Device to mechanically interrogate tissue and skin across research environments

在研究环境中机械询问组织和皮肤的设备

• 批准号: 8515408
• 负责人: Qi Wang
• 金额: $ 16.78万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8515408
• 关键词: Animal Experimentation; Animal Model; Animals; Applied Research; Area; Biopsy; Clinic; Clinical; Clinical Research; Collagen; Computer software; Contusions; Decubitus ulcer; Development; Devices; Diagnosis; Diagnostic; Disease; Edema; Elastomers; Engineering; Environment; Health Services Research; Healthcare; Home visitation; House Call; Human; Image; Isometric Exercise; Isotonic Exercise; Limb structure; Lower Extremity; Lymphatic; Manuals; Measurement; Measures; Mechanics; Methods; Microscopic; Modeling; Necrosis; Output; Palpation; Pathology; Pattern; Performance; Positioning Attribute; Property; Rattus; Readiness; Relative (related person); Reporting; Research; Research Personnel; Skin; Skin Tissue; Staging; Techniques; Technology; Testing; Tissues; Translational Research; Vascular Diseases; Venous; Work; base; clinical application; cost; design; diabetic; in vivo; innovation; instrument; iterative design; meetings; response; soft tissue; success; tissue phantom; tool; usability; wound

DESCRIPTION (provided by applicant): Device to mechanically interrogate tissue and skin across research environments Relative changes in the tissue's response to mechanical deformation have been used for centuries to diagnose and classify diseases and often serve as surrogates for assessment of disease stage or progression. Pathological conditions such as arterial, venous, diabetic, lymphatic and collagen vascular disease are manifested in macroscopic and microscopic structural changes in the skin and soft tissues. Many devices have been designed to measure and describe the mechanical properties of skin in vivo and some devices have attained success in certain research environments. However, a remaining need exists for a device that is compatible with both lab-based and clinically-based research. Current device have not been proven useful for both types of research environments. In this project, we will develop a low-cost, portable technology, the mechanical interrogation of tissue and skin device (MITS), to quickly and accurately quantify the mechanical properties of the tissue and skin within a variety of healthcare research settings. Because skin and tissue research spans a wide range of clinical conditions, in this project we must focus on a few examples in order to develop MITS for versatile and wide ranging applications. Specifically, we will 1) Engineer the MITS hardware and software for multiple research applications and environments, 2) Model and optimize MITS performance using tissue phantoms, 3) Optimize MITS for use in animal (wound) and human (pressure ulcer and edematous limb) research utilizing an iterative design approach. The novelty of the MITS device is its small form factor, small area of interrogation, high bandwidth, and its readiness to utilize variable excitation patterns. While this project is focused on developing a versatile research instrument, the simplicity and small form factor of the MITS can form the basis for the development of a clinical diagnostic device. Since a design objective includes utility in a variety of clinical research environments, one can envision later development work to focus on clinical applications. The potential of having a clinical tool based upon the same technical principles of a research instrument would streamline the translation of research findings into clinical applications.

描述（由申请人提供）：在研究环境中机械询问组织和皮肤的装置几个世纪以来，组织对机械变形响应的相对变化一直被用来诊断和分类疾病，并且通常用作评估疾病阶段或进展的替代指标。动脉、静脉、糖尿病、淋巴和胶原血管疾病等病理状况表现为皮肤和软组织的宏观和微观结构变化。许多设备被设计用于测量和描述体内皮肤的机械特性，并且一些设备在某些研究环境中取得了成功。然而，仍然需要一种与基于实验室和基于临床的研究兼容的设备。目前的设备尚未被证明对这两种类型的研究环境都有用。在这个项目中，我们将开发一种低成本、便携式技术，即组织和皮肤机械询问装置 (MITS)，以快速、准确地量化各种医疗保健研究环境中组织和皮肤的机械特性。由于皮肤和组织研究涉及广泛的临床条件，因此在该项目中，我们必须重点关注几个示例，以便开发用于多功能和广泛应用的 MITS。具体来说，我们将 1) 为多种研究应用和环境设计 MITS 硬件和软件，2) 使用组织模型建模和优化 MITS 性能，3) 优化 MITS 以用于动物（伤口）和人类（压疮和水肿肢体）利用迭代设计方法进行研究。 MITS 设备的新颖之处在于其外形尺寸小、询问面积小、带宽高且易于利用可变激励模式。虽然该项目的重点是开发多功能研究仪器，但 MITS 的简单性和小型化可以构成临床诊断设备开发的基础。由于设计目标包括在各种临床研究环境中的实用性，因此可以设想以后的开发工作将重点放在临床应用上。拥有基于与研究仪器相同技术原理的临床工具的潜力将简化研究成果向临床应用的转化。