IGF::OT::IGF CHEMISTRY SERVICES FOR THE NATIONAL TOXICOLOGY PROGRAM

IGF::OT::IGF 国家毒理学计划化学服务

基本信息

批准号：
9033767
负责人：
RESHAN FERNANDO
金额：
$ 408.76万
依托单位：
RESEARCH TRIANGLE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-30 至 2016-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9033767
关键词：
Adverse effects Amniotic Fluid Analytical Chemistry Chemicals Chemistry Contracts Data Development Dose Drug Formulations Ensure Environmental Exposure Evaluation Exposure to Flame Retardants Goals Hazard Identification Hazardous Chemicals Health Heightened Cancer Risk Human Hypersensitivity Measures Methods National Toxicology Program Oral Outcome Plasma Rattus Risk Assessment Risk Factors Services Specific qualifier value Sprague-Dawley Rats Testing Tissues Toxic effect Toxicity Tests Toxicokinetics Validation disorder prevention fetal immunoregulation male programs public health research sound

Adverse effects Amniotic Fluid Analytical Chemistry Chemicals Chemistry Contracts Data Development Dose Drug Formulations Ensure Environmental Exposure Evaluation Exposure to Flame Retardants Goals Hazard Identification Hazardous Chemicals Health Heightened Cancer Risk Human Hypersensitivity Measures Methods National Toxicology Program Oral Outcome Plasma Rattus Risk Assessment Risk Factors Services Specific qualifier value Sprague-Dawley Rats Testing Tissues Toxic effect Toxicity Tests Toxicokinetics Validation disorder prevention fetal immunoregulation male programs public health research sound

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项目摘要

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of the heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and the development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals.

该项目的目的是提供国家毒理学计划（NTP）危害识别活动的支持，该活动针对预防疾病或由环境暴露于化学或物理剂引起的不良影响。毒性测试是公共卫生研究的重要方面，它有助于识别对人类健康有害的化学物质。需要进行适当的化学分析，以确保在毒性研究中，测试物种以指定的剂量浓度暴露于规定的化学物质。该合同通过提供所研究的化学物质的表征，对剂量水平的确认和内部剂量确定，有助于毒性研究提供癌症风险增加以及其他毒理学结果的证据。这些信息对于评估毒性测试和声音的发展至关重要，有关研究化学物质潜在毒性的科学结论，最终支持国家毒理学计划和其他联邦机构的风险评估工作。有了本合同提供的内部剂量信息，可以对人类进行外推，以便可以充分了解公众对研究化学物质的风险因素。