Preclinical cardiac imaging package for clinical SPECT systems

用于临床 SPECT 系统的临床前心脏成像包

基本信息

批准号：
8889715
负责人：
SCOTT DEAN METZLER
金额：
$ 74.59万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-24 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8889715
关键词：
Accounting Address Alloys Animals Atherosclerosis Beds Biological Biomedical Engineering Biomedical Research Budgets Calibration Cardiac Cardiology Cardiotoxicity Cardiovascular system Clinical Collaborations Collimator Communities Computer software Data Detection Devices Evaluation Feedback Future Gel Geometry Goals Head Heart Homing Hospitals Human Image Imaging Techniques Institution Interdisciplinary Study Iridium Letters Maintenance Mechanics Methods Modeling Molds Motion Mus Myocardial Ischemia Myocardial perfusion Myocardium Organ Pennsylvania Performance Perfusion Phase Photons Platinum Polymers Positioning Attribute Positron Positron-Emission Tomography Price Principal Investigator Property Protocols documentation Radioisotopes Rattus Reproducibility Research Research Personnel Research Project Grants Resolution Science Software Design Staging Stream System Techniques Technology Testing Tracer Translating Tube Tungsten Universities Woman advanced system base biomedical scientist calcification cardiovascular visualization chemotherapy cost data acquisition density design detector electronic data fatty acid metabolism image reconstruction imaging system improved instrument interest molecular imaging monocyte nanoparticle novel pre-clinical preference programs prototype reconstruction research study single photon emission computed tomography tool

项目摘要

DESCRIPTION (provided by applicant): The long-term objective of this Bioengineering Research Partnership proposal from the University of Pennsylvania (Penn) and Brigham and Women's Hospital (BWH) is to develop an optimized collimation system for preclinical cardiac imaging that offers higher performance than that of commercially available preclinical systems at a cost that is a small fraction of the price of stand-alone commercial systems~ we estimate this cost at about $97k (~15%). We will develop a complete preclinical conversion package for clinical triple-head scanners that users may already have or that can be leased from our corporate partner for about $40k/year, including the cost of maintenance. This cost is less than the maintenance cost alone for commercially available stand-alone preclinical scanners, without even considering the purchase or lease price of the machines. The proposed collimator tube will be fabricated from tungsten-polymer using rapid-prototyping and casting techniques~ the initial version of this tube will contain a large number (~150-200) of very high-density platinum- iridium alloy pinhole inserts optimized for preclinical cardiac imaging and will consist of two sections: (i) a high- resolution section providing reconstructed resolution of 0.5 mm or better and a sensitivity of about 0.5% over a field of view (FOV) appropriate for cardiac imaging, and (ii) a scout-imaging section with a larger FOV, but more modest resolution. The sections can be rapidly changed by robotically translating the tube axially. This combination will not only provide a scout image for accurate positioning of the heart, but will also acquire information about the activity distribution surrounding the heart tha would otherwise be truncated if using the high-resolution section alone. Future versions of the tube may contain additional sections to allow multi-stage imaging. One of the key concepts of this proposal is the use of square-aperture inserts to provide efficient tiling of projections fro multiple pinholes, as well as higher sensitivity than that of circular apertures for the same resolution. Because rapid-prototyping molds will be used for tube fabrication, these inserts will all be positioned and oriented to yield optimal imaging performance. Customized phantoms -- designed specifically for preclinical cardiac imaging tasks and also fabricated using rapid-prototyping techniques -- will be used for initial performance evaluations at both Penn and BWH, as well as for comparisons with other preclinical imaging systems. The new systems' utility for advancing cardiovascular science, as well as their full range of functionalit, will then be thoroughly demonstrated through multidisciplinary research studies with our biomedical collaborators~ these projects will provide essential feedback to the principal investigators for optimizing acquisition protocols, while also addressing important and timely topics in cardiovascular science, related to imaging of (i) perfusion with both sestamibi and a novel tracer in normal myocardium~ (ii) perfusion with both tracers in ischemic myocardium~ (iii)~ fatty-acid metabolism~ (iv) chemotherapy-induced cardiotoxicity~ (v) monocyte homing to atheroplaques~ and (vi) nanoparticles and calcifications in atherosclerosis.

描述（由申请人提供）：宾夕法尼亚大学 (Penn) 和布莱根妇女医院 (BWH) 提出的这项生物工程研究合作提案的长期目标是开发一种用于临床前心脏成像的优化准直系统，该系统提供比商用临床前系统的成本仅为独立商业系统价格的一小部分~我们估计该成本约为 97,000 美元（~15%）。我们将为临床三头扫描仪开发一个完整的临床前转换包，用户可能已经拥有该扫描仪，或者可以从我们的企业合作伙伴处以每年约 4 万美元的价格租赁该扫描仪，包括维护成本。该成本低于市售独立临床前扫描仪的单独维护成本，甚至不考虑机器的购买或租赁价格。拟议的准直器管将采用快速原型技术由钨聚合物制成和铸造技术〜该管的初始版本将包含大量（〜150-200）非常高密度的铂铱合金针孔插入物，针对临床前心脏成像进行了优化，并将由两个部分组成：（i）分辨率部分提供 0.5 毫米或更好的重建分辨率以及在适合心脏成像的视场 (FOV) 上约 0.5% 的灵敏度，以及 (ii) 具有更大 FOV 的侦察成像部分，但更温和的决议。通过机器人轴向平移管可以快速改变截面。这种组合不仅可以提供用于精确定位心脏的侦察图像，而且还将获取有关心脏周围活动分布的信息，否则如果单独使用高分辨率切片，这些信息可能会被截断。该管的未来版本可能包含额外的部分以允许多阶段成像。该提案的关键概念之一是使用方形孔径插入件来提供多个针孔投影的有效平铺，以及在相同分辨率下比圆形孔径更高的灵敏度。由于快速原型模具将用于管制造，因此这些插入件都将被定位和定向，以产生最佳的成像性能。定制模型——专为临床前心脏成像任务而设计，并使用快速原型技术制造——将用于宾夕法尼亚大学和 BWH 的初始性能评估，以及与其他临床前成像系统的比较。新系统对于推进心血管科学的实用性及其全方位的功能将通过我们的多学科研究得到彻底证明。生物医学合作者〜这些项目将为主要研究人员提供重要的反馈，以优化采集协议，同时也解决心血管科学中重要且及时的主题，与（i）正常心肌中塞他米比和新型示踪剂的灌注成像相关〜（ii） ) 缺血心肌中两种示踪剂的灌注 ~ (iii)~ 脂肪酸代谢 ~ (iv) 化疗引起的心脏毒性 ~ (v) 单核细胞归巢至动脉粥样硬化斑块 ~ 和(vi)动脉粥样硬化中的纳米粒子和钙化。