Dartmouth Lung Biology Center for Molecular, Cellular and Translational Research

达特茅斯肺生物学分子、细胞和转化研究中心

• 批准号: 8514218
• 负责人: Bruce A. Stanton
• 金额: $ 120.84万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514218
• 关键词: Award; Basic Science; Biological; Biological Sciences; Biology; Biotechnology; Businesses; Cause of Death; Cell Nucleus; Centers of Research Excellence; Chronic; Communicable Diseases; Development; Drug Industry; Environment; Extramural Activities; Faculty; Financial Support; Funding; Immunology; Island; Laboratories; Lead; Life; Lung; Lung diseases; Maine; Mentors; Molecular; National Institute of Allergy and Infectious Disease; Pharmacotherapy; Pilot Projects; Positioning Attribute; Principal Investigator; Pseudomonas aeruginosa; Request for Applications; Research; Research Personnel; Research Support; Resources; Respiratory Tract Infections; Strategic Planning; Time; Translational Research; Universities; Vermont; catalyst; cellular imaging; clinically relevant; drug discovery; innovation; interest; medical schools; meetings; microbiome; multidisciplinary; novel; pathogen; programs; public health relevance; respiratory; respiratory disease/disorder therapy; success; therapeutic development

DESCRIPTION (provided by applicant): This COBRE III application requests funding to complete the establishment of a free standing, nationally recognized Lung Biology Center (LBC) in the Geisel School of Medicine at Dartmouth. The proposed plan for COBRE III builds upon our successes during COBRE I and II during which time we assembled, from a nucleus of 6 faculty, a critical mass of 32 well funded, tenured and tenure-track principal investigators who conduct inter-/multi-disciplinary research on respiratory infectious diseases. Our LBC faculty share common interests in host-pathogen interactions, the respiratory microbiome, and in drug discovery and therapeutic development. To support the research of our faculty we established three LBC-specific research cores, including a: (1) Host-Pathogen Interaction Core, (2) Live-Cell Imaging Core and (3) Translational Research Core. All of our junior faculty project leaders in COBRE 1/11 have already obtained extramural funding, an impressive record of accomplishment in this funding environment. A COBRE III award will provide essential resources to facilitate the continued development ofthe LBC, provide vital resources to enhance inter/multidisciplinary basic science and translational research in respiratory infectious disease, and is an essential component of our research core business plan to be financially independent by 2018. COBRE III support will enhance the continued mentored development of our junior faculty, including those previously supported by COBRE l/ll, the expansion ofthe research cores and an enhanced Pilot Project Program, and will facilitate mentored, collaborative and/or translational research at Dartmouth. Together with a substantial, and longterm, commitment from Dartmouth and strong collaborative ties with investigators in the Lung Biology and Immunology COBRE programs at the University of Vermont (UVM), the Dartmouth Immunology COBRE, the Dartmouth Quantitative Biological Sciences COBRE, and the INBRE programs at UVM, Dartmouth and the Mt. Desert Island Biological Laboratory (MDIBL) in Maine, we are in an exceptionally strong position to continue to build upon our successes in research on host-pathogen interactions, the respiratory microbiome in CF, and in drug discovery and therapeutic development for respiratory infectious diseases.

描述（由申请人提供）：此 COBRE III 申请需要资金来完成在达特茅斯盖泽尔医学院建立独立的、国家认可的肺生物学中心 (LBC)。 COBRE III 的拟议计划建立在我们在 COBRE I 和 II 期间取得的成功的基础上，在此期间，我们从 6 名教员的核心中召集了 32 名资金充足、终身任职和终身任职的主要研究人员，组成了关键的群体，他们进行跨/多研究呼吸道传染病学科研究。我们的 LBC 教师在宿主与病原体相互作用、呼吸道微生物组以及药物发现和治疗开发方面有着共同的兴趣。为了支持我们教师的研究，我们建立了三个 LBC 特定研究核心，包括：(1) 宿主-病原体相互作用核心、(2) 活细胞成像核心和 (3) 转化研究核心。我们 COBRE 1/11 的所有初级教师项目负责人都已经获得了校外资助，这是在这种资助环境下取得的令人印象深刻的成就记录。 COBRE III 奖将为促进 LBC 的持续发展提供重要资源，为加强呼吸道传染病的跨/多学科基础科学和转化研究提供重要资源， 这是我们的研究核心业务计划的重要组成部分，旨在到 2018 年实现财务独立。COBRE III 支持将加强我们初级教师的持续指导发展，包括以前由 COBRE l/ll 支持的人员、研究核心的扩展以及增强的试点项目计划，并将促进达特茅斯的指导、合作和/或转化研究。加上达特茅斯的实质性和长期承诺以及与佛蒙特大学 (UVM) 肺生物学和免疫学 COBRE 项目、达特茅斯免疫学 COBRE、达特茅斯定量生物科学 COBRE 和 INBRE 项目的研究人员的牢固合作关系在 UVM、达特茅斯和缅因州的沙漠岛生物实验室 (MDIBL)，我们处于非常有利的地位，可以继续发展我们的在宿主与病原体相互作用、CF 呼吸道微生物组以及呼吸道传染病的药物发现和治疗开发方面的研究取得了成功。