DNA Repair in Chromatin: The First 40 years (and Beyond)

染色质的 DNA 修复：第一个 40 年（及以后）

• 批准号: 8911639
• 负责人: Michael J Smerdon
• 金额: $ 0.6万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-15 至 2016-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8911639
• 关键词: ADP ribosylation; Alkylating Agents; Anniversary; Apoptosis; Base Excision Repairs; Cells; Chromatin; Chromatin Structure; Chromosome Mapping; Clinical Pharmacology; Coupling; DNA; DNA Damage; DNA Packaging; DNA Repair; DNA Repair Gene; DNA Repair Pathway; DNA lesion; DNA repair protein; Epigenetic Process; Eukaryotic Cell; Excision Repair; Funding; Genes; Genetic Transcription; Genome; Heterogeneity; High Mobility Group Proteins; Higher Order Chromatin Structure; Histone Acetylation; Histone H2B; Histone H3; Histones; Human; Individual; Institutes; Lesion; Life; Maintenance; Malignant Neoplasms; Mammalian Cell; Molecular; Molecular Epidemiology; Mono-S; Mutation; National Institute of Environmental Health Sciences; Nuclear Proteins; Nucleosomes; Nucleotide Excision Repair; Organism; Participant; Pathway interactions; Photobiology; Play; Polymerase; Preparation; Publishing; Reactive Oxygen Species; Research; Rewards; Role; Scientist; Series; Signal Transduction; Site; Source; System; Time; Training; Transcription-Coupled Repair; Ultraviolet Rays; Universities; Variant; Washington; Work; assault; base; chromatin protein; chromatin remodeling; college; gene therapy; genome integrity; histone modification; human disease; interest; meetings; posters; programs; public health relevance; repaired; response; sensor; success; symposium

 DESCRIPTION (provided by applicant): This application is for partial funding of a special symposium, entitled "DNA Repair in Chromatin: The First 40 years (and Beyond)", to be held May 21-23, 2015, at Washington State University, Pullman, WA. This symposium will occur on the 40th anniversary of the first published work in this field. Approximately 75 participants are expected to attend, and there will be a mix of individuals from younger scientists, relatively new to the field, to some of THE world leaders in the field over the past 40 years. Maintenance of genomic integrity is fundamental to life. The genome is under constant assault by endogenous metabolites and environmental sources that damage the DNA molecule, giving rise to heritable changes in the sequence of genes. DNA repair pathways are 'molecular guardians' of genomic integrity and are one of the first lines of defense against a wide range of human diseases, including spontaneous and environmentally induced cancers. DNA repair in eukaryotic cells takes place in the context of chromatin where DNA, including damaged DNA, is tightly packed into nucleosomes and higher order chromatin structures. Chromatin intrinsically restricts accessibility of DNA repair proteins to the damaged DNA and impacts the overall rate of DNA repair. This symposium will focus on the role of DNA packaging on mechanisms and signaling of DNA repair of chemically and physically induced DNA damage by environmentally relevant agents (e.g., UV radiation, alkylating agents, and reactive oxygen species). Each session will have three to five speakers and sufficient discussion time to allow for substantial audience participation. Furthermore, this symposium will bring together scientists from seemingly divergent interests (e.g., chromatin structure, molecular epidemiology and DNA repair) who should add significantly to its overall success. In addition, a poster session will be available toall participants, allowing for additional new findings to be presented and discussed.

 描述（由应用程序提供）：本申请是为特殊研讨会的部分资金，标题为“染色质：前40年（及以后）的DNA修复”，将于2015年5月21日至23日在华盛顿州华盛顿州华盛顿州华盛顿州立大学举行。该研讨会将于该领域的首次发表作品成立40周年。预计将有大约75名参与者参加，并且在过去40年中，将会有一个来自该领域的年轻科学家，相对较新的人到该领域的一些领导者。基因组完整性的维持是生命的基础。该基因组受到损害DNA分子的内源代谢产物和环境源的持续攻击，从而导致基因序列的遗传变化。 DNA修复途径是基因组完整性的“分子监护人”，是针对广泛的人类疾病（包括赞助者和环保癌症）的最初防御线之一。真核细胞中的DNA修复发生在染色质的背景下，其中包括受损DNA在内的DNA被紧密地填充成核小体和高阶染色质结构。染色质将DNA修复蛋白的可及性限制在受损的DNA上，并影响DNA修复的整体速率。该研讨会将集中于DNA包装对机制的作用以及通过环境相关的药物（例如，UV辐射，烷基化剂和活性氧）的化学和物理诱导DNA损伤的DNA修复的信号传导。每个会议将有三到五位演讲者和足够的讨论时间，以允许大量观众参与。此外，该研讨会将从看似不同的利益（例如染色质结构，分子流行病学和DNA修复）中汇集科学家，这些科学家应该显着增加其整体成功。此外，还将提供海报会议，以提交参与者，从而提出和讨论其他新发现。