Developing a Smoking Cessation Intervention for Methadone Maintained Smokers

为继续使用美沙酮的吸烟者制定戒烟干预措施

基本信息

批准号：
8530195
负责人：
Nina Cooperman
金额：
$ 16.33万
依托单位：
RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8530195
关键词：
Abstinence Accounting Address Adherence Adult Adverse effects Aftercare Alcohol consumption Behavior Therapy Behavioral Cigarette Clinical Clinical Investigator Clinical Practice Guideline Complex Data Data Analyses Development Development Plans Drug abuse Drug usage Drug user Effectiveness of Interventions Elements Evaluation Focus Groups Foundations Future General Population Goals Guidelines Health Health behavior change Healthy People 2010 Illicit Drugs Individual Intervention Intervention Studies Learning Logistics Long-Term Effects Manuals Mental Health Mentorship Methadone Methodology Methods Modeling Motivation Nicotine Dependence Outcome Participant Patients Perception Persons Pharmaceutical Preparations Pharmacotherapy Physical Sufferings Population Prevalence Qualitative Research Randomized Clinical Trials Randomized Controlled Clinical Trials Randomized Controlled Trials Recommendation Relapse Research Research Methodology Risk Behaviors Science Self Efficacy Smoke Smoker Smoking Smoking Cessation Intervention Social support Staging Statistical Methods Stress Structure Symptoms Therapeutic Studies Tobacco Tobacco Dependence Tobacco Use Cessation Tobacco Use Epidemiology Tobacco smoking Tobacco use United States United States National Institutes of Health United States Public Health Service Withholding Treatment Writing alcohol abuse therapy base behavior change career development cigarette smoking coping drug abuser evidence base experience follow-up handbook information gathering interest meetings methadone clinic/center methadone maintenance mortality physical conditioning pilot trial primary outcome public health relevance reduce tobacco use research and development responsible research conduct skills smoking cessation symposium therapy development tobacco abstinence treatment program

项目摘要

DESCRIPTION (provided by applicant): Over 75% of drug abusers receiving methadone maintenance treatment are tobacco smokers. Methadone patients disproportionately suffer from the physical consequences of smoking, including increased mortality, compared to the general population. Yet, smokers receiving methadone treatment are interested in quitting and receiving tobacco cessation treatment, and drug abusing smokers who quit smoking are less likely to use drugs. The few studies of smoking cessation interventions in methadone patients have shown significant reductions in tobacco use during and immediately after treatment; however, the percentages of individuals who quit smoking were small and nearly all those who quit quickly returned to smoking. In addition, the interventions studied were simple and modeled after guidelines for the general population that may not have accounted for the complex needs of drug abusers. To better help methadone maintained smokers quit smoking and maintain tobacco abstinence, we propose a study with the following aims: (1) to determine the structure and elements of smoking cessation treatment that will help methadone maintained smokers quit smoking and maintain long-term tobacco abstinence; (2) to develop a manual for a tailored, intensive smoking cessation intervention for methadone maintained smokers; and (3) to pilot and evaluate in a small randomized controlled trial the immediate and long-term effects of a tailored, intensive smoking cessation intervention for methadone maintained smokers. This study will consist of two projects. Project One will address Aim 1 and involve collecting qualitative data through focus groups with methadone clinic clinical staff and current and previous smokers receiving methadone maintenance treatment. The data collected from Project One will inform Project Two, to develop and pilot in a small randomized controlled clinical trial a tailored, intensive smoking cessation intervention for methadone maintained smokers (Aims 2 and 3). My goal is to become an independent clinical investigator with expertise in smoking cessation, qualitative and quantitative research methods, and behavioral intervention development. The Career Development Plan I have proposed includes mentorship and structured coursework in: (1) qualitative research methods and data analyses; (2) behavioral intervention development and methods for smoking cessation; (3) methodology and logistics of conducting randomized clinical trials; (4) epidemiology of tobacco use; (5) advanced quantitative statistical methods; and (6) responsible conduct of research. In addition, I will participate in local seminars and national scientific meetings. PUBLIC HEALTH RELEVANCE: Reducing tobacco use and increasing smoking cessation attempts among adults are objectives of Healthy People 2010, and determining the effectiveness of interventions targeting persons with co- occurring risk behaviors was identified as a priority in the National Institutes of Health State-of-the- Science Conference Statement on Tobacco Use. We hope to help methadone maintained smokers quit smoking and maintain tobacco abstinence by developing and evaluating and new smoking cessation intervention.

描述（由申请人提供）：接受美沙酮维持治疗的吸毒者中有超过 75% 是吸烟者。与一般人群相比，美沙酮患者因吸烟而遭受的身体后果尤其严重，包括死亡率增加。然而，接受美沙酮治疗的吸烟者有兴趣戒烟并接受戒烟治疗，而戒烟的吸毒吸烟者使用毒品的可能性较小。对美沙酮患者进行戒烟干预的少数研究表明，治疗期间和治疗后立即吸烟量显着减少；然而，戒烟者的比例很小，而且几乎所有戒烟者很快又重新吸烟。此外，所研究的干预措施很简单，并且是根据针对普通人群的指南制定的，可能没有考虑到药物滥用者的复杂需求。为了更好地帮助美沙酮维持吸烟者戒烟并维持戒烟，我们提出一项研究，其目的如下：（1）确定戒烟治疗的结构和要素，以帮助美沙酮维持吸烟者戒烟并维持长期戒烟。 ; (2) 制定针对美沙酮维持吸烟者的量身定制的强化戒烟干预手册； (3) 在一项小型随机对照试验中试点和评估针对美沙酮维持吸烟者量身定制的强化戒烟干预措施的即时和长期效果。这项研究将包括两个项目。项目一将解决目标 1，并涉及通过美沙酮诊所临床工作人员以及接受美沙酮维持治疗的当前和既往吸烟者的焦点小组收集定性数据。从项目一收集的数据将为项目二提供信息，以在一项小型随机对照临床试验中为美沙酮维持吸烟者制定并试点一项量身定制的强化戒烟干预措施（目标 2 和 3）。我的目标是成为一名独立的临床研究者，拥有戒烟、定性和定量研究方法以及行为干预开发方面的专业知识。我提出的职业发展计划包括以下方面的指导和结构化课程：（1）定性研究方法和数据分析；（2）行为干预的发展和戒烟方法； (3) 进行随机临床试验的方法和后勤工作； (4) 烟草使用流行病学； (5)先进的定量统计方法； (6) 负责任地进行研究。此外，我还会参加当地的研讨会和国家科学会议。公共卫生相关性：减少成年人的烟草使用和增加戒烟尝试是《健康人 2010》的目标，确定针对同时发生危险行为的人群的干预措施的有效性被美国国立卫生研究院确定为优先事项。 - 关于烟草使用的科学会议声明。我们希望通过开发和评估新的戒烟干预措施，帮助美沙酮维持吸烟者戒烟并保持戒烟。