Neurobehavioral Characterization of Social Influence in Drug Addiction

吸毒成瘾的社会影响的神经行为特征

基本信息

批准号：
8827747
负责人：
Jodi Gilman
金额：
$ 18.6万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-15 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8827747
关键词：
Adolescent Adult Affect Age Alcohols Anterior Anxiety Area Award Behavior Behavioral Biological Biological Markers Biology Brain Brain imaging Clinical Complement Computers Conflict (Psychology)Data Set Decision Making Defect Development Drug Addiction Drug abuse Drug usage Education Environment Exhibits Expectancy Exposure to Functional Magnetic Resonance Imaging Gender General Hospitals Goals Health Hyperactive behavior Image Individual Individual Differences Insula of Reil Intervention Judgment K-Series Research Career Programs Laboratories Lead Learning Link Literature MRI Scans Maintenance Marijuana Massachusetts Mentors Methods Monitor Multimodal Imaging Neurobiology Neuropharmacology Neurosciences Nucleus Accumbens Patients Pharmaceutical Preparations Pharmacology Play Positioning Attribute Predisposition Process Productivity Psychiatry Psychological Tests Public Health Race Research Rewards Risk Role Running Scientist Series Social Psychology Staging Subgroup Substance Use Disorder Substance abuse problem Surveys Testing Tobacco Training United States Work addiction aged base behavior test bioimaging clinically relevant college computer program drug addict drug maintenance experience high risk improved individualized medicine innovation interest marijuana use medical schools neural circuit neural correlate neurobehavioral neuroeconomics neuroimaging neuromechanism peer peer influence psychologic relating to nervous system research study responsible research conduct reward circuitry skills social social group social learning social neuroscience social situation young adult

项目摘要

DESCRIPTION (provided by applicant): Dr. Gilman is currently a postdoctoral research fellow at Harvard Medical School (HMS) Department of Psychiatry and the Massachusetts General Hospital (MGH) Martinos Biomedical Imaging Center. The proposed K01 will provide her with advanced training and mentored research experience that will prepare her to establish an independent line of research examining the neuroscience of social decision-making in the context of substance abuse. Her goal is to direct a laboratory that uses multi-modal imaging and behavioral and psychological testing to understand the biological, psychological, and clinical aspects of drug abuse. Specifically, she is interested in using brain imaging to understand the role of social influence in different stages of drug use, to characterize individual differences in susceptibility to social influence, and to test if susceptibility to social influence is a risk facor for the development of substance use disorders. Advanced training with an exceptional mentoring team in a rich environment will enable her to advance to the next stage as an independent scientist. During the award period, Dr. Gilman will achieve the following aims: 1) Develop expertise in how social influence/group dynamics affect reward and decision-making processes, 2) Enhance understanding of the neurobiology/pharmacology of drug use, and integrate research into a clinical setting, 3) Increase her potential for independence by enhancing statistical training, developing advanced computer skills, and developing expertise in working with multi-modal data sets, and (4) Undertake specialized training in the responsible conduct of research. In the K01 period, Dr. Gilman will conduct an innovative project, Neurobehavioral Characterization of Social Influence in Drug Addiction, in which she will use a newly- developed social influence task to characterize behavior and neural correlates of social influence in early drug use. This K award will complement her existing strengths in neuroimaging, reward circuitry, and neuropharmacology, with training in social influence, neurobiology and clinical aspects of drug use, as well as in computer, statistical, and multimodal imaging skills, and will prepare her for an independent position as a productive addiction scientist.

描述（由申请人提供）：吉尔曼博士目前是哈佛医学院（HMS）精神病学系和马萨诸塞州综合医院（MGH）Martinos生物医学成像中心的博士后研究员。拟议的K01将为她提供高级培训和指导的研究经验，这将使她为在滥用药物滥用的背景下建立一个独立的研究范围，以研究社会决策的神经科学。她的目标是指导一个使用多模式成像以及行为和心理测试来了解药物滥用的生物学，心理和临床方面的实验室。具体而言，她有兴趣使用脑成像来了解社会影响在毒品使用的不同阶段的作用，以表征个体差异对社会影响力的敏感性，并测试对社会影响的敏感性是否是发展药物使用障碍的风险。在丰富的环境中，与卓越的指导团队进行的高级培训将使她能够成为独立科学家的下一阶段。 During the award period, Dr. Gilman will achieve the following aims: 1) Develop expertise in how social influence/group dynamics affect reward and decision-making processes, 2) Enhance understanding of the neurobiology/pharmacology of drug use, and integrate research into a clinical setting, 3) Increase her potential for independence by enhancing statistical training, developing advanced computer skills, and developing expertise in working with multi-modal data sets, and (4) Undertake specialized training in the responsible conduct of 研究。在K01时期，吉尔曼博士将进行一个创新的项目，即在吸毒成瘾中社会影响力的神经行为特征，在该项目中，她将使用新开发的社会影响任务来表征早期药物使用中社会影响的行为和神经相关性。该K奖将补充她在神经影像学，奖励电路和神经药理学中的现有优势，并在社会影响力，神经生物学和药物使用的临床方面以及计算机，统计和多模式成像技能方面进行培训，并将为她作为一名富有成效的成瘾科学家的独立位置做好准备。