Center for Human Health and the Environment

人类健康与环境中心

• 批准号: 8841236
• 负责人: Robert C Smart
• 金额: $ 109.38万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-20 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8841236
• 关键词: Address; Animal Model; Back; Basic Science; Big Data; Bioinformatics; Biological; Biology; Cells; Centers for Population Health; Clinical; Communities; Community Outreach; Core Facility; Databases; Development; Development Plans; Discipline; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Epidemiology; Fostering; Funding; Future; Gap Junctions; Genes; Genome; Genomics; Goals; Grant; Health; Health Facility Environment; Health Sciences; Human; Individual; Interdisciplinary Study; Invertebrates; Knowledge; Leadership; Link; Molecular; Molecular Genetics; National Institute of Environmental Health Sciences; North Carolina; Organ Model; Outcome; Pathologic; Pathway interactions; Pilot Projects; Population; Population Sciences; Productivity; Proteomics; Public Health; Research; Research Personnel; Resources; Scientist; Services; Staging; System; Systems Biology; Technology; Tissues; Toxicogenomics; Training; Translating; Translational Research; Universities; Veterinary Pathology; Vision; base; career development; comparative; computerized tools; environmental stressor; epigenome; epigenomics; fundamental research; health science research; human disease; improved; instrumentation; laser capture microdissection; member; metabolomics; multidisciplinary; novel; prevent; programs; public health relevance; ranpirnase; research study; skills; success

 DESCRIPTION (provided by applicant) Through the purposeful interfacing of different disciplines and a systems biology framework integrating all levels of biological organization: biomolecule, pathway, cell, tissue, organ, model organism, human, and human population, the Center for Health and the Environment (CHHE) will elucidate fundamental mechanisms through which environmental stressors interface with pathways, the genome and epigenome to influence human health outcomes. CHHE will develop three interdisciplinary Research Teams that will integrate and build on NC State's unique research strengths and resources in quantitative biology and diverse model organisms as well as its emerging strength in human population science to advance discovery in environmental health sciences (EHS) along the continuum from genes to populations. The Molecular/Cellular-Based Systems and Model Organisms Team will utilize cutting-edge genetic/molecular/cellular-based systems and powerful vertebrate and invertebrate model organisms to conduct fundamental research to define mechanisms by which environmental exposures promote disease. The Human Population Science Team is composed of experts on environmental exposures, epidemiology, genomics, and epigenomics who are poised to identify key human pathways and link exposure and disease across populations. The Bioinformatics Team will develop novel computational tools and analytics to translate Big Data generated across high-throughput and multi-scale experiments into systems-level discoveries. The CHHE will develop three Facility Cores that will significantly increase the impact and the basic science and translational capacity of its Research Teams. One CHHE Facility Core will provide cutting-edge technologies involving proteomics, metabolomics and genomics along with dedicated bioinformatics support. A second Core will provide pathologic phenotypic assessment of the many model organisms used by CHHE members and provide laser capture microdissection service with links back to the "omics" technologies. The third Core, the Integrative Health Science Facility Core, will enable CHHE investigators to translate basic science discoveries to clinical and public health outcomes and vice versa. As a land-grant University, NC State has an extensive and active Cooperative Extension Service network throughout North Carolina. The CHHE will utilize this unique network to develop a highly effective, multi-directional Community Outreach and Engagement Core to disseminate findings and receive community input that will contribute to addressing disparities in exposures and health outcomes and to educate communities about environmental influences on health. A strong Career Development Core for early stage scientists that is coordinated with a robust Pilot Project Program will support cutting edge, collaborative, and multidisciplinary EHS projects to enhance the research success and impact of our membership. Through these activities and the interfacing of different disciplines, CHHE will build on NC State's unique research and community outreach strengths to become a premier transformative and synergistic EHS Core Center.

 描述（由申请人提供） 通过与不同学科的有目的接口和系统生物学框架整合了所有级别的生物组织：生物分子，途径，细胞，组织，组织，器官，模型 生物体，人类和人口，健康与环境中心（CHHE）将阐明基本机制，通过这些机制，环境压力与途径，基因组和表观基因组的互动以影响人类健康结果。 CHHE将建立三个跨学科研究团队，这些研究团队将在NC State定量生物学和多样化模型生物的独特研究优势和资源融合和建立，以及其在人群科学中的新兴实力，以推动环境健康科学（EHS）沿着基因的持续发展。基于分子/细胞的系统和模型生物团队将利用尖端的遗传/分子/细胞基系统以及强大的脊椎动物和无脊椎动物模型生物体进行基本研究，以定义环境暴露促进疾病的机制。人口科学团队由有关环境暴露，流行病学，基因组学和表观基因组学专家组成，他们被毒害以识别人类的关键途径，并将跨人群的暴露和疾病联系起来。生物信息学团队将开发新颖的计算工具和分析，以将高通量和多规模实验中生成的大数据转化为系统级别的发现。 CHHE将开发三个设施核心，这些设施将大大提高其研究团队的影响和基础科学和翻译能力。一个CHHE设施核心将提供涉及蛋白质组学，代谢组学和基因组学以及专用的生物信息学支持的尖端技术。第二个核心将对CHHE成员使用的许多模型生物提供病理表型评估，并提供激光捕获的显微解散服务，并链接回“ OMICS”技术。第三个核心是综合健康科学设施核心，将使研究人员能够将基础科学发现转化为临床和公共卫生结果，反之亦然。作为一所提供土地的大学，北卡罗来纳州立大学在整个北卡罗来纳州拥有广泛而积极的合作推广服务网络。 CHHE将利用这个独特的网络来开发一个高效，多方向的社区外展和参与核心，以传播发现并接收社区意见，这将有助于解决暴露和健康成果的分布，并教育社区对环境对健康的影响。早期阶段科学家的强大职业发展核心，与强大的试点项目计划协调将支持切割 Edge，协作和多学科EHS项目旨在增强我们的会员研究成功和影响。通过这些活动和不同学科的接触，Chhe将建立在NC State的独特研究和社区外展优势的基础上，成为最重要的变革性和协同性EHS核心中心。