Brain Mechanisms Supporting Individual Differences in Pain

支持疼痛个体差异的大脑机制

基本信息

批准号：
8818530
负责人：
Robert C Coghill
金额：
$ 57.52万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8818530
关键词：
Acute Pain Address Affect American Anatomy Anxiety Biological Markers Brain Brain imaging Brain region Communities Complex Corpus striatum structure Data Data Set Databases Development Disease Economics Ensure Environment Ethnic Origin Evaluation Exhibits Factor Analysis Functional Imaging Future Heating Human Image Impulsive Behavior Impulsivity Individual Individual Differences Injury Insula of Reil Knowledge Link Magnetic Resonance Imaging Measures Mental Depression Mental Health Mental disorders Nociception Obesity Pain Pain intensity Parietal Lobe Participant Patients Pattern Phenotype Play Positioning Attribute Prefrontal Cortex Process Psychological Factors Psychological Tests Psychophysics Psychophysiology Publishing Recording of previous events Regression Analysis Reporting Research Role Rotation Sampling Sensory Sex Characteristics Shapes Solid Structure Techniques Testing Variant Work base chronic pain cingulate cortex cognitive control design ethnic difference experience morphometry neuroimaging neuromechanism physical conditioning psychologic public health relevance response sex socioeconomics treatment strategy volunteer

项目摘要

DESCRIPTION (provided by applicant): Both acute and chronic pain are associated with an incalculable toll in human suffering and present a significant economic problem. One of the major challenges in treating pain arises from the tremendous inter- individual variation in subjective reports of pain. Individuals with similar injuries will frequently report vastly differet experiences of pain. Such individual differences often result in inadequate treatment due to concerns about the validity or veracity of subjective reports of pain. Despite the profound clinica significance of individual differences in pain, remarkably little is known about the basic brain mechanisms that support such differences. Portions of this inter-individual variation in subjective reports of pain may be due to physical factors such as brain connectivity. Other components arise from psychological disposition and may involve factors such as cognitive control, impulsivity, depression, and anxiety. Finally, demographic variables such as sex and ethnicity may also substantially contribute to individual differences in pain sensitivity. Surprisingly littl is known about the brain mechanisms by which these factors influence the construction of the pain experience at the level of a single individual. Thus, the fundamental aim of the proposed research is to delineate the brain mechanisms that give rise to individual differences in pain sensitivity. We will acquire both functional and structural MRI data from a large number (392) of volunteers. Recruitment will be designed to obtain a true community sample in order to facilitate generalizability of findings. As such, this research will involve individuals of differing socio-economic levels, obese individuals, individuals with active depression and anxiety, as well as those in excellent physical and mental health. Participants will also undergo extensive sensory testing and psychological evaluation in order to fully characterize their pain phenotype. Multiple regression statistical analyses will be used to identify brain regions related to inter-individual differences in sensitivity in both structural and functional neuroimaging data. Techniques such as psychophysiological interaction analyses will be used to test hypotheses about the influence of functional connectivity on pain sensitivity. The identification of brain mechanisms that support individual differences in pain sensitivity will contribute substantially to our basic understandingof brain mechanisms of pain and will critically evaluate our existing notions that every individual processes nociceptive information in the same way. The results from the proposed studies will provide a solid rationale for the development of individualized pain treatment strategies.

描述（由申请人提供）：急性和慢性疼痛都与人类苦难的不可估量的损失有关，并带来了重大的经济问题。治疗疼痛的主要挑战之一是主观的疼痛报告中的巨大间隔。受伤相似的人经常报告疼痛的差异很大。由于担心主观疼痛的有效性或真实性，这种个体差异通常导致治疗不足。尽管疼痛中个体差异的临床意义很大，但对支持这种差异的基本大脑机制知之甚少。这个主观互生的部分差异疼痛的报告可能是由于身体因素（例如大脑连接性）所致。其他组成部分是由心理性倾向引起的，可能涉及诸如认知控制，冲动，抑郁和焦虑之类的因素。最后，性别和种族等人口统计学变量也可能导致疼痛敏感性的个体差异。令人惊讶的是，LITTL知道这些因素会影响单个个体水平的疼痛经历的构建的大脑机制。因此，拟议的研究的基本目的是描述引起疼痛敏感性个体差异的大脑机制。我们将从大量志愿者（392）中获得功能和结构MRI数据。招聘将旨在获得真正的社区样本，以促进发现的普遍性。因此，这项研究将涉及不同社会经济水平，肥胖的个体，积极抑郁和焦虑的人以及出色的身心健康的个人。参与者还将接受广泛的感觉测试和心理评估，以充分表征其疼痛表型。多元回归统计分析将用于识别与结构和功能神经成像数据中灵敏度之间与个体间差异相关的大脑区域。心理生理互动分析等技术将用于测试有关功能连通性对疼痛敏感性的影响的假设。识别支持的大脑机制疼痛敏感性的个体差异将有助于我们对疼痛的大脑机制的基本理解，并将批判性地评估我们现有的观念，即每个人都以相同的方式处理伤害性信息。拟议研究的结果将为发展个性化疼痛治疗策略的发展提供扎实的理由。