Training Program in Lung Biology and Pathobiology
肺生物学和病理学培训计划
基本信息
- 批准号:8794209
- 负责人:
- 金额:$ 65.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1995
- 资助国家:美国
- 起止时间:1995-07-01 至 2020-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): This T32 renewal application for yrs to 22-26 seeks continuing support for our highly successful Lung Biology and Pathobiology Training Program at The University of Illinois College of Medicine, Chicago. The singular and concentrated emphasis of the Program continues to be to mentor, at a scientifically advanced level, a predoctoral (post-baccalaureate) and postdoctoral trainee cohort of new lung researchers as they develop into independent scientists with careers in academia, biopharmaceutical industry, or take advantage of a variety of newly evolving opportunities. Although the number of trainees is held constant and the dominant effort is in research training, the program is being expanded to include exposure to scientific research-related careers such as policymaking, teaching, administration, and journalism. The Program has a strong record of developing careers of outstanding scientists and promoting skills in critical scientific thinking and problem- solving. In addition t the cohort of stellar current preceptors, we have on the basis of targeted recent recruitments integrated new faculty members who bring exciting new perspectives. The Program provides in- depth multi- and cross-disciplinary research training where a seamless transition from basic to translational/clinical research projects is feasible and encouraged. The Program is designed to provide mentoring by a primary mentor however, based on specifics of the research project, a secondary mentor will participate as an equal partner. Once in the Program, the first order of business will be for the trainees will be to formulate an Individual Development Plan, with their mentor(s)' guidance. This will provide a road-map as the trainees mature by acquiring essential skills as they move towards greater independence. Each trainee's progress will be carefully and creatively monitored throughout training by their Trainee Advisory Committee, the Extramural Lung Seminar Series, and other less structured forums designed to promote dialog and interactions. The key activities of the Program include the Extramural Lung Seminar Series given by scientific leaders, Annual Retreat, Career Symposium, and a mandatory specifically designed Lung Biology Course. This application requests continued funding for 6 predoctoral and 6 postdoctoral trainees. The Program is grounded in 4 inter-related thematic areas of research training: (1) Lung Vascular Injury and Repair, (2) Stem Cells and Lung Regeneration and Repair, (3) Cellular and Humoral Bases of Lung Inflammation and Injury, and (4) Cell Signaling Mechanisms in Lung. We are poised with continued vigor to nurture and train a highly-qualified group of nascent scientists in an inspired, comprehensive environment in areas of lung- related research and areas that intersect with lung biology and pathobiology for careers in academia, research institutions, biopharmaceutical industry, and other burgeoning areas.
描述(由申请提供):T32续约22-26的续签申请寻求对我们在芝加哥伊利诺伊大学医学院的非常成功的肺部生物学和病理学培训计划的持续支持。该计划的奇异和集中的重点继续是精神上的,在科学先进的层面上,是新肺研究人员的新肺研究人员的研究人员和博士后学员队伍,因为他们从事学术界的独立科学家,从事学术界,生物制药行业的职业,或者利用各种新变化的机会。尽管学员的人数一直保持不变,并且在研究培训中的主要努力,但该计划正在扩大,包括接触与科学研究相关的职业,例如决策,教学,管理和新闻业。杰出的科学家和促进批判性科学思维和解决问题的技能。除了当前恒星当前的受体队伍之外,我们还基于有针对性的新兵融合了新的教职员工,他们带来了令人兴奋的新观点。该计划提供了深度和跨学科的研究培训,在该培训中,从基本到翻译/临床研究项目的无缝过渡是可行的和鼓励的。该计划旨在通过主要心态来提供心理,但是,根据研究项目的细节,次要心态将作为平等伴侣参与。一旦进入该计划,第一阶将是学员的一项工作,将在其心理指导下制定个人发展计划。这将通过获得更大独立性的基本技能来提供作为学员的路线图成熟。每个学员的进步将由他们的学员咨询委员会,校外肺部研讨会系列以及其他旨在促进对话和互动的结构较低的论坛进行仔细和创造性的监视。该计划的关键活动包括科学领导者提供的壁外肺研讨会系列,年度静修会,职业研讨会以及专门设计的肺部生物学课程。该申请要求继续为6名催眠前和6名博士后学员提供资金。该程序基于4个相互关联的研究培训领域:(1)肺血管损伤和修复,(2)干细胞以及肺部再生和修复,(3)肺部炎症和损伤的细胞和体液底座,以及(4)肺中的细胞信号机制。在肺部相关研究和领域的启发性,全面的环境中,我们持续着训练和培训一群较高的新生科学家,并与肺部生物学和病理学相交,以实现学术界,研究机构,研究机构,生物制药行业和其他繁忙的领域。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Asrar B. Malik其他文献
Tissue Regeneration Requires Edema Fluid Clearance by Compensatory Lymphangiogenesis in Zebrafish
斑马鱼的组织再生需要通过补偿性淋巴管生成清除水肿液
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Olamide Olayinka;Hannah Ryu;Xiaowei Wang;Asrar B. Malik;Hyun Min Jung - 通讯作者:
Hyun Min Jung
H<sub>2</sub>O<sub>2</sub> and Tumor Necrosis Factor-α Activate Intercellular Adhesion Molecule 1 (ICAM-1) Gene Transcription through Distinct <em>cis</em>-Regulatory Elements within the ICAM-1 Promoter
- DOI:
10.1074/jbc.270.32.18966 - 发表时间:
1995-08-11 - 期刊:
- 影响因子:
- 作者:
Kenneth A. Roebuck;Arshad Rahman;Venkatesh Lakshminarayanan;Kilambi Janakidevi;Asrar B. Malik - 通讯作者:
Asrar B. Malik
The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury
GTPase Rab1 是 NLRP3 炎症小体激活和炎症性肺损伤所必需的
- DOI:
10.4049/jimmunol.1800777 - 发表时间:
2018-11 - 期刊:
- 影响因子:4.4
- 作者:
Yuehui Zhang;Lijun Wang;Yang Lv;Chunling Jiang;Guangyu Wu;R;al O. Dull;Richard D. Minshall;Asrar B. Malik;Guochang Hu - 通讯作者:
Guochang Hu
Nitroglycerin-Induced Loss of Caveolin-1 Results in ENOS Dysfunction and Nitrate Tolerance
- DOI:
10.1016/j.freeradbiomed.2012.10.503 - 发表时间:
2012-11-01 - 期刊:
- 影响因子:
- 作者:
Mao Mao;Varadarajan Sudhahar;Tohru Fukai;Farnaz R. Bakhshi;Susan Varghese;Olga Chernaya;Xiaopei Gao;Asrar B. Malik;Richard D. Minshall;Samuel C. Dudley;Marcelo G. Bonini - 通讯作者:
Marcelo G. Bonini
62 - NOSl-Derived Nitric Oxide Promotes NF-kB Transcriptional Activity Through Inhibition of Suppressor of Cytokine Signaling (SOCS-1)
- DOI:
10.1016/j.freeradbiomed.2015.10.101 - 发表时间:
2015-10-01 - 期刊:
- 影响因子:
- 作者:
Marcelo G Bonini;Sofia V Zaichik;Mao Mao;Peter C Hart;Saurabh Chatterjee;Asrar B. Malik;John W Christman;Michelle L. Block;Richard D Minshall;Benjamin N Gantner - 通讯作者:
Benjamin N Gantner
Asrar B. Malik的其他文献
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{{ truncateString('Asrar B. Malik', 18)}}的其他基金
iPSC-Derived Vascularized Human Lung Organoids and Interaction Between Lung Endothelial Cells and Alveolar Epithelial Cells
iPSC 衍生的血管化人肺类器官以及肺内皮细胞和肺泡上皮细胞之间的相互作用
- 批准号:
10467249 - 财政年份:2022
- 资助金额:
$ 65.27万 - 项目类别:
Mechanisms and Treatment of SARS-CoV-2 induced Lung Endothelial Injury
SARS-CoV-2引起的肺内皮损伤的机制和治疗
- 批准号:
10559640 - 财政年份:2022
- 资助金额:
$ 65.27万 - 项目类别:
iPSC-Derived Vascularized Human Lung Organoids and Interaction Between Lung Endothelial Cells and Alveolar Epithelial Cells
iPSC 衍生的血管化人肺类器官以及肺内皮细胞和肺泡上皮细胞之间的相互作用
- 批准号:
10673199 - 财政年份:2022
- 资助金额:
$ 65.27万 - 项目类别:
E3 Ubiquitin Ligase CHFR Regulates Lung Endothelial Barrier Integrity and Innate Immunity through Control of VE-cadherin Expression
E3 泛素连接酶 CHFR 通过控制 VE-钙粘蛋白表达来调节肺内皮屏障完整性和先天免疫
- 批准号:
10706515 - 财政年份:2022
- 资助金额:
$ 65.27万 - 项目类别:
E3 Ubiquitin Ligase CHFR Regulates Lung Endothelial Barrier Integrity and Innate Immunity through Control of VE-cadherin Expression
E3 泛素连接酶 CHFR 通过控制 VE-钙粘蛋白表达来调节肺内皮屏障完整性和先天免疫
- 批准号:
10494617 - 财政年份:2022
- 资助金额:
$ 65.27万 - 项目类别:
Mechanisms and Treatment of SARS-CoV-2 induced Lung Endothelial Injury
SARS-CoV-2引起的肺内皮损伤的机制和治疗
- 批准号:
10390863 - 财政年份:2022
- 资助金额:
$ 65.27万 - 项目类别:
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury
急性肺损伤期间肺内皮炎症的放大机制
- 批准号:
10435435 - 财政年份:2021
- 资助金额:
$ 65.27万 - 项目类别:
Ion Flux Regulation of Macrophage Plasticity in Lung Injury and Repair
肺损伤与修复中巨噬细胞可塑性的离子通量调节
- 批准号:
10701929 - 财政年份:2021
- 资助金额:
$ 65.27万 - 项目类别:
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