Response to Unpredictable Threat in Alcohol Dependence and Panic Disorder

对酒精依赖和恐慌症中不可预测的威胁的反应

• 批准号: 8784054
• 负责人: Stephanie Gorka
• 金额: $ 4.31万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8784054
• 关键词: Affective; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcohols; Anti-Anxiety Agents; Anxiety; Area; Chemosensitization; Clinical; Comorbidity; Development; Disease; Dropout; Economics; Electromyography; Emotional; Exhibits; Fellowship; Goals; Individual; Individual Differences; Intervention; Knowledge; Lead; Literature; Maintenance; Mediating; Mediator of activation protein; Mentorship; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Outcome; Panic Attack; Panic Disorder; Play; Population; Prevention; Process; Psychologist; Psychopathology; Psychophysiology; Public Health; Recording of previous events; Recovery; Recruitment Activity; Regulation; Relapse; Relative (related person); Research; Research Personnel; Rest; Risk Factors; Role; Shock; Sinus Arrhythmia; Statistical Methods; Strategic Planning; Sum; Time; Training; Work; base; biobehavior; career; chronic alcohol ingestion; drinking; experience; habituation; meetings; programs; public health relevance; respiratory; response; skills; social

DESCRIPTION (provided by applicant): The goals of this fellowship are to further develop the applicant's knowledge and research skills in comorbid psychopathology, psychophysiology, and advanced statistical methods. In line with these goals, the cornerstone of the applicant's training will be the daily activities associated with the proposed study of psychophysiological processes underlying comorbid alcohol dependence (AD) and panic disorder (PD). The project will serve as the applicant's dissertation work and allow her to pursue her goal of becoming an independent investigator with a translational program of research on biobehavioral processes associated with comorbid substance use and internalizing disorders. As the skills of an academic clinical psychologist are multidimensional, the proposed training plan also includes course work, regular sponsor meetings, clinical practica, and professional development activities. In addition to the skills to be gained by the applicant, the project also has the potenial to greatly advance our understanding of the processes underlying comorbid AD and PD, a goal consistent with several facets of both NIAAA's and NIMH's strategic plans. This area of research is also noteworthy given that AD-PD is associated with costly social and economic consequences and thus, is of the utmost public health significance. It has recently been postulated that alcohol's ability to dampen anticipatory anxiety between unpredictable panic attacks may be a core mechanism in AD-PD. Evidence also suggest that individuals with AD-PD may exhibit heightened aversive reactivity in response to anticipatory anxiety relative to PD-only individuals. However, this question has yet to be directly examined and few studies have assessed how aversive responses change over time. Research further suggests that prolonged alcohol use causes deficits in respiratory sinus arrhythmia (RSA), an important factor associated with aversive responding, which may subsequently lead to heightened reactivity/responding to anticipatory anxiety. As such, the specific aims of the study are to examine whether: 1) AD-PD individuals exhibit increased reactivity to unpredictable threat (i.e., anticipatory anxiety) compared with PD-only individuals, 2) AD-PD individuals exhibit a different time course of aversive responding during unpredictable threat (e.g., less habituation) compared with PD-only individuals, and 3) RSA mediates these associations. Forty-five individuals with AD-PD and 45 individuals with PD-only will be recruited for the present study and responses to unpredictable threat will be assessed using a well-established EMG startle paradigm. Mentorship for this project will be provided by experts in the areas of psychophysiology and comorbid psychopathology. The sponsors are Drs. Shankman and Kassel and the consultants are Drs. Curtin and Porges. This fellowship will not only be an important step in the applicant's research career, but if the hypotheses are supported, it would suggest that reactivity/responding to anticipatory anxiety may be a potential risk factor or consequence of AD- PD and thus, may aid in the development of targeted interventions for this difficult-to-treat population.

描述（由申请人提供）：该奖学金的目标是进一步发展申请人在合并症心理病理学，心理生理学和高级统计方法方面的知识和研究技能。符合这些目标，申请人培训的基石 将是与合并症依赖（AD）和恐慌症（PD）的心理生理过程研究相关的日常活动。该项目将充当申请人的论文工作，并允许她追求自己成为独立研究者的目标，该研究人员的转化计划是针对与合并症药物使用和内部化疾病相关的生物行为过程的研究计划。由于学术心理学家的技能是多维的，因此拟议的培训计划还包括课程工作，定期赞助者会议，临床实践和专业发展活动。除了申请人要获得的技能外，该项目还具有极大的能力，可以极大地促进我们对合并广告和PD的过程的理解，这是与NIAAA和NIMH战略计划的几个方面一致的目标。鉴于AD-PD与昂贵的社会和经济后果有关，因此这一研究领域也是公共健康意义的最大意义。最近有人认为，酒精在不可预测的惊恐发作之间抑制预期焦虑的能力可能是AD-PD的核心机制。证据还表明，患有AD-PD的个体可能会表现出相对于仅PD个体的预期焦虑的反应性厌恶反应性。但是，这个问题尚未直接研究，很少有研究评估了厌恶反应如何随着时间而变化。研究进一步表明，长时间的酒精使用会导致呼吸窦性心律不齐（RSA）的缺陷，这是与厌恶反应相关的重要因素，随后可能导致反应性增加/对预期焦虑的反应。 As such, the specific aims of the study are to examine whether: 1) AD-PD individuals exhibit increased reactivity to unpredictable threat (i.e., anticipatory anxiety) compared with PD-only individuals, 2) AD-PD individuals exhibit a different time course of aversive responding during unpredictable threat (e.g., less habituation) compared with PD-only individuals, and 3) RSA mediates these associations.将使用良好的EMG惊吓范式评估45名患有AD-PD和45名仅有PD的人进行本研究，并对不可预测的威胁进行招募。该项目的指导将由心理生理学和合并症心理病理学领域的专家提供。赞助商是Drs。 Shankman和Kassel以及顾问是Drs。科丁和廊。该奖学金不仅将是申请人研究生涯中的重要一步，而且如果支持假设，这表明反应性/应对预期焦虑可能是AD-PD的潜在危险因素或后果，因此，可能有助于为这种困难接受的人群开发目标干预措施。