Optical imaging for radiation therapy dose verification on patients

用于患者放射治疗剂量验证的光学成像

• 批准号: 9132738
• 负责人: William Ware
• 金额: $ 57.17万
• 依托单位: DOSEOPTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9132738
• 关键词: Accidents; Algorithms; Area; Biological; Breast; Calibration; Cancer Patient; Clinical; Clinical Trials; Color; Complex; Computer software; Data; Data Collection; Detection; Development; Devices; Dimensions; Dose; Electrons; Ensure; Equipment; Goals; Head; Health; Human; Image; Imagery; Imaging Device; Imaging technology; Individual; Intensity-Modulated Radiotherapy; Interruption; Intervention; Lateral; Left; Legal patent; Licensing; Linear Accelerator Radiotherapy Systems; Maps; Measurement; Measures; Medical Imaging; Medicine; Methods; Monte Carlo Method; Movement; Nature; Patients; Performance; Phase; Physics; Process; Production; Publications; Quality Control; Radiation; Radiation Oncology; Radiation therapy; Records; Reporting; Research; Resolution; Safety; Site; Skin; Software Tools; Specific qualifier value; Surface; Surveys; System; Technology; Testing; Time; Tissues; Translating; Water; Work; base; college; cost; design; dosimetry; feeding; imaging system; improved; in vivo; ionization; irradiation; light emission; new technology; oncology; optical imaging; prevent; programs; prototype; skin color; software development; time use; tool; treatment planning; whole body imaging

 DESCRIPTION (provided by applicant): For the first time, it is possible to directly visualize a radiation beam incident upon a patient's tissue in real time, using Cerenkov emission imaging. This imaging could transform the ease for verifying delivery in radiation oncology, and allow on the fly reporting, recording and correction of replanning needs or delivery errors. In a field wher there is an incredibly high number of new technologies for delivery, the verification of delivery and recording of adverse incidents will become more and more critical and yet the ease of implementation must be improved. A recent discovery that gated intensified imaging allows video-rate passive detection of Cherenkov emission during radiation therapy with the room lights on, and so the delivery process is unaffected by the imaging system. This opens up a new important paradigm in radiation oncology verification. This work has been invented and patented at Dartmouth, and DoseOptics LLC is a company spin-off of this research program, with the goal to advance video-rate Cerenkov imaging as a dose delivery visualization & verification tool. The feasibility of the system has been proven through the technological refinement and pilot clinical trial at Dartmouth. The next phase of this work involves the DoseOptics prototype development as a C-Dose OnBoard verification tool for imaging patients during treatment from the view of the LINAC gantry. The system will be developed with a unique proprietary moderate cost design, which will then be tested in phantoms and with patient treatment plans delivered to water tanks. The system will have capabilities for video-rate capture of IMRT/VMAT data, tracking MLC movements in real time, and allowing analysis of treatment plans on a beam to beam basis. The competing technologies using ionization chambers or diode arrays are low resolution devices with limitations that they cannot eventually translate to direct on-patient imaging. The work carried out in the company is augmented by a plan to evaluate the system in Clinical Physics at Dartmouth, and be further evaluated at Stanford and UPenn. The technology patent protected as developed by this group, and for this start up, the team of developers includes a substantial number of experts in Cerenkov imaging, medical physics and new venture creation.

 描述（由适用提供）：首次可以使用Cerenkov发射成像直接实时可视化患者组织上的辐射束。这种成像可以改变验证辐射肿瘤学中传递的便利性，并允许在飞行报告，记录和校正重新融合需求或交货错误中。在一个领域，当有大量的新技术用于交付时，对不良事件的交付和记录的验证将变得越来越重要，但是必须提高实施的易用性。最近的发现，封闭式成像加剧允许视频速率被动检测在辐射疗法期间随着室灯的打开而对Cherenkov发射的发射，因此输送过程不受成像系统的影响。这打开了辐射肿瘤学验证中新的重要范式。这项工作已在达特茅斯（Dartmouth）发明和申请专利，Doseoptics LLC是该研究计划的公司衍生产品，其目标是推动视频速率Cerenkov成像作为剂量传递可视化和验证工具。该系统的可行性通过达特茅斯的技术改进和试点临床试验得到了证明。这项工作的下一阶段涉及剂型原型开发作为C剂量的板载验证工具，可从Linac Gantry的视野进行对患者进行成像。该系统将采用独特的专有现代成本设计开发，然后将在幻影和患者治疗计划中进行测试。该系统将具有视频速率捕获IMRT/VMAT数据的功能，实时跟踪MLC运动，并允许以光束进行横梁分析治疗计划。使用电离室或二极管阵列的竞争技术是低分辨率设备，其局限性最终无法转化为直接的现场成像。一项计划在达特茅斯（Dartmouth）评估该系统的计划增强了公司的研究，并在斯坦福大学和Upenn进行了进一步评估。该小组开发的技术专利保护，为此，开发人员团队包括大量Cerenkov成像，医疗物理和新的合资企业创建的专家。