Arkansas Claude Pepper Older Americans Independence Center at UAMS

阿肯色州 UAMS 的美国老年人独立中心克劳德·佩珀

• 批准号: 8534660
• 负责人: JEANNE Y WEI
• 金额: $ 93.03万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8534660
• 关键词: Affect; Age; Aging; American; Arkansas; Basic Science; Caring; Clinical Research; Clinical Trials; Collaborations; Dietary Intervention; Disease; Elderly; Emerging Technologies; Functional disorder; Generations; Goals; Health; Individual; Institution; Intervention; Intervention Studies; Leadership; Learning; Methodology; Methods; Minority; Molecular; Muscle; Muscle Weakness; Muscle function; Myocardial; Myocardium; Nutrient; Nutritional; Outcome; Outreach Research; Performance; Prevention; Recommendation; Research; Research Personnel; Rural; Skeletal Muscle; Source; Supplementation; Technology; Therapeutic; Training; Translating; Translational Research; Translations; age related; base; career development; design; improved; innovation; multidisciplinary; next generation; novel; nutrition; prevent; protein metabolism; standard of care

The theme of the Arkansas OAIC at UAMS is "Translational research on cardiac and skeletal muscle dysfunction in aging and disease." The main goals of the Arkansas OAIC are 1) To promote research that will both provide a mechanistic understanding of the basis for declining skeletal muscle function and myocardial performance with advancing age and translate what is learned from those studies to intervention studies that will ultimately affect nutritional recommendations and standard of care in the elderly; 2) To introduce state-of-the-art methodologies for studying protein metabolism to better enable basic molecular-based studies to ultimately translate the findings to the performance of clinical trials aimed at improving outcomes in elderly individuals; 3) use novel nutritional interventions in the prevention and treatment of cardiac and skeletal muscle weakness; 4) To train a new generation of geriatricians and gerontologists in improving functional independence of older Americans through therapeutic nutritional interventions. These goals will be achieved via the following Specific Aims. Specific Aim 1. Provide scientific, intellectual, and innovation leadership among UAMS investigators. Specific Aim 2. Stimulate translation between basic and clinical research through collaboration and interaction among investigators to improve our understanding of mechanisms contributing to declining skeletal muscle function and myocardial performance with age. Interventions will include, but not be limited to, therapeutic nutrient supplementation. Specific Aim 3. Stimulate incorporation of emerging technologies and novel methods and approaches in analyzing protein metabolism and nutritional interventions for cardiac and skeletal muscle weakness. Specific Aim 4. Serve as a source of advice and collaboration to other institutions (especially OUHSC and other OAICs) regarding technology and expertise in the center theme of the proposal and facilitate multi- and interdisciplinary strategies. Specific Aim 5. Provide career development for future research leaders by increasing the recruitment of young and established investigators In aging, while emphasizing recruitment of minorities to UAMS. Specific Aim 6. Expand the research outreach to maximally include minority representation in all studies. This OAIC would help translate innovative muscle research to improve care, including for the rural elderly.

UAMS 阿肯色州 OAIC 的主题是“衰老和疾病中心脏和骨骼肌功能障碍的转化研究”。 阿肯色州 OAIC 的主要目标是 1) 促进研究，提供机制 了解随着年龄的增长骨骼肌功能和心肌性能下降的基础，并将从这些研究中学到的知识转化为干预研究，最终影响老年人的营养建议和护理标准； 2）引入最先进的蛋白质代谢研究方法，以更好地进行基础分子研究，最终将研究结果转化为旨在改善老年人预后的临床试验； 3）使用新型营养干预措施预防和治疗心肌和骨骼肌无力； 4) 培训新一代老年病学家和老年学家，通过治疗性营养干预提高美国老年人的功能独立性。 这些目标将通过以下具体目标来实现。 具体目标 1. 为 UAMS 研究者提供科学、智力和创新方面的领导力。 具体目标 2. 通过研究人员之间的合作和互动，促进基础研究和临床研究之间的转化，以提高我们对骨骼肌功能和心肌性能随年龄下降的机制的理解。干预措施包括但不限于治疗性营养补充。 具体目标 3. 鼓励采用新兴技术和新方法和方法来分析蛋白质代谢和针对心脏和骨骼肌无力的营养干预措施。 具体目标 4. 为其他机构（特别是 OUHSC 和其他 OAIC）提供关于提案中心主题的技术和专业知识的建议和协作来源，并促进多学科和跨学科战略。 具体目标 5. 通过增加年轻和成熟研究人员的招募，为未来的研究领导者提供职业发展，同时强调招募少数族裔加入 UAMS。 具体目标 6. 扩大研究范围，最大限度地在所有研究中纳入少数群体的代表性。 该 OAIC 将有助于转化创新的肌肉研究，以改善护理，包括对农村老年人的护理。