Exercise for Treatment of Relapse: Behavior and Neurobiology

运动治疗复发：行为和神经生物学

基本信息

批准号：
8590712
负责人：
Natalie Zlebnik
金额：
$ 3.13万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2014-07-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8590712
关键词：
AMPA Receptors Abstinence Address Aerobic Exercise Affect Animals Area Attenuated Behavior Behavior Therapy Behavioral Behavioral Mechanisms Behavioral Paradigm Biochemical Markers Biological Assay Brain Caliber Cell surface Cocaine Cues Dendritic Spines Drug abuse Drug usage Exercise Exhibits Extinction (Psychology)Extracellular Signal Regulated Kinases Female Glutamate Receptor Glutamates Goals Head Human Instruction Intake Intravenous Label Literature Mediating Modeling Molecular Morphology Neurobiology Neurons Nucleus Accumbens Pharmaceutical Preparations Pharmacological Treatment Phosphorylation Play Protein Analysis Proteins Public Health Rattus Relapse Research Rodent Role Running Self Administration Self-Administered Surface Synapses Techniques Testing Therapeutic Time Tissues Training Vertebral column Western Blotting Withdrawal Woman Work addiction behavior measurement cocaine exposure crosslink density design disorder later incidence prevention drug addict drug craving drug of abuse drug relapse drug seeking behavior insight male neuroadaptation neurobiological mechanism neuromechanism novel prevent public health relevance research study response sex therapy development trafficking transmission process treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Relapse to drug abuse is the single greatest problem in addiction treatment. Experimental evidence in humans and animals suggests that females are more prone to relapse than males, identifying a need for sex-specific treatment strategies for drug abuse. Aerobic exercise has emerged as an effective behavioral treatment for addiction, and studies suggest that it might be more effective to decrease drug abuse in females than males. The long-term goal of this project is to characterize exercise as a treatment for addiction in both males and females. The current aims are to examine the effects of aerobic exercise in male and female rats on relapse after a prolonged abstinence from drug use; determine whether exercise will reduce relapse-related neuroadaptations in brain areas important for addiction; and investigate differential effects of exercise in females vs. males. It is hypothesized that exercise will diminish relapse after prolonged abstinence, reverse or eliminate brain adaptations associated with prolonged abstinence, and act more effectively in females than in males. The experiments are designed to test the effects of voluntary wheel running in rats that are in prolonged withdrawal from intravenous cocaine self-administration, and the training potential of this project is to provide instruction in cellular and molecular experimental techniques paired with behavioral paradigms. To this end, behavioral measures, protein analysis, and neuronal morphology will be assessed. The proposed experiments have the potential to elucidate a novel sex-specific treatment for relapse and will give insight into the neurobiological mechanism of its action.

描述（由申请人提供）：药物滥用复发是成瘾治疗中最大的问题。人类和动物的实验证据表明，女性比男性更容易复发，因此需要针对药物滥用采取针对性别的治疗策略。有氧运动已成为治疗成瘾的有效行为疗法，研究表明，有氧运动可能比男性更有效地减少女性药物滥用。该项目的长期目标是将运动描述为男性和女性成瘾的治疗方法。目前的目标是检查雄性和雌性大鼠有氧运动对长期戒毒后复发的影响；确定运动是否会减少对成瘾很重要的大脑区域中与复发相关的神经适应；并研究运动对女性与男性的不同影响。据推测，运动会减少长期禁欲后的复发，逆转或消除与长期禁欲相关的大脑适应，并且对女性比男性更有效。这些实验旨在测试长期退出静脉注射可卡因自我给药的大鼠自愿轮跑的效果，该项目的培训潜力是提供与行为范式相结合的细胞和分子实验技术的指导。为此，将评估行为测量、蛋白质分析和神经元形态。拟议的实验有可能阐明一种新的针对复发的性别特异性治疗方法，并将深入了解其作用的神经生物学机制。