Maternal Diabetes during Pregnancy and Neurodevelopment in the Offspring

妊娠期母亲糖尿病与后代神经发育

• 批准号: 8890396
• 负责人: Jasveer Virk
• 金额: $ 14.6万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-11 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8890396
• 关键词: Acceleration; Affect; Antioxidants; Area; Asses; Attention; Attention deficit hyperactivity disorder; Autistic Disorder; Autoimmunity; Behavior; Behavioral; Biological; Birth; Blood Glucose; Brain; Child; Chronic; Clinical; Cognition; Cognitive deficits; Cohort Studies; Collaborations; Data; Data Analyses; Denmark; Development; Diabetes Mellitus; Diagnosis; Disease; Environment; Environmental and Occupational Exposure; Epidemiology; Exposure to; Female of child bearing age; Fertility; Fetal Tissues; Free Radicals; Genetic; Gestational Diabetes; Glucose; Hospitals; Household; Hyperglycemia; Hyperinsulinism; Hypoxia; Impairment; Inflammation; Inflammatory; Insulin Signaling Pathway; Insulin-Dependent Diabetes Mellitus; Interferons; Interleukin-1; Interleukin-2; Interleukin-6; Investigation; Language; Lead; Link; Lipids; Measures; Medical; Memory; Mentored Research Scientist Development Award; Mentors; Military Personnel; Mothers; Motor Skills; Neurodevelopmental Impairment; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Outpatients; Performance; Population; Positioning Attribute; Pregnancy; Pregnancy in Diabetics; Pregnant Women; Process; Production; Reaction; Recording of previous events; Registries; Research; Research Support; Resources; Risk; Series; Source; System; Testing; Training; Universities; Variant; age group; autism spectrum disorder; base; biobank; cohort; cytokine; diabetes control; diabetes risk; experience; fetal; fetal programming; follow-up; glucose metabolism; inattention; insulin secretion; lipid metabolism; maternal diabetes; motor impairment; neurobehavioral; neurodevelopment; offspring; oxidation; prenatal exposure; prenatal risk factor; professor; public health relevance; repository; trait; trend; white matter

 DESCRIPTION (provided by applicant): This proposal builds on eight years of the candidate's previously conducted research on adverse prenatal exposures using the Danish Civil Registration System and Danish medical registers, and outcomes in the offspring. Through existing collaborations with Danish colleagues, the candidate has gained access and extensive experience with these unique, large-scale, nationwide registries. She now proposes to apply these resources to conduct the largest and most comprehensive study to date to examine the relationship between maternal diabetes and an array of neurodevelopmental outcomes that include markers of cognition, behavior, attention and motor skills. This application proposes a series of nationwide population cohort studies that will utilize the Danish Civil Registration System and Danish medical registers. It has the unique advantage of also incorporating a very large previously established cohort that is nested in the total population of Denmark and contains extensive maternal demographic histories in addition to household, environmental, and occupational exposures; this will inform the study on co-adversities in the fetal environment. Furthermore, another unique advantage of this study is the ability to asses an array of neurodevelopmental outcomes in the same population cohort, minimizing many sources of bias, and aiding the interpretation of these findings. This Mentored Research Scientist Development Award will be pursued within the context of a strong ongoing collaborative relationship between the UCLA Department of Epidemiology, Aarhus University and the UCLA Center for Autism Research and Treatment (CART). This application will provide training in neurobehavioral genetics so that the candidate can build a skillset compatible with analyzing data from large repositories available for research in the Nordic biobanks, and obtain depth in understanding of fetal programming of neurodevelopmental outcomes. Drs. Beate Ritz and Jorn Olsen have agreed to mentor the candidate through the K99 process. Dr. Dan Geschwind will oversee the candidate's training in neurobehavioral genetics, Dr. Diana Schendel will provide scientific and technical guidance on the project and Dr. Tania Esakoff will inform the project with her clinical experience in managing diabetes in pregnancy. The contents of this application provide a strategy to position the candidate such that she can launch successfully into a tenured professor track position, and gain the necessary experience to move towards independence and pursue R01 proposals.

 描述（由适用提供）：该提案建立在候选人先前使用丹麦民事注册系统和丹麦医疗注册的八年候选人进行的研究，以及后代的结果。通过与丹麦同事的现有合作，候选人在这些独特的大规模国家注册处获得了访问和丰富的经验。现在，她提议应用这些资源来进行迄今为止最大，最全面的研究，以检查母体糖尿病与一系列神经发育结果之间的关系，其中包括认知，行为，注意力，注意力和运动技能的标志。该申请提出了一系列全国人口队列研究，该研究将利用丹麦民事登记系统和丹麦医疗登记册。它具有独特的优势，即还增加了一个非常庞大的先前建立的队列，该队列嵌套在丹麦的总人群中，并且除了家庭，环境和职业暴露外，还包含广泛的孕产妇人口历史；这将为胎儿环境中共逆转的研究提供信息。此外，这项研究的另一个独特优势是能够在同一人群队中评估一系列神经发育结果，最大程度地减少许多偏见来源，并有助于对这些发现的解释。这项受过指导的研究科学家发展奖将在UCLA流行病学系，Aarhus大学和UCLA自闭症研究与治疗中心（CART）之间存在牢固的持续合作关系的背景下。该应用程序将在神经行为遗传学上提供培训，以便候选人可以建立与北欧生物库中可用于研究的大型存储库的分析数据相兼容的技能，并在理解神经发育结果的胎儿编程方面获得深度。博士。 Beate Ritz和Jorn Olsen已同意通过K99进程指导候选人。 Dan Geschwind博士将监督候选人在神经行为遗传学方面的培训，Diana Schendel博士将为该项目提供科学和技术指导，Tania Esakoff博士将以她在管理怀孕糖尿病方面的临床经验来为该项目提供信息。本申请的内容提供了一种策略来定位候选人，以便她可以成功地启动到终身教授的轨道职位，并获得必要的经验，以朝着独立性和购买R01提案迈进。