MOLECULAR IMAGING DIRECTED, 3D ULTRASOUND-GUIDED, BIOPSY SYSTEM

分子成像引导、3D 超声引导活检系统

• 批准号: 9677767
• 负责人: BAOWEI FEI
• 金额: $ 14.12万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9677767
• 关键词: MOLECULAR; IMAGING; DIRECTED; 3D; ULTRASOUND

Prostate cancer affects 1 in 6 men in the USA. Every man over the age of 45 is at risk for prostate cancer. Systematic transrectal ultrasound (TRUS)-guided biopsy is the standard method for a definitive diagnosis of prostate cancer. More than 1.2 million prostate biopsies are performed annually and the medical cost is more than two billion dollars each year. However, this technique has a significant sampling error and is characterized by low sensitivity (39-52%). This "blind" biopsy approach can miss 30% of prostate cancers. As a negative biopsy does not preclude the possibility of a missed cancer, both the physicians and patients face challenges in making treatment decisions. Due to the increasing number of younger men with potentially early and curable prostate cancer, this problem must be addressed in order to improve cancer detection rate. At our NIH/NCI-supported Emory Molecular and Translational Imaging Center, positron emission tomography (PET) with a new molecular imaging tracer FACBC has shown very promising results for prostate cancer detection in human patients. We hypothesize that FACBC PET molecular images can be incorporated into ultrasound-guided biopsy for improved cancer detection. The proposed research is to develop a molecular image-directed, 3D ultrasound-guided system for targeted biopsy of the prostate. Specific Aim 1: To modify a real-time, mechanically assisted, 3D ultrasound-guided device. Compared to conventional 2D image guidance, 3D images of the prostate will be used to guide the biopsy. Specific Aim 2: To develop fast deformable and statistical appearance model based segmentation methods for 3D ultrasound images of the prostate. Statistical shape models will be developed from our database and will be used to guide automatic segmentation of the prostate. Specific Aim 3: To combine FACBC molecular images with 3D ultrasound for targeted biopsy. New deformable image registration methods based joint saliency map and fuzzy point correspondence will be developed in order to solve major limitations of mutual information based image registration. Specific Aim 4: To test the accuracy of the integrated biopsy system in phantoms and animals. The complete biopsy system will also be tested in a small number of human patients. Our FACBC patient studies are supported by the NIH-sponsored imaging center program (P50CA128301) and by the Phase II Clinical Trial (NCT00562315). The mechanically assisted device has received the FDA 510K approval. The proposed study will promote the academic-industrial collaboration (Emory University, Robarts Research Institute of the University of Western Ontario, and Eigen Inc., Grass Valley, CA). If completely developed, the multimodality molecular image-guided system will be able to be used not only for biopsy but also for brachytherapy, radiofrequency thermal ablation, cryotherapy, and photodynamic therapy.

在美国，前列腺癌影响了六分之一的男性。 45岁以上的每个人都有前列腺癌的风险。 系统的转直肠超声（TRUS）指导活检是确定性诊断的标准方法 前列腺癌。每年进行超过120万个前列腺活检，医疗费用为 每年超过20亿美元。但是，该技术有明显的采样误差，是 以低灵敏度为特征（39-52％）。这种“盲”活检方法可能会错过30％的前列腺 癌症。由于阴性活检并不能排除遗体癌症的可能性，因此两位医生 患者在做出治疗决策方面面临挑战。由于年轻人的数量增加 有了潜在的早期和可治愈的前列腺癌，必须解决此问题才能改善 癌症检测率。 在我们的NIH/NCI支持的Emory分子和翻译成像中心，正电子发射 带有新分子成像示踪剂FACBC的断层扫描（PET）显示出非常有希望的结果 人类患者的前列腺癌检测。我们假设FACBC PET分子图像可以是 纳入超声引导活检中，以改善癌症检测。拟议的研究是 开发一个分子图像指导的3D超声引导系统，以靶向前列腺活检。 特定目标1：修改实时辅助的3D超声引导设备。相比 常规的2D图像指导，前列腺的3D图像将用于指导活检。具体目标 2：开发3D的快速变形和统计外观模型的分割方法 前列腺的超声图像。统计形状模型将从我们的数据库开发，并将 用于指导前列腺的自动分割。特定目标3：结合FACBC分子 具有3D超声检查的图像。基于新的可变形图像注册方法的关节 将开发出显着图和模糊点的对应关系，以解决主要局限性 基于信息的图像注册。特定目标4：测试集成活检的准确性 幻影和动物的系统。完整的活检系统也将以少数数量进行测试 人类患者。我们的FACBC患者研究得到了NIH赞助的成像中心计划的支持 （P50CA128301）和II期临床试验（NCT00562315）。机械辅助设备具有 获得了FDA 510K批准。拟议的研究将促进学术工业合作 （埃默里大学（Emory University），罗巴特（Robarts 加利福尼亚山谷）。如果完全发展，多模式的分子图像引导系统将能够 不仅用于活检，还用于近距离放射治疗，射频热消融，冷冻疗法和 光动力疗法。

项目成果

A robust and accurate center-frequency estimation (RACE) algorithm for improving motion estimation performance of SinMod on tagged cardiac MR images without known tagging parameters.

• DOI: 10.1016/j.mri.2014.07.005
• 发表时间: 2014-11
• 期刊: Magnetic resonance imaging
• 影响因子: 2.5
• 作者: Liu H;Wang J;Xu X;Song E;Wang Q;Jin R;Hung CC;Fei B
• 通讯作者: Fei B

Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer.

• DOI: 10.1021/nn402199g
• 发表时间: 2013-08-27
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Zhen Z;Tang W;Guo C;Chen H;Lin X;Liu G;Fei B;Chen X;Xu B;Xie J
• 通讯作者: Xie J

Determining Cardiac Fiber Orientation Using FSL and Registered Ultrasound/DTI volumes.

使用 FSL 和配准超声/DTI 体积确定心纤维方向。

• DOI: 10.1117/12.2217296
• 发表时间: 2016
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Dormer,James;Qin,Xulei;Shen,Ming;Wang,Silun;Zhang,Xiaodong;Jiang,Rong;Wagner,MaryB;Fei,Baowei
• 通讯作者: Fei,Baowei

A wavelet multiscale denoising algorithm for magnetic resonance (MR) images.

• DOI: 10.1088/0957-0233/22/2/025803
• 发表时间: 2011-02-01
• 期刊: Measurement science & technology
• 影响因子: 2.4
• 作者: Yang X;Fei B
• 通讯作者: Fei B

Random Walk Based Segmentation for the Prostate on 3D Transrectal Ultrasound Images.

基于随机游走的 3D 经直肠超声图像前列腺分割。

• DOI: 10.1117/12.2216526
• 发表时间: 2016
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Ma,Ling;Guo,Rongrong;Tian,Zhiqiang;Venkataraman,Rajesh;Sarkar,Saradwata;Liu,Xiabi;Nieh,PeterT;Master,VirajV;Schuster,DavidM;Fei,Baowei
• 通讯作者: Fei,Baowei