Hematopoiesis Training Grant

造血培训补助金

• 批准号: 8667028
• 负责人: J ERIC RUSSELL
• 金额: $ 34.9万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-20 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8667028
• 关键词: Grant; Hematopoiesis; Training

DESCRIPTION (provided by applicant): This application requests a renewal of the Hematopoiesis Training Grant, which was founded in 1999 to address the shortage in training opportunities for scientists and physician-scientists with career interests in hematopoiesis and hematopoietic stem cell biology; and to provide a core scientific leadership in this growing discipline for the next generation. The Hematopoiesis Program is a multi-disciplinary, cross-departmental training program that capitalizes on the extensive resources of the University of Pennsylvania School of Medicine (PSOM), The Children's Hospital of Pennsylvania (CHOP), and the Wistar Institute; selects appointees from pools of highly qualified trainees enrolled in their various pre- and post-doctoral programs; and encompasses faculty trainers with extensive funding, publication, and mentoring achievements. The Hematopoiesis Program has trained 17 post-doctoral and 5 pre-doctoral scientists with PhD, MD, or MD-PHD degrees, and currently accommodates an additional 3 post-doctoral and 3 pre-doctoral appointees. The Program draws pre-doctoral candidates from the large and highly regarded PhD and MD-PhD programs at the PSOM; and post-doctoral applicants from the competitive hematology fellowship programs at PSOM and CHOP, and from leading laboratories throughout the nation. Research mentorship is provided by 24 scientifically and experientially diverse trainers with research interests that encompass virtually all areas of hematopoiesis. The academic elements of the Program include an integrated curriculum of coursework, seminars, laboratory work, mentoring and career counseling, presentation, and manuscript and grant writing, which are effectively combined to train new investigators in the fundamentals of hematopoiesis science. Trainees are evaluated on the basis of written and oral presentations, Individualized Development Plans, and status conferences with the PI/PD and both research and Program mentors. The success of this instructional approach is indicated by the number of appointees who have progressed to leadership positions in academia and industry, have been successfully funded following Program graduation, and have made significant contributions to the biomedical literature. The Hematopoiesis Program underwent a change in leadership in 2011 following the death of its previous PI/PD, prompting a comprehensive review of programmatic goals and policy that have strengthened the training experience and are expected to impact future outcomes evaluation. The review also identified a large pool of highly qualified pre-doctoral MD-PhD students at Penn with career interests in hematopoiesis; consequently, this application requests two additional positions that are dedicated to these combined-degree students, to encourage and support their career progression in this area. In sum, the Hematopoiesis Program is carefully designed to train individuals in the fundamentals of hematopoiesis, with a goal of developing research leadership in this important and growing area of human biology.

描述（由申请人提供）：本申请要求续签造血培训补助金，该补助金成立于 1999 年，旨在解决对造血和造血干细胞生物学有职业兴趣的科学家和医师科学家的培训机会短缺问题；并为下一代在这一不断发展的学科中提供核心科学领导力。造血计划是一个多学科、跨部门的培训计划，利用了宾夕法尼亚大学医学院 (PSOM)、宾夕法尼亚儿童医院 (CHOP) 和 Wistar 研究所的广泛资源；从参加各种博士前和博士后项目的高素质学员中挑选被任命者；并包括拥有广泛资助、出版物和指导成就的教师培训师。造血项目已培养了17名博士后和5名博士前科学家，拥有博士学位、医学博士或MD-PHD学位，目前还容纳了另外3名博士后和3名博士前人员。该项目从 PSOM 大型且备受推崇的博士和医学博士项目中吸引博士前候选人；以及来自 PSOM 和 CHOP 竞争性血液学研究金项目以及全国领先实验室的博士后申请者。研究指导由 24 名科学且经验丰富的培训师提供，他们的研究兴趣几乎涵盖造血的所有领域。该计划的学术内容包括课程作业、研讨会、实验室工作、指导和职业咨询、演示以及手稿和资助写作的综合课程，这些内容有效地结合在一起，以培训造血科学基础知识的新研究人员。根据书面和口头演示、个性化发展计划以及与 PI/PD 以及研究和项目导师的状态会议对学员进行评估。这种教学方法的成功体现在许多被任命者已晋升为学术界和工业界的领导职位，在项目毕业后成功获得资助，并对生物医学文献做出了重大贡献。造血项目在其前任 PI/PD 去世后于 2011 年经历了领导层变动，促使对项目目标和政策进行全面审查，这些目标和政策加强了培训经验，预计将影响未来的结果评估。该审查还发现宾夕法尼亚大学有一大批高素质的博士前医学博士-博士生，他们对造血有职业兴趣；因此，该申请要求增加两个专门为这些联合学位学生提供的职位，以鼓励和支持他们在该领域的职业发展。总之，造血计划经过精心设计，旨在培训个人造血基础知识，目标是在人类生物学这一重要且不断发展的领域发展研究领导力。