MOLECULAR IMAGING DIRECTED, 3D ULTRASOUND-GUIDED, BIOPSY SYSTEM

分子成像引导、3D 超声引导活检系统

• 批准号: 9677767
• 负责人: BAOWEI FEI
• 金额: $ 14.12万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9677767
• 关键词: MOLECULAR; IMAGING; DIRECTED; 3D; ULTRASOUND

Prostate cancer affects 1 in 6 men in the USA. Every man over the age of 45 is at risk for prostate cancer. Systematic transrectal ultrasound (TRUS)-guided biopsy is the standard method for a definitive diagnosis of prostate cancer. More than 1.2 million prostate biopsies are performed annually and the medical cost is more than two billion dollars each year. However, this technique has a significant sampling error and is characterized by low sensitivity (39-52%). This "blind" biopsy approach can miss 30% of prostate cancers. As a negative biopsy does not preclude the possibility of a missed cancer, both the physicians and patients face challenges in making treatment decisions. Due to the increasing number of younger men with potentially early and curable prostate cancer, this problem must be addressed in order to improve cancer detection rate. At our NIH/NCI-supported Emory Molecular and Translational Imaging Center, positron emission tomography (PET) with a new molecular imaging tracer FACBC has shown very promising results for prostate cancer detection in human patients. We hypothesize that FACBC PET molecular images can be incorporated into ultrasound-guided biopsy for improved cancer detection. The proposed research is to develop a molecular image-directed, 3D ultrasound-guided system for targeted biopsy of the prostate. Specific Aim 1: To modify a real-time, mechanically assisted, 3D ultrasound-guided device. Compared to conventional 2D image guidance, 3D images of the prostate will be used to guide the biopsy. Specific Aim 2: To develop fast deformable and statistical appearance model based segmentation methods for 3D ultrasound images of the prostate. Statistical shape models will be developed from our database and will be used to guide automatic segmentation of the prostate. Specific Aim 3: To combine FACBC molecular images with 3D ultrasound for targeted biopsy. New deformable image registration methods based joint saliency map and fuzzy point correspondence will be developed in order to solve major limitations of mutual information based image registration. Specific Aim 4: To test the accuracy of the integrated biopsy system in phantoms and animals. The complete biopsy system will also be tested in a small number of human patients. Our FACBC patient studies are supported by the NIH-sponsored imaging center program (P50CA128301) and by the Phase II Clinical Trial (NCT00562315). The mechanically assisted device has received the FDA 510K approval. The proposed study will promote the academic-industrial collaboration (Emory University, Robarts Research Institute of the University of Western Ontario, and Eigen Inc., Grass Valley, CA). If completely developed, the multimodality molecular image-guided system will be able to be used not only for biopsy but also for brachytherapy, radiofrequency thermal ablation, cryotherapy, and photodynamic therapy.

在美国，六分之一的男性患有前列腺癌。每个 45 岁以上的男性都有患前列腺癌的风险。 系统性经直肠超声 (TRUS) 引导下的活检是明确诊断的标准方法 前列腺癌。每年进行超过 120 万例前列腺活检，医疗费用为 每年超过20亿美元。但该技术存在较大的采样误差， 其特点是灵敏度低（39-52%）。这种“盲目”活检方法可能会漏掉 30% 的前列腺 癌症。由于活检阴性并不能排除漏诊癌症的可能性，两位医生 患者在做出治疗决定时面临挑战。由于年轻男性数量的增加 对于潜在的早期和可治愈的前列腺癌，必须解决这个问题才能改善 癌症检出率。 在我们 NIH/NCI 支持的埃默里分子和转化成像中心，正电子发射 使用新型分子成像示踪剂 FACBC 进行断层扫描 (PET) 已显示出非常有希望的结果 人类患者的前列腺癌检测。我们假设 FACBC PET 分子图像可以 纳入超声引导活检以改善癌症检测。拟议的研究是 开发分子图像引导的 3D 超声引导系统，用于前列腺的靶向活检。 具体目标 1：修改实时、机械辅助、3D 超声引导设备。相比 与传统的2D图像引导相比，前列腺的3D图像将用于引导活检。具体目标 2：开发基于快速变形和统计外观模型的 3D 分割方法 前列腺的超声图像。统计形状模型将从我们的数据库中开发出来，并将 用于指导前列腺的自动分割。具体目标3：结合FACBC分子 使用 3D 超声图像进行靶向活检。基于关节的新型变形图像配准方法 将开发显着图和模糊点对应关系以解决 基于互信息的图像配准。具体目标 4：测试集成活检的准确性 幻影和动物中的系统。完整的活检系统也将在少数情况下进行测试 人类患者。我们的 FACBC 患者研究得到 NIH 赞助的影像中心计划的支持 (P50CA128301) 和 II 期临床试验 (NCT00562315)。该机械辅助装置具有 获得 FDA 510K 批准。拟议的研究将促进学术与工业合作 （埃默里大学、西安大略大学 Robarts 研究所和 Eigen Inc.，Grass 加利福尼亚州山谷）。如果开发完成，多模态分子图像引导系统将能够 不仅用于活检，还用于近距离放射治疗、射频热消融、冷冻治疗和 光动力疗法。

项目成果

A robust and accurate center-frequency estimation (RACE) algorithm for improving motion estimation performance of SinMod on tagged cardiac MR images without known tagging parameters.

• DOI: 10.1016/j.mri.2014.07.005
• 发表时间: 2014-11
• 期刊: Magnetic resonance imaging
• 影响因子: 2.5
• 作者: Liu H;Wang J;Xu X;Song E;Wang Q;Jin R;Hung CC;Fei B
• 通讯作者: Fei B

Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer.

• DOI: 10.1021/nn402199g
• 发表时间: 2013-08-27
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Zhen Z;Tang W;Guo C;Chen H;Lin X;Liu G;Fei B;Chen X;Xu B;Xie J
• 通讯作者: Xie J

Determining Cardiac Fiber Orientation Using FSL and Registered Ultrasound/DTI volumes.

使用 FSL 和配准超声/DTI 体积确定心纤维方向。

• DOI: 10.1117/12.2217296
• 发表时间: 2016
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Dormer,James;Qin,Xulei;Shen,Ming;Wang,Silun;Zhang,Xiaodong;Jiang,Rong;Wagner,MaryB;Fei,Baowei
• 通讯作者: Fei,Baowei

A wavelet multiscale denoising algorithm for magnetic resonance (MR) images.

• DOI: 10.1088/0957-0233/22/2/025803
• 发表时间: 2011-02-01
• 期刊: Measurement science & technology
• 影响因子: 2.4
• 作者: Yang X;Fei B
• 通讯作者: Fei B

Random Walk Based Segmentation for the Prostate on 3D Transrectal Ultrasound Images.

基于随机游走的 3D 经直肠超声图像前列腺分割。

• DOI: 10.1117/12.2216526
• 发表时间: 2016
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Ma,Ling;Guo,Rongrong;Tian,Zhiqiang;Venkataraman,Rajesh;Sarkar,Saradwata;Liu,Xiabi;Nieh,PeterT;Master,VirajV;Schuster,DavidM;Fei,Baowei
• 通讯作者: Fei,Baowei