KRAS- and BRAF-Mediated Methylation Signatures in Colorectal Cancers and Polyps

结直肠癌和息肉中 KRAS 和 BRAF 介导的甲基化特征

• 批准号: nhmrc : 1050455
• 负责人: A/Pr Vicki Whitehall
• 金额: $ 30.48万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/kras-braf-mediated-cancers-polyps/112154
• 关键词: KRAS; BRAF; Mediated; Methylation; Signatures

Bowel cancer is one of the most common cancers affecting Australians. We hypothesise that there are different types of bowel cancer depending on different genes that can be inactivated abnormally, and these subgroups have different clinical features and responses to therapy. We aim to identify the major gene changes that characterise these subgroups, which will in the future allow the development of gene markers for early detection as well as the possibility of individualised patient therapy.

肠癌是影响澳大利亚人的最常见癌症之一。我们假设有不同类型的肠癌，具体取决于不同的基因可能会异常灭活，并且这些亚组具有不同的临床特征和对治疗的反应。我们旨在确定这些亚组的主要基因变化，这将来将允许开发基因标记以提早检测以及个性化患者治疗的可能性。