一个独特的分层多试剂盒中。化学反应序列基本上被“编程”到盒中，消除了用户干预和处理液体试剂的需要。其他优点包括：在所需范围（5-100 ppm）内检测碘和碘酸盐，检测盒和相关读取器成本低廉，易于大规模生产。该第二阶段提案描述了将检测试剂盒转变为功能原型所需的研究，并包括国际碘缺乏病专家的独立评估和反馈的规定。