Pulse oximetry for childhood pneumonia in rural Bangladesh

孟加拉国农村儿童肺炎的脉搏血氧测定法

• 批准号: 9119892
• 负责人: Eric Douglass McCollum
• 金额: $ 14.13万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119892
• 关键词: Age; Antibiotic Therapy; Antibiotics; Asia; Asians; Bangladesh; Bangladeshi; Biostatistical Methods; Breathing; Caring; Case Management; Cessation of life; Child; Child Care; Child health care; Childhood; Clinical; Clinical Investigator; Clinical Research; Collaborations; Communities; Community Health; Community Healthcare; Complication; Coughing; Country; Data; Decision Making; Developed Countries; Developing Countries; Diagnosis; Diagnostic; Enrollment; Epidemiology; Failure; Foundations; Funding; Goals; Health; Health Personnel; Healthcare; Heart Rate; Home environment; Hospitalized Child; Hospitals; International; Intervention Trial; Lead; Literature; Malawi; Measurement; Measures; Medical; Mentored Research Scientist Development Award; Mentors; Modeling; Monitor; Nutritional status; Oral; Outcome; Oxygen; Patients; Peripheral; Pneumococcal vaccine; Pneumonia; Public Health Schools; Pulmonology; Pulse Oximetry; Quality of Care; Recruitment Activity; Research; Research Design; Research Personnel; Resources; Respiration; Risk; Role; Rural; Science; Scientist; Severities; Severity of illness; Specialist; Technology; Temperature; Treatment Failure; Triage; Upper arm; Vaccination; Vaccines; World Health Organization; aged; base; diagnosis quality; experience; improved; instrument; international center; mortality; multidisciplinary; professor; programs; respiratory; skills; support tools; tool

DESCRIPTION (provided by applicant): This is a submission for a Fogarty International Center K01 International Research Scientist Development Award for Dr. Eric D. McCollum, a pediatric pulmonologist at the Johns Hopkins Eudowood Division of Pediatric Respiratory Sciences. Dr. McCollum is a junior clinical investigator in the field of childhood respiratory illnesses in low-resource countries. This K01 award will provide Dr. McCollum with the support needed to achieve the following objectives: (1) to become an expert in clinical research implementation and management in Asian resource-limited settings; (2) to develop skills in advanced study design and biostatistical methods; and (3) formulate multidisciplinary, long-distance collaborations with pediatric pulmonologists. To accomplish these objectives, Dr. McCollum has crafted a mentoring team including a US primary mentor, Dr. Abdullah Baqui, Professor in the International Health Department of Johns Hopkins Bloomberg School of Public Health, an international leader of child health in low-resource Asian countries, and a Bangladesh primary mentor, Dr. Dipak Mitra, Assistant Scientist in the International Health Department of Johns Hopkins Bloomberg School of Public Health and a child health expert based in Bangladesh, as well as four co-mentors; Drs. Katherine O'Brien and Bareng Aletta Sanny Nonyane, experts in child respiratory epidemiology and analysis, respectively; and Drs. Pamela Zeitlin and William Checkley, both specialists in pulmonology. Pneumonia is the number one cause of childhood death globally as well as in Asia. Dr. McCollum's research will leverage the ongoing multicenter Pneumococcal Vaccine Impact study to evaluate pulse oximetry as a pneumonia diagnostic in the community care of rural Bangladeshi children (Aim 1) and to develop and validate a childhood respiratory illness severity score appropriate for community care in Asia (Aim 2). In Aim 1, Dr. McCollum will lead a team of lay community health workers (CHWs) in the enrollment of 1,500 rural Bangladeshi children sick with cough and/or difficulty breathing in order to assess whether a low oxygen saturation is associated with radiographic pneumonia. In Aim 2, Dr. McCollum will direct a team of CHWs to recruit 2,200 rural Bangladeshi children with World Health Organization-defined non-severe pneumonia in order to develop and validate a risk score predictive of oral antibiotic failure and appropriate for CHWs. The research described in this application will serve as the foundation for independent funding proposals for intervention trials using pulse oximetry in rural Asian community care programs as a diagnostic pneumonia tool and as a validated instrument to assess pneumonia severity.

描述（由申请人提供）：这是Fogarty国际中心K01国际研究科学家发展奖Eric D. McCollum博士的提交，约翰·霍普金斯·麦克库勒姆（Eric D. McCollum博士是低资源国家儿童呼吸道疾病领域的初级临床研究者。该K01奖将为McCollum博士提供实现以下目标所需的支持：（1）成为亚洲资源有限设置的临床研究实施和管理专家； （2）发展高级研究设计和生物统计学方法的技能； （3）与儿科肺科医生建立多学科的长距离合作。为了实现这些目标，麦科勒姆博士精心制作了一个指导团队，包括美国主要导师，约翰·霍普金斯·彭博公共卫生国际卫生局教授阿卜杜拉·巴基（Abdullah Baqui）孟加拉国的专家以及四个副官员；博士。 Katherine O'Brien和Bareng Aletta Sanny Nonyane，儿童呼吸道流行病学和分析专家；和博士。 Pamela Zeitlin和William Checkley，都是肺科专家。肺炎是全球和亚洲儿童死亡的第一大原因。 McCollum博士的研究将利用正在进行的多中心肺炎球菌疫苗影响研究中，以评估脉搏血氧症作为肺炎诊断症的肺炎诊断，以在孟加拉国乡村儿童的社区护理中评估（AIM 1）（AIM 1），并发展和验证儿童呼吸疾病的疾病严重性评分适合亚洲社区护理（AIM 2）。在AIM 1中，McCollum博士将领导一支外行社区卫生工作者（CHW）团队参加1,500名孟加拉国乡村的患有咳嗽和/或难以呼吸困难的儿童，以评估低氧饱和度是否与射线照相肺炎有关。在AIM 2中，McCollum博士将指示CHW团队招募2200名具有世界卫生组织定义的非重度肺炎的孟加拉国乡村儿童，以发展和验证对口服抗生素衰竭和适合CHW的风险评分。本申请中描述的研究将作为在农村亚洲社区护理计划中使用脉搏血氧症作为诊断性肺炎工具的独立资金提案的基础，并作为评估肺炎严重程度的经过验证的工具。