Preclinical cardiac imaging package for clinical SPECT systems

用于临床 SPECT 系统的临床前心脏成像包

基本信息

批准号：
8889715
负责人：
SCOTT DEAN METZLER
金额：
$ 74.59万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-24 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8889715
关键词：
Accounting Address Alloys Animals Atherosclerosis Beds Biological Biomedical Engineering Biomedical Research Budgets Calibration Cardiac Cardiology Cardiotoxicity Cardiovascular system Clinical Collaborations Collimator Communities Computer software Data Detection Devices Evaluation Feedback Future Gel Geometry Goals Head Heart Homing Hospitals Human Image Imaging Techniques Institution Interdisciplinary Study Iridium Letters Maintenance Mechanics Methods Modeling Molds Motion Mus Myocardial Ischemia Myocardial perfusion Myocardium Organ Pennsylvania Performance Perfusion Phase Photons Platinum Polymers Positioning Attribute Positron Positron-Emission Tomography Price Principal Investigator Property Protocols documentation Radioisotopes Rattus Reproducibility Research Research Personnel Research Project Grants Resolution Science Software Design Staging Stream System Techniques Technology Testing Tracer Translating Tube Tungsten Universities Woman advanced system base biomedical scientist calcification cardiovascular visualization chemotherapy cost data acquisition density design detector electronic data fatty acid metabolism image reconstruction imaging system improved instrument interest molecular imaging monocyte nanoparticle novel pre-clinical preference programs prototype reconstruction research study single photon emission computed tomography tool

项目摘要

DESCRIPTION (provided by applicant): The long-term objective of this Bioengineering Research Partnership proposal from the University of Pennsylvania (Penn) and Brigham and Women's Hospital (BWH) is to develop an optimized collimation system for preclinical cardiac imaging that offers higher performance than that of commercially available preclinical systems at a cost that is a small fraction of the price of stand-alone commercial systems~ we estimate this cost at about $97k (~15%). We will develop a complete preclinical conversion package for clinical triple-head scanners that users may already have or that can be leased from our corporate partner for about $40k/year, including the cost of maintenance. This cost is less than the maintenance cost alone for commercially available stand-alone preclinical scanners, without even considering the purchase or lease price of the machines. The proposed collimator tube will be fabricated from tungsten-polymer using rapid-prototyping and casting techniques~ the initial version of this tube will contain a large number (~150-200) of very high-density platinum- iridium alloy pinhole inserts optimized for preclinical cardiac imaging and will consist of two sections: (i) a high- resolution section providing reconstructed resolution of 0.5 mm or better and a sensitivity of about 0.5% over a field of view (FOV) appropriate for cardiac imaging, and (ii) a scout-imaging section with a larger FOV, but more modest resolution. The sections can be rapidly changed by robotically translating the tube axially. This combination will not only provide a scout image for accurate positioning of the heart, but will also acquire information about the activity distribution surrounding the heart tha would otherwise be truncated if using the high-resolution section alone. Future versions of the tube may contain additional sections to allow multi-stage imaging. One of the key concepts of this proposal is the use of square-aperture inserts to provide efficient tiling of projections fro multiple pinholes, as well as higher sensitivity than that of circular apertures for the same resolution. Because rapid-prototyping molds will be used for tube fabrication, these inserts will all be positioned and oriented to yield optimal imaging performance. Customized phantoms -- designed specifically for preclinical cardiac imaging tasks and also fabricated using rapid-prototyping techniques -- will be used for initial performance evaluations at both Penn and BWH, as well as for comparisons with other preclinical imaging systems. The new systems' utility for advancing cardiovascular science, as well as their full range of functionalit, will then be thoroughly demonstrated through multidisciplinary research studies with our biomedical collaborators~ these projects will provide essential feedback to the principal investigators for optimizing acquisition protocols, while also addressing important and timely topics in cardiovascular science, related to imaging of (i) perfusion with both sestamibi and a novel tracer in normal myocardium~ (ii) perfusion with both tracers in ischemic myocardium~ (iii)~ fatty-acid metabolism~ (iv) chemotherapy-induced cardiotoxicity~ (v) monocyte homing to atheroplaques~ and (vi) nanoparticles and calcifications in atherosclerosis.

描述（由申请人提供）：该生物工程研究合作伙伴提案的长期目标是宾夕法尼亚大学（宾夕法尼亚大学）和杨百翰及妇女医院（BWH），是为临床前心脏成像制定优化的准确系统，该系统比商业上的pressions of Corge of Becort of Corge Off $ flocy of forge of forge of forge of forge of forglinical of forge for，$ 9 （〜15％）。我们将为用户可能已经拥有的临床三头扫描仪开发一个完整的临床前转换套件，或者可以从我们的公司合作伙伴中以每年4万美元的价格租用，包括维护费用。该成本仅小于商业可用的独立临床前扫描仪的维护成本，甚至没有考虑机器的购买或租赁价格。提出的直接仪管将使用快速推出型来制造和铸造技术〜该管的初始版本将包含大量（〜150-200）的非常高密度的铂 - 硅藻合金针孔插入用于临床前心脏成像的优化的插件，并将由两个部分组成：（i）高分辨率部分，可提供0.5 mm或更高的固定量的高分辨率分辨率，并拟定了0.5 mm或更高的敏感性和一定数量的图像，并具有0.5％的范围（概要），并具有0.5％的图像（概要），该级别的范围是一定数量的。（ii）具有更大FOV但更适度分辨率的侦察成像部分。通过机器人在轴向上翻译管道，可以快速更改部分。这种组合不仅将提供童军图像以准确地定位心脏，而且还将获取有关单独使用高分辨率部分，否则将截断心脏周围的活动分布的信息。该管的未来版本可能包含其他部分，以允许多阶段成像。该提案的关键概念之一是使用方形插入物来通过多个针孔提供有效的投影瓷砖，并且比相同分辨率的圆形光圈更高的灵敏度。由于快速发射模具将用于管制造，因此这些插入物将被定位并定向以产生最佳成像性能。定制的幻像 - 专门为临床前心脏成像任务设计，也使用快速型型技术制造 - 将用于宾夕法尼亚州和BWH的初步性能评估，以及与其他临时性成像系统的比较。然后，将通过与我们 biomedical collaborators~ these projects will provide essential feedback to the principal investigators for optimizing acquisition protocols, while also addressing important and timely topics in cardiovascular science, related to imaging of (i) perfusion with both sestamibi and a novel tracer in normal myocardium~ (ii) perfusion with both tracers in ischemic myocardium~ (iii)~ fatty-acid metabolism~ (iv)化学疗法诱导的心脏毒性〜（v）单核细胞归巢于动脉粥样硬化和（VI）纳米颗粒和动脉粥样硬化中的钙化。