Everyday Quality of Life in Blacks and Whites with Osteoarthritis

患有骨关节炎的黑人和白人的日常生活质量

基本信息

批准号：
9060843
负责人：
PATRICIA A. PARMELEE
金额：
$ 40.77万
依托单位：
UNIVERSITY OF ALABAMA IN TUSCALOOSA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-01 至 2019-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9060843
关键词：
Activities of Daily Living Address Adult Affect Affective Affective Symptoms African American Age American Arthritis Attention Biological Biological Factors Characteristics Chronic Disease Cognitive Data Degenerative polyarthritis Diagnosis Disease Distress Elderly Emotional Epidemiology Health Health Care Costs Health Status Individual Knee Knee Osteoarthritis Leisure Activities Longitudinal Studies Measures Methods Modeling Moods Not Hispanic or Latino Obesity Pain Participant Patient Self-Report Pattern Performance Personal Satisfaction Personality Persons Physicians Population Prevalence Procedures Process Psychological Factors Quality of life Race Research Risk Sampling Shapes Site Source Symptoms Telephone Textiles Time Variant Work actigraphy aged behavioral response biopsychosocial cognitive process coping disability emotional distress ethnic difference experience functional decline functional disability indexing insight mood symptom optimism psychologic racial and ethnic racial and ethnic disparities sex social

项目摘要

DESCRIPTION (provided by applicant): This research examines relationships among pain, everyday activities and mood states, and long-term quality of life among African American (AA; Black) and non-Hispanic White (NHW; White) older adults with osteoarthritis (OA) of the knee. Recent evidence suggests considerable divergence in the experience and effects of this potentially very debilitating disorder among AAs and NHWs. Unfortunately, there has been little in-depth research on racial/ethnic (R/E) differences previous work on racial/ethnic (R/E) disparities in basic experience of OA symptoms, and in the emotional impact of those symptoms and related disability. This research addresses that gap in a longitudinal study of OA pain, functional disability and emotional well-being of AAs and NHWs. Working from a biopsychosocial model, we shall use functional assessments, self-reports, and real-time assessments of activities, symptoms and mood states to construct a comprehensive view of how OA affects physical and emotional functioning. Specific aims are (1) to describe racial/ethnic differences in associations among pain, disability, and emotional well-being of persons with OA of the knee; (2) to identify origins of those differences in (a) biological factors such as disease process and general health, (b) social factors such as demographic characteristics, and (ii) psychological factors, including stable personal characteristics and transitory (within-day) affective, cognitive and behavioral responses to knee symptoms; (3) to use experience sampling methods (ESM) and actigraphy to investigate how racial/ethnic differences in global associations among pain, functional limitations and emotional distress are reflected in the daily lives of OA sufferers, and (4) to explore how the interplay of transitory (within-day) symptoms, activities and mood states influences long-term physical and emotional well-being. These aims will be achieved in a 5-year, multi- site project examining cross-sectional and longitudinal associations among demographic and health characteristics, OA-related pain and disability, restriction of everyday activities, and emotional well-being. A sample of 220 AA and 220 NHW adults aged 50+ with physician-diagnosed OA of the knee will complete a comprehensive baseline assessment tapping biological, psychological and social vulnerability to OA pain and its effects; objective functional limitations; pain; activity restriction, and emotiona distress. Immediately post- baseline, participants will complete a 7-day ESM procedure comprising actigraphic assessment of activity levels along with 4 daily telephone contacts to assess current symptoms, activities, and moods. One year later, participants will repeat all measures, including the ESM component, to capture changes in overall physical and emotional well-being as well as patterns of daily activity and moods. Resulting data will offer unprecedented insight into the global factors that differentiate AAs' and NHWs' experience of OA symptoms, and how daily experiences are concatenated to influence longer-term physical and emotional well-being.

描述（由申请人提供）：本研究探讨了患有骨关节炎的非裔美国人（AA；黑人）和非西班牙裔白人（NHW；白人）老年人的疼痛、日常活动和情绪状态以及长期生活质量之间的关系。 OA）的膝盖。最近的证据表明，AA 和 NHW 之间对于这种可能使人严重衰弱的疾病的经历和影响存在相当大的差异。不幸的是，关于种族/民族 (R/E) 差异的深入研究很少，之前的工作是关于 OA 症状的基本体验以及这些症状和相关残疾的情绪影响方面的种族/民族 (R/E) 差异。。这项研究弥补了对 AA 和 NHW 的 OA 疼痛、功能障碍和情绪健康的纵向研究中的这一空白。从生物心理社会模型出发，我们将使用功能评估、自我报告以及对活动、症状和情绪状态的实时评估来构建 OA 如何影响身体和情绪功能的全面视图。具体目标是 (1) 描述膝关节骨关节炎患者的疼痛、残疾和情绪健康之间的关系的种族/民族差异； (2) 确定 (a) 生物因素中这些差异的根源例如疾病过程和一般健康状况，(b) 社会因素，例如人口特征，以及 (ii) 心理因素，包括稳定的个人特征和对膝盖症状的短暂（一天内）情感、认知和行为反应； (3) 使用经验抽样方法 (ESM) 和体动记录法来调查疼痛、功能限制和情绪困扰之间的全球关联中的种族/民族差异如何反映在 OA 患者的日常生活中，以及 (4) 探索如何相互作用短暂（一天之内）症状、活动和情绪状态会影响长期的身体和情绪健康。这些目标将通过一个为期 5 年的多地点项目来实现，该项目检查人口和健康特征、OA 相关疼痛和残疾、日常活动限制以及情绪健康之间的横向和纵向关联。 220 名 50 岁以上 AA 和 220 名 NHW 成年人（经医生诊断为膝关节 OA）样本将完成全面的基线评估，了解 OA 疼痛的生物、心理和社会脆弱性及其影响；客观功能限制；疼痛;活动限制和情绪困扰。基线后，参与者将立即完成为期 7 天的 ESM 程序，包括活动水平的活动记录评估以及每日 4 次电话联系，以评估当前的症状、活动和情绪。一年后，参与者将重复所有措施，包括 ESM 部分，以捕捉整体身体和情感健康以及日常活动和情绪模式的变化。由此产生的数据将为区分 AA 和 NHW 的 OA 症状体验的全球因素提供前所未有的见解，以及日常体验如何串联起来影响长期的身体和情感健康。