Plan for Cardiovascular Research Training in Advanced Biostatistics, Aging, and H

高级生物统计学、衰老和健康方面的心血管研究培训计划

• 批准号: 8336985
• 负责人: Dorairaj Prabhakaran
• 金额: $ 2.92万
• 依托单位: CENTRE FOR CHRONIC DISEASE CONTROL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-17 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8336985
• 关键词: Address; Aging; Appointment; Area; Award; Biometry; Cardiovascular system; Chicago; Chronic; Chronic Disease; Clinical Research; Collaborations; Communicable Diseases; Complement; Country; Data Collection; Demographic Transitions; Development; Diabetes Mellitus; Disease; Education; Endocrinology; Epidemiologic Studies; Epidemiologist; Equipment and supply inventories; Evaluation; Event; Faculty; Fellowship; Funding; Future; Grant; Health; Health Policy; Income; India; Institutes; Institution; International; International AIDS; Lead; Life; Light; Longevity; Mali; Medical; Medical Education; Medical Research; Mentors; Modeling; National Heart, Lung, and Blood Institute; Nigeria; Obesity; Postdoctoral Fellow; Preventive Medicine; Principal Investigator; Quality Control; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Training; Role; Science; Scientist; Site; Training; Training Programs; United States National Institutes of Health; Universities; cardiovascular disorder epidemiology; disorder control; experience; global health; health training; post-doctoral training; pre-doctoral; programs; research and development; responsible research conduct; success; surveillance data

Plan for Cardiovascular Research Training in Advanced Biostatistics, Aging, and Health Policy Modeling in India. DESCRIPTION (provided by applicant): The proposed application aims to develop and refine research training program activities for future pre- and post-doctoral research fellows from the Centre for Chronic Disease Control (CCDC) in New Delhi, India, in partnership with Northwestern University in Chicago, USA and All India Institute of Medical Sciences (AIIMS) in New Delhi, India in 3 target areas: 1) advanced cardiovascular biostatistics, 2) cardiovascular health and aging, 3) cardiovascular health policy modeling in order to apply for the Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43) during Year 2. The Objectives outlined above address strategic needs for CCDC and leverage existing, successful collaborations between CCDC, Northwestern, AIIMS, and their respective partner institutions. CCDC is a leading non-profit research institute India and is led by Dr. D. Prabhakaran (Principal Investigator on current D71 proposal). Dr. Prabhakaran, a cardiologist and epidemiologist, has extensive post- doctoral research training experience and is currently the Principal Investigator of the NHLBI/UnitedHealth- funded Global Center of Excellence in New Delhi. He is also the Site Director of the Fogarty International Clinical Research Scholars' and Fellows' Programs. The expansion of cardiovascular epidemiology funding and research in India has not been matched with a commensurate expansion of biostatistical training, a gap that will grow as data collection increases from many large epidemiologic studies in which CCDC either leads or participates. Research training in cardiovascular health and aging complements the current D43 grant at CCDC (D43 PI: Nikhil Tandon [consortium PD/PI on current D71 proposal]), which focuses on the role of early life events in the development of chronic diseases such as obesity and diabetes. The relationship between cardiovascular health and aging is particularly relevant in light of the predicted demographic transition in India. Cardiovascular health policy modeling research is also limited in low- and middle-income countries (LMIC), including India. While scientists call for evidence-informed policymaking, there is a dearth of cardiovascular health modeling that can provide guidance to policymakers when critical surveillance data are scarce. CCDC lacks expertise in these 3 target areas, and pre- and post-doctoral research training would address these needs. The Department of Preventive Medicine at Northwestern has a long track record of research and pre- and post-doctoral research training in these 3 target areas to help address these needs. Northwestern has also demonstrated successful training of post-doctoral fellows from the US, through its ongoing T32 training grant in cardiovascular epidemiology (T32 co-director: Dr. Kiang Liu [co-investigator on current D71 proposal]), and of fellows from LMIC (Dr. Liu). CCDC and Northwestern have demonstrated prior collaborative success through Dr. Mark Huffman's (collaborator) Fogarty International Clinical Research fellowship (co-mentors, Drs. D. Prabhakaran and Lloyd-Jones [consortium PD/PI on current D71 proposal]) and NIH K99/R00 grant. Dr. Robert Murphy, director of the Northwestern University Center for Global Health, has extensive experience in global health training as the PI of two NIH/Fogarty-funded programs: Medical Education Partnership Initiative (MEPI) in Nigeria (including a supplemental grant for training on the responsible conduct of research), AIDS International Training and Research Program (AITRP) in Nigeria and Mali. Dr. Murphy has a track record of successful international trainee education both in-country and at Northwestern, including support of 7 master's, 9 medium-term, and 223 short-term trainees. His expertise will be very helpful in planning a successful D43 proposal. AIIMS is India's premier medical research institute, and Dr. Tandon's appointments at both CCDC and the Department of Endocrinology and Metabolism at AIIMS will leverage his role as successful D43 PI with potential research trainees and infrastructure in New Delhi to create a competitive D43 application. Development of the research training components necessary to target these target areas (diverse faculty/trainee recruitment and retention, evaluation of appropriate didactic coursework, research project inventory, quality control/assurance training development, e.g.) will lead to a well thought-out D43 application in Year 2 of this D71 proposal between CCDC, Northwestern University, and AIIMS. The proposed D43 research training program will help fill key gaps in CCDC's current research capacity and further strengthen the collaboration between CCDC, Northwestern University, and AIIMS through the creation of a complementary, cross-connecting research program for Indian research trainees. Relevance Research capacity in advanced cardiovascular biostatistics, cardiovascular health and aging, and cardiovascular health policy modeling is lacking in India and in CCDC, in particular. As such, this proposal aims to strengthen the collaboration between CCDC, Northwestern, and AIIMS by creating an effective research training plan for a future D43 application in Year 2 to address these needs. PUBLIC HEALTH RELEVANCE: Cardiovascular (heart and vascular) diseases are the leading causes of death in India and typically afflict people at ages 10 years younger than in high-income countries. Recent increases in funding to research centers such as the Centre for Chronic Disease Control in New Delhi, India to study the distribution and determinants of cardiovascular diseases have not been matched by increases in local research capacity, especially in fields such as advanced cardiovascular biostatistics, cardiovascular health and aging, and cardiovascular health policy. We propose an international research training planning proposal to create a pre- and post-doctoral research training program, in partnership with Northwestern University in Chicago, USA, and the All India Institute of Medical Sciences in New Delhi, India to address these needs.

印度高级生物统计学、老龄化和健康政策建模心血管研究培训计划。 描述（由申请人提供）：拟议的申请旨在与西北大学合作，为印度新德里慢性病控制中心（CCDC）未来的博士前和博士后研究员开发和完善研究培训计划活动美国芝加哥和印度新德里的全印度医学科学研究所 (AIIMS) 的 3 个目标领域：1) 先进的心血管生物统计学，2) 心血管健康和老龄化，3) 心血管健康政策建模，以应用于慢性病,整个生命周期的非传染性疾病和失调：第 2 年福格蒂国际研究培训奖 (NCD-LIFESPAN) (D43)。上述目标满足 CCDC 的战略需求，并利用 CCDC、西北大学、AIIMS 和各自的合作机构。 CCDC 是印度领先的非营利性研究机构，由 D. Prabhakaran 博士（当前 D71 提案的首席研究员）领导。 Prabhakaran 博士是一位心脏病学家和流行病学家，拥有丰富的博士后研究培训经验，目前是 NHLBI/UnitedHealth 资助的新德里全球卓越中心的首席研究员。他还是福格蒂国际临床研究学者和研究员项目的网站主任。印度心血管流行病学资助和研究的扩大并未与生物统计培训的相应扩大相匹配，随着 CCDC 领导或参与的许多大型流行病学研究的数据收集的增加，这一差距将会扩大。心血管健康和老龄化方面的研究培训补充了 CCDC 当前的 D43 拨款（D43 PI：Nikhil Tandon [当前 D71 提案的 PD/PI 联盟]），该拨款重点关注早期生命事件在肥胖等慢性疾病发展中的作用和糖尿病。鉴于印度预计的人口转变，心血管健康与衰老之间的关系尤其重要。 心血管健康政策模型研究在包括印度在内的低收入和中等收入国家（LMIC）也很有限。尽管科学家呼吁制定基于证据的决策，但在关键监测数据稀缺时，缺乏可以为政策制定者提供指导的心血管健康模型。 CCDC 缺乏这 3 个目标领域的专业知识，博士前和博士后研究培训可以满足这些需求。 西北大学预防医学系在这 3 个目标领域的研究以及博士前和博士后研究培训方面拥有长期的记录，以帮助满足这些需求。西北大学还通过其正在进行的心血管流行病学 T32 培训资助（T32 联合主任：Kiang Liu 博士 [当前 D71 提案的联合研究员]）以及 LMIC 的研究员成功培训了来自美国的博士后研究员（刘博士）。 CCDC 和西北大学已通过 Mark Huffman 博士（合作者）Fogarty 国际临床研究奖学金（共同导师 D. Prabhakaran 博士和 Lloyd-Jones 博士[当前 D71 提案的 PD/PI 联盟]）和 NIH K99/ 展示了先前的合作成功R00 补助金。 Robert Murphy 博士是西北大学全球健康中心主任，作为 NIH/Fogarty 资助的两个项目的 PI，在全球健康培训方面拥有丰富的经验：尼日利亚的医学教育合作伙伴计划 (MEPI)（包括培训补充资助）关于负责任的研究行为），尼日利亚和马里的艾滋病国际培训和研究计划（AITRP）。墨菲博士在国内和西北大学拥有成功的国际实习生教育记录，包括支持 7 名硕士、9 名中期和 223 名短期实习生。他的专业知识对于规划成功的 D43 提案非常有帮助。 AIIMS 是印度首屈一指的医学研究机构，Tandon 博士在 CCDC 和 AIIMS 内分泌与代谢系的任命将利用他作为成功的 D43 PI 的角色，与新德里的潜在研究实习生和基础设施一起创建具有竞争力的 D43 应用。 开发针对这些目标领域所需的研究培训组件（多样化的教师/实习生招聘和保留、适当教学课程的评估、研究项目清单、质量控制/保证培训开发等）将导致深思熟虑的 D43 申请在 CCDC、西北大学和 AIIMS 之间的 D71 提案的第二年。拟议的 D43 研究培训计划将有助于填补 CCDC 当前研究能力的关键空白，并通过为印度研究实习生创建互补、交叉连接的研究计划，进一步加强 CCDC、西北大学和 AIIMS 之间的合作。 相关性 印度尤其是 CCDC 缺乏先进心血管生物统计学、心血管健康和老龄化以及心血管健康政策模型方面的研究能力。因此，该提案旨在通过为第二年的未来 D43 应用制定有效的研究培训计划来满足这些需求，从而加强 CCDC、西北大学和 AIIMS 之间的合作。 公共卫生相关性：心血管（心脏和血管）疾病是印度的主要原因，其发病年龄通常比高收入国家年轻 10 岁。最近，印度新德里慢性病控制中心等研究中心用于研究心血管疾病的分布和决定因素的资金增加，但当地研究能力的提高却未能与之相匹配，特别是在高级心血管生物统计学、心血管疾病等领域。健康与老龄化以及心血管健康政策。我们提出了一项国际研究培训规划提案，与美国芝加哥西北大学和印度新德里全印度医学科学研究所合作，创建博士前和博士后研究培训计划，以满足这些需求。