Antimicrobial Coatings to Reduce Hospital Infections

抗菌涂层可减少医院感染

• 批准号: 8906076
• 负责人: GIRISH SRINIVAS
• 金额: $ 14.37万
• 依托单位: TDA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8906076
• 关键词: Address; Adherence; Adhesions; Affect; Alloys; American Type Culture Collection; Bacteria; Bed rest; Beds; Binding; Buffers; Catalysis; Cause of Death; Cell Wall; Cell membrane; Centers for Disease Control and Prevention (U.S.); Chelating Agents; Clinical Data; Clinical Research; Clinical Trials; Communicable Diseases; Copper; Corrosion; Deposition; Development; Diffuse; Disinfectants; Effectiveness; Electron Microscopy; Electrons; Electroplating; Enterobacter aerogenes bacterium; Environment; Enzymes; Epidemic; Escherichia coli; Escherichia coli O157; Escherichia coli O157:H7; Evaluation; Film; Government; Hand; Healthcare; Hospitals; Hydrogen Peroxide; Hydroxyl Radical; Hypochlorous Acid; Industrial fungicide; Infection; Insecticides; Intensive Care Units; Ion Channel; Ions; Legal patent; Long-Term Care; Malignant Neoplasms; Measures; Metals; Methicillin Resistance; Methods; Microbiology; Myocardial Infarction; Nosocomial Infections; Nurses; Organism; Oxidation-Reduction; Oxides; Ozone; Paint; Patients; Patients' Rooms; Persons; Phase; Preparation; Production; Property; Protocols documentation; Pseudomonas; Publishing; Quality of life; Rehabilitation therapy; Relative (related person); Reproduction spores; Research; Residual state; Resistance; Rest; Rodenticides; Roentgen Rays; Rupture; Sampling; Series; Side; Solid; Solutions; Spectrum Analysis; Stainless Steel; Staphylococcus aureus; Surface; System; Testing; Thick; Touch sensation; United States; United States National Institutes of Health; Virus; Water; X ray diffraction analysis; X-Ray Diffraction; antimicrobial; aqueous; arm; catalase; chlorine dioxide; combat; cost; cost effective; design; fungus; hatching; innovation; killings; meetings; methicillin resistant Staphylococcus aureus; microbial; microorganism; oxidation; pathogen; public health relevance; rapid growth; resistant strain; statistics; success; surfactant

 DESCRIPTION (provided by applicant): To combat Healthcare Associated Infection (HAI), which is now the 3rd leading cause of death in the U.S., TDA Research, Inc. proposes to develop new antimicrobial copper-alloy coatings for high-touch stainless-steel surfaces that may be responsible for 40% of all HAI. Low-cost, durable coatings will be scientifically designed for the catalytic production of hydroxyl radicals, *OH, which have the highest oxidation-reduction potential (2.76V) of any non-fluorinated species in water, surpassing that of all common disinfectants: ozone-2.076V, hydrogen peroxide-1.776V, hypochlorous acid-1.482V and chlorine dioxide-0.954V. The extreme oxidizing potential of hydroxyl radicals allows destruction of bacterial and fungal cell walls as well as spore and virus coatings. Copper provides a variety of other kill-mechanisms, including binding to microbial defensive enzymes including catalase. In moist environments, Cu1+ and Cu2+ ions diffuse and displace Na1+ and K1+ in cell- membrane ion channels, destroying their semi-permeable properties and causing microorganisms to rupture. Clinical trials unambiguously demonstrate that ~40% of Healthcare Acquired Infection in intensive-care units is eliminated by replacing only a few of the most frequently touched objects in patient rooms: bed side-rails, nurse call buttons, visitor-chair arm rests, over-bed tra tables and IV posts with pure copper. Further, the clinical data shows that copper retains antimicrobial activity in real-world hospital settings and is not deactivated by normal handling. Although proven extremely effective, replacing all hospital high-touch items with fixtures of solid copper is cost-prohibitive. Moreover, pure copper quickly corrodes and is too soft to resist abrasion. To address these issues, TDA Research, Inc. proposes to develop cost-effective methods to deposit thin films (~4µm thick) of copper alloys specifically onto existing stainless-steel surfaces that comprise roughly half of the high-touch surfaces prevalent in hospitals, but which possess little or no antimicrobial properties. The copper alloys will be developed for adhesion, resistance against corrosion and abrasion, ease of application, and will be doped to maximize the catalytic production of hydroxyl radicals. In Phase I, standard protocols required for the registration of anti-microbial copper under the Federal Insecticide, Fungicide and Rodenticide Act, will be followed explicitly. This involves testing of 1" x 1" coupons against the five pathogens: Staphylococcus aureus (American Type Culture Collection, ATCC 6538), a methicillin-resistant strain of S. aureus (ATCC 33592), pathogenic Escherichia coli O157:H7 (ATCC 35150), Enterobacter aerogenes (ATCC 13048) and Pseudomonas aeuginosa (ATCC 15442). As controls, uncoated stainless-steel, pure copper, and stainless-steel coated with pure copper will be tested. Phase I research will be considered a success if the microbial burden is reduced a minimum of 3log10 relative to uncoated samples as required by the standard protocol; simultaneously meeting ASTM Elcometer 107 scratch tests and a 5000-cycle Taber pumice/Cl1- corrosion/wear test (ASTM D-4060) to withstand an equivalent of 150,000 hand touches, while reducing costs.

 描述（由适用提供）：与医疗保健相关感染（HAI），现在是美国的第三大死亡原因，TDA Research，Inc。。提议开发新的抗微生物铜合金涂层，用于高脚触摸无钢表面，这些表面可能负责所有HAI的40％。低成本，耐用的涂料将是科学设计的，用于羟基自由基的催化生产， *OH，其在水中具有最高的氧化还原潜力（2.76V），它超过了所有常见的毒液，超过所有常见的毒液：ozone-2.076V，氢过氧化物1.776V，越过氧气酸，替代剂酸1.776v，cOODCERID-1.4888888888888888888888888888888888888888888888888888888888888888888888888太平洋。二氧化碳-0.954V。羟基自由基的极度氧化潜力允许细菌和真菌细胞壁以及孢子和病毒涂层破坏。铜提供了各种其他杀戮力学，包括与包括过氧化氢酶在内的微生物防御酶结合。在潮湿的环境中，Cu1+和Cu2+离子在细胞膜离子通道中扩散并置换Na1+和K1+，破坏其半渗透特性并导致微生物破裂。临床试验明确地表明，通过仅替换患者室中最常见的少数几个最常见的物体，即可消除约40％的医疗保健收到的感染：床侧障碍：护士呼叫按钮，访客椅子，访客椅子休息，过度的Tra tables和纯铜柱。此外，临床数据表明，铜保留在现实世界中医院环境中的抗菌活性，并且不会因正常处理而停用。尽管被证明非常有效，但用坚固的固定装置代替所有医院的高点式物品 铜的成本良好。此外，纯铜迅速腐蚀，太软而无法抵抗磨损。为了解决这些问题，TDA Research，Inc。提出提案，以开发具有成本效益的方法，以将薄膜（约4µm厚）的铜合金沉积到专门的不锈钢表面上，这些表面大约构成了医院中普遍存在的高触摸表面的一半，但它具有很小或不具有抗生素的物业。将开发铜合金以依从性，抵抗腐蚀和磨损，易于施用，并将掺杂以最大化羟基自由基的催化产生。在第一阶段，将明确遵循《联邦杀虫剂，杀菌剂和啮齿动物法》下抗菌铜所需的标准方案。这涉及对五种病原体的1“ x 1”券测试：金黄色葡萄球菌（美国型培养物收藏，ATCC 6538），一种耐甲氧西林的金黄色葡萄球菌（ATCC 33592），致病性埃斯特里希菌大肠杆菌O157：ATCC 35150和EnobAcccccccccccy andccc 35150） Aeuginosa（ATCC 15442）。作为对照，将测试未涂层的不锈钢，纯铜和涂有纯铜的不锈钢。如果标准方案要求，相对于未涂层的样品，I阶段研究将被认为是成功的。只需遇到ASTM Elcometer 107刮擦测试和5000周期的Taber Pumice/Cl1-Corsosion/Wear Test（ASTM D-4060）即可承受相当于150,000的手动，同时降低了成本。