Tribocorrosion in Modular Hip Joint Junctions-A Parametric Mechanistic Study

模块化髋关节连接处的摩擦腐蚀——参数化机制研究

• 批准号: 8594222
• 负责人: Mathew Thoppil Mathew
• 金额: $ 7.65万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-07 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8594222
• 关键词: Acceleration; Address; Adult; Adverse effects; Adverse event; Affect; Alloys; Appearance; Area; Arthritis; Behavior; Characteristics; Chemicals; Corrosion; Corrosives; Coupled; Couples; Coupling; Data; Drug Formulations; Environment; Equipment Malfunction; Equipment and supply inventories; Evolution; Failure; Female; Goals; Head; Head and neck structure; Health; Hip Joint; Hip Prosthesis; Hip region structure; Implant; Influentials; Injury; Investigation; Ions; Joints; Kinetics; Lead; Left; Life; Link; Longevity; Maps; Measurement; Mechanics; Medical; Metals; Mission; Modeling; Modernization; Motion; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Operative Surgical Procedures; Outcome; Pain; Pathway interactions; Patients; Principal Investigator; Process; Public Health; Reaction; Reporting; Research; Retrieval; Role; Series; Simulate; Solutions; Staging; Surface; Surgeon; Techniques; Testing; Tissues; Total Hip Replacement; Traumatic Arthropathy; United States; Variant; aged; base; cost; cost effective; design; disability; environmental change; expectation; flexibility; male; particle; prevent; programs; stem; successful intervention; synergism

DESCRIPTION (provided by applicant): Arthritis affects 50 million U.S. adults (most of whom are aged <65 years) with costs of $128 billion annually, and continues to be the most common cause of disability in the United States. By 2030, an estimated 67 million adults (one in four) are expected to be affected by arthritis. In severe cases, total hip replacements (THR) are accepted as a cost-effective and clinically successful intervention. A well functioning THR should be one that is durable (lasting for the duration of the patient's life) and enables the suffering patient o continue a normal life with minimum side effects on the host body. Currently, the average life span of a THR is estimated at 15 years most likely followed by multiple revision surgeries, particularly in the case of younger patients. One of the major concerns for metal-based hip implants is the loosening and subsequent failure of the femoral stem at the modular junction. The modular junction has been of serious concerns because of the coupled action of mechanical micro-motions (fretting) and the contact of two metals while in a corrosive environment that causes variations in the corrosion kinetics mainly due to galvanic coupling. Numerous surface analysis reports of retrieved metal implants have demonstrated evidence of fretting-corrosion at modular junctions. Previous studies on the fretting-corrosion of modular junctions reported the detrimental role of mechanically assisted corrosion (MAC) which is an unpredictable acceleration in the corrosion rates in association with mechanical wear. Hence, the synergistic approach of tribocorrosion that links tribology and corrosion is necessary to identify the pathways of failure at modular junctions. In this investigation the fundamental mechanisms influencing the tribocorrosion behavior of Ti and CoCrMo alloy in a simulated joint environment will be conducted. This technique will address the interaction between mechanical action, electrochemical degradation, metal ions and wear debris present at the modular junction interface. The objective in this application is to clearly define the potential mechanisms enabling the early failure of hip prostheses at the modular junction. We propose the following specific aims. Aim 1: Identify potential fretting regimes and the influence of pH level and load on the corrosion tendency. Aim 2: Study the electrochemical characteristics of the metal interface and the variability of the corrosion kinetics as a function of pH and load Aim 3: Develop a tribocorrosion synergistic model for Ti and CoCrMo alloys and identify the mechanistic transitions as a function of pH and fretting regime. It is expected that after the completion of ths project the failure mechanisms related to tribocorrosion will be determined and design improvements can be proposed to provide a safer modular junction that will assist the NIAMS mission of long-term solutions for the patients at a critical stage of arthritis. PHS 398/2590 (Rev 06/09) Page Continuation Format Page

描述（由申请人提供）：关节炎影响5000万美国成年人（其中大多数年龄在65岁之间），每年成本为1280亿美元，并且仍然是美国最常见的残疾原因。到2030年，估计有6700万成年人（四分之一） 预计将受到关节炎的影响。在严重的情况下，总髋关节置换（THR）被认为是一种具有成本效益且在临床上成功的干预措施。功能良好的THR应该是耐用的（持续在患者寿命的持续时间），并使苦难患者o继续正常生活，对宿主身体产生最小的副作用。目前，THR的平均寿命估计为15年，随后是多次修订手术，尤其是在年轻患者的情况下。金属髋关节植入物的主要问题之一是股骨茎在模块化连接处的松动和后续失败。由于机械微动物（折线）的耦合作用以及两种金属在腐蚀性环境中，导致腐蚀动力学的变化主要是由于电流偶联引起的，因此，模块化连接引起了严重的关注。许多检索金属植入物的表面分析报告证明了在模块化连接处的微分腐蚀的证据。先前关于模块化连接的微分腐蚀的研究报道了机械辅助腐蚀（MAC）的有害作用，这是与机械磨损有关的腐蚀速率的不可预测的加速度。因此，需要将摩擦学和腐蚀联系起来的互动腐败的协同方法对于确定模块化连接处的失败途径是必要的。在这项调查中，将在模拟的关节环境中影响Ti和Cocrmo合金的互动行为的基本机制。该技术将解决机械作用，电化学降解，金属离子和磨损界面处的相互作用。本应用程序的目的是清楚地定义实现的潜在机制 髋关节假体在模块化连接处的早期失败。我们提出以下特定目标。 AIM 1：确定潜在的颗粒制度以及pH值和负载对腐蚀趋势的影响。 AIM 2：研究金属界面的电化学特性以及腐蚀动力学作为pH和载荷的函数的变异性3：开发Ti和CoCRMO合金的互动协同模型，并识别机械过渡作为pH和pH和折线方案的函数。可以预期，在项目完成后，将确定与摩擦腐蚀相关的故障机制，并提出设计改进，以提供更安全的模块化连接，以帮助在关键的关键阶段为患者的NIAMS长期解决方案的NIAM任务。 PHS 398/2590（REV 06/09）页面延续格式页面