Hand-held advanced functional imager for assessing local tissue oxygenation

用于评估局部组织氧合的手持式高级功能成像仪

• 批准号: 8881787
• 负责人: Roman Kuranov
• 金额: $ 15万
• 依托单位: WASATCH PHOTONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8881787
• 关键词: 3-Dimensional; Adhesions; Advanced Development; Anatomy; Angiography; Animal Model; Area; Biological Markers; Blood; Blood Transfusion; Blood Vessels; Blood flow; Caliber; Clinical; Code; Color; Communicable Diseases; Consumption; Decision Making; Devices; Diffuse; Discrimination; Disease; Erythrocyte Transfusion; Erythrocytes; Etiology; Evaluation; Eye; Hand; Hemoglobin; Hospitals; Image; Imaging technology; Immune; Immune System Diseases; Inflammatory; Injury; Inpatients; Lead; Letters; Location; Lung; Malignant - descriptor; Maps; Market Research; Marketing; Measurement; Measures; Mechanics; Methods; Microcirculation; Modality; Modeling; Modification; Monitor; Morbidity - disease rate; Mus; Nature; Near-Infrared Spectroscopy; Optical Coherence Tomography; Outcome; Oxygen; Oxygen Consumption; Patients; Performance; Phase; Physicians; Positioning Attribute; Procedures; Property; Recurrence; Relative (related person); Resolution; Risk; Scanning; Skeletal Muscle; Small Business Innovation Research Grant; Social Impacts; Spectrum Analysis; Technology; Testing; Time; Tissues; Transfusion; Uncertainty; Universities; absorption; abstracting; arteriole; clinically relevant; commercialization; cost effective; data acquisition; design; digital; improved; in vivo; indexing; innovation; innovative technologies; instrument; interest; mortality; photonics; portability; prototype; public health relevance; quantitative imaging; spectrograph; spectroscopic imaging; tissue oxygenation; tissue phantom; tool; venule

 DESCRIPTION (provided by applicant): We propose development of an advanced functional imager to assess red blood cell (RBC) transfusion. The prototype will be tested in a functional phantom during this SBIR Phase I project. The key features of the imager are the ability to quantify local tissue oxygenation with a handheld probe for easy tissue access. Our preliminarily market research indicates a strong demand for such instrument to help physicians effectively perform RBC transfusion, which is the most common inpatient hospital procedure. We hypothesize that non-invasive technology capable of providing repeated 3-D functional maps of tissue microvessels with diameters between 20-50 µm, where oxygen starts diffusing to the parenchymal tissues, will significantly decrease morbidity and mortality in RBC transfusion. Such technology has the potential to guide procedures by providing favorable information about optimal transfusion threshold, as well as evaluation of RBCs degradation with storage time and conditions. Current imaging technologies used to assess RBC transfusion include: Sidestream Dark Field (SDF), Orthogonal Polarization Spectral (OPS) and Near Infrared Spectroscopy (NIRS) do not provide 3-D maps of microvascular blood oxygenation and flow in a single microvessel with diameter 20-50 µm. SDF and OPS provide 2-D non-depth-resolved angiography and blood flow microvasculature information, thus missing the oxygenation information and arterioles and venules discrimination. The NIRS provides average arterial oxygenation information from a few square mm area and thus misses oxygen extraction, blood flow and spatial resolution. We propose to fill this gap with the proposed imaging technology for RBC transfusion assessment by combining multifunctional optical coherence tomography (OCT) and OPS in a single hand- held device. OPS offers real-time 2-D microvasculature map for user guidance purposes while multifunctional OCT provides 3-D microvasculature angiography and maps of blood flow and hemoglobin oxygen (O2) saturation (SO2) in single arterioles and venules as well as O2 extraction and relative oxygen consumption. We believe our approach provides the needed performance to solve a critical problem and a clear path to successful commercialization. This project will have strong social impact by providing critical clinical information to improve patient outcomes. Quantitative imaging of local tissue oxygen delivery and consumption will not only improve RBC transfusion outcome but has a great potential to decrease morbidity and mortality in many devastating diseases with vascular etiology including a variety of malignant, inflammatory, ischemic, infectious and immune disorders.

 描述（由适用提供）：我们建议开发高级功能成像仪以评估红细胞（RBC）翻译。该原型将在此SBIR I期项目中在功能幻影中进行测试。成像仪的关键特征是能够使用手持探针量化局部组织氧合，以便于组织。我们的初步市场研究表明，对这种工具有效地有效地进行RBC输血的需求很强，这是最常见的住院医院手术。我们假设能够在20-50 µM之间进行直径的重复的3D功能图的非侵入性技术，其中氧气开始扩散到副群时正时，将显着降低RBC输血中的发病率和死亡率。这种技术有可能通过提供有关最佳输血阈值的优惠信息，以及对RBCS降级随存储时间和条件的评估，从而有可能指导程序。用于评估RBC输血的当前成像技术包括：侧stream暗场（SDF），正交极化光谱（OPS）和近红外光谱法（NIRS）不提供与二维为20-50 µm的单个微菌件中的微型血氧和流量的3-D图。 SDF和OPS提供了2-D非深度分辨的血管造影和血流微脉管信息的信息，因此缺少氧合信息以及小动脉和静脉区分。 NIRS提供了来自几个平方毫米面积的平均动脉氧合信息，因此错过了氧气提取，血流和空间分辨率。我们建议通过将多功能光学相干断层扫描（OCT）和单手设备中的多功能光学相干断层扫描（OCT）结合使用的RBC输血评估的提议的成像技术来填补这一空白。 OPS提供了实时的2D微举行图，用于用户指导目的，而多功能OCT提供了单个动脉和静脉以及O2提取和相对氧气和相对氧气的3-D微血管血管造影以及血流和血液流量和血红蛋白氧（O2）饱和度（SO2）的图。我们认为我们的方法提供了解决关键问题和成功商业化的清晰途径所需的绩效。该项目将通过提供关键的临床信息来改善患者预后，从而产生强烈的社会影响。局部组织氧递送和消耗的定量成像不仅会改善RBC的输血结果，而且具有降低许多具有血管病因的毁灭性疾病的发病率和死亡率的潜力，包括各种恶性，炎症，缺血性，缺血性，感染性和免疫学疾病。