Bioinformatics Programs at Minority Institutions

少数群体机构的生物信息学项目

• 批准号: 8821629
• 负责人: ALEXANDER J ROPELEWSKI
• 金额: $ 48.75万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8821629
• 关键词: Base Sequence; Bioinformatics; Biology; Biomedical Research; Chemistry; Computer software; Data; Development; Discipline; Educational Curriculum; Educational Materials; Educational process of instructing; Environment; Faculty; Funding; Genomics; Goals; Grant; Institutes; Institution; Instruction; Internships; Learning; Mentors; Minority; Minority Participation; Minority-Serving Institution; Multimedia; Principal Investigator; Publications; Recruitment Activity; Research; Research Activity; Research Project Grants; Research Technics; Resources; Scientist; Series; Stream; Structural Protein; Students; Supercomputing; Teacher Professional Development; Techniques; Training; Work; base; biomedical resource; computer science; improved; multidisciplinary; programs; skills; symposium; tool

DESCRIPTION (provided by applicant): The goal of this project is to increase minority participation in biomedical research through an educational and research program that is formulated to assist minority serving institutions establishing bioinformatics programs ranging in size from a single course to a degree program. We will assist five primary partners that have established a sequence based bioinformatics course in developing a more extensive bioinformatics program consisting of multiple courses, degrees/certificates, publications and grant support. In addition, we will continue to assist in establishing initial courses with a rotating series of informal partners. We will also enhance our support with an online, educational computational center and learning environment. This center will facilitate educational initiatives with a stand-alone streaming set of multimedia modules covering critical bioinformatics concepts ranging from basic biology to advanced bioinformatics topics to applying bioinformatics software in optimal ways. In addition, the center will serve as a self paced interdisciplinary bioinformatics resource for students and faculty at minority serving institutions enabling bioinformatics resources to be accessed through an environment that provides educational support. Specifically we will achieve this goal through a four component program that includes: 1) Improving the curriculum at minority serving institutions by adding bioinformatics components into multiple courses and in multiple departments, and integrating bioinformatics into research projects. 2) A summer institute which trains faculty from minority serving institutions in bioinformatics teaching and research techniques. 3) An Online Educational Center and learning environment featuring online interdisciplinary teaching resources supplemented with multimedia modules, bioinformatics software and problem sets. 4) An eight week research internship focused on publishable research results. This four component program assists minority serving institutions by embedding aspects of bioinformatics into a broad swath of scientific disciplines in both coursework and research activities. RELEVANCE: This project assists minority scientists in making their research more effective and efficient by training them to make use of modern bioinformatics techniques to exploit the large amount of sequence, genomics, and protein structural data being generated in biomedical research.

描述（由申请人提供）：该项目的目标是通过教育和研究计划来增加少数族裔对生物医学研究的参与，该计划旨在帮助少数族裔服务机构建立规模从单一课程到学位课程的生物信息学项目。我们将协助五个已建立基于序列的生物信息学课程的主要合作伙伴开发更广泛的生物信息学项目，包括多个课程、学位/证书、出版物和拨款支持。此外，我们将继续协助一系列轮流非正式合作伙伴建立初步课程。我们还将通过在线教育计算中心和学习环境来加强我们的支持。该中心将通过一套独立的流媒体多媒体模块来促进教育活动，这些模块涵盖了从基础生物学到高级生物信息学主题，再到以最佳方式应用生物信息学软件的关键生物信息学概念。此外，该中心将为少数族裔服务机构的学生和教师提供自定进度的跨学科生物信息学资源，使生物信息学资源能够通过提供教育支持的环境获取。具体来说，我们将通过四个组成部分的计划来实现这一目标，其中包括：1）通过将生物信息学成分添加到多个课程和多个部门中，并将生物信息学整合到研究项目中，改进少数族裔服务机构的课程。 2) 暑期学院，对少数民族服务机构的教师进行生物信息学教学和研究技术培训。 3）在线教育中心和学习环境，以在线跨学科教学资源为特色，辅以多媒体模块、生物信息学软件和问题集。 4) 为期八周的研究实习，重点关注可发表的研究成果。这个由四个部分组成的计划通过将生物信息学的各个方面嵌入到课程作业和研究活动的广泛科学学科中来帮助少数族裔服务机构。 相关性：该项目通过培训少数族裔科学家利用现代生物信息学技术来利用生物医学研究中产生的大量序列、基因组学和蛋白质结构数据，帮助他们提高研究的有效性和效率。

项目成果

An Optimization-Driven Analysis Pipeline to Uncover Biomarkers and Signaling Paths: Cervix Cancer.

• DOI: 10.3390/microarrays4020287
• 发表时间: 2015-06
• 期刊: Microarrays (Basel, Switzerland)
• 作者: Lorenzo E;Camacho-Caceres K;Ropelewski AJ;Rosas J;Ortiz-Mojer M;Perez-Marty L;Irizarry J;Gonzalez V;Rodríguez JA;Cabrera-Rios M;Isaza C
• 通讯作者: Isaza C

Draft Genome Sequence of New Bacillus cereus Strain tsu1.

新蜡样芽胞杆菌菌株 tsu1 的基因组序列草案。

• DOI: 10.1128/genomea.01294-14
• 发表时间: 2014
• 期刊: Genome announcements
• 作者: Li,Hui;Zhou,Suping;Johnson,Terrance;Vercruysse,Koen;Ropelewski,AlexanderJ;Thannhauser,TheodoreW
• 通讯作者: Thannhauser,TheodoreW

Multiple criteria optimization joint analyses of microarray experiments in lung cancer: from existing microarray data to new knowledge.

• DOI: 10.1002/cam4.540
• 发表时间: 2015-12
• 期刊: Cancer medicine
• 影响因子: 4
• 作者: Camacho-Cáceres KI;Acevedo-Díaz JC;Pérez-Marty LM;Ortiz M;Irizarry J;Cabrera-Ríos M;Isaza CE
• 通讯作者: Isaza CE

Evaluative profiling of arsenic sensing and regulatory systems in the human microbiome project genomes.

• DOI: 10.4137/mbi.s18076
• 发表时间: 2014
• 期刊: Microbiology insights
• 作者: Isokpehi RD;Udensi UK;Simmons SS;Hollman AL;Cain AE;Olofinsae SA;Hassan OA;Kashim ZA;Enejoh OA;Fasesan DE;Nashiru O
• 通讯作者: Nashiru O

Secondary Data Analytics of Aquaporin Expression Levels in Glioblastoma Stem-Like Cells.

• DOI: 10.4137/cin.s22058
• 发表时间: 2015
• 期刊: Cancer informatics
• 影响因子: 2
• 作者: Isokpehi RD;Wollenberg Valero KC;Graham BE;Pacurari M;Sims JN;Udensi UK;Ndebele K
• 通讯作者: Ndebele K