Cancer Biology

癌症生物学

基本信息

批准号：
8709571
负责人：
MICHAEL L CLEARY
金额：
$ 7.5万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-01 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8709571
关键词：
Angiogenic Factor Award Basic Science Biological Models Cancer Biology Cancer Center Cell Cycle Cell division Clinical Clinical Research Clinical Treatment Cytoskeleton DNA damage checkpoint Diagnosis Disease Epigenetic Process Epithelial Genome Stability Goals Grant Hematologic Neoplasms Humanities Interest Group Investigation Joints Journals Laboratories Link Malignant - descriptor Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of prostate Manuscripts Medicine Molecular Neoplasms Outcome Pathogenesis Pathway interactions Patients Peer Review Physiological Postdoctoral Fellow Publishing Regulation Research Research Activity Research Personnel Resource Sharing Role Schools Science Series Signal Pathway Signal Transduction Skin Cancer Subgroup Training Training and Education Translating Translational Research Translations Tumor Suppressor Genes United States National Institutes of Health Universities cell transformation cost effective graduate student improved interest medical schools meetings member neoplastic programs research study tumorigenesis

项目摘要

The Program in Cancer Biology is focused on investigations into mechanisms and signaling pathways involved in the malignant transformation of cells. The goals are to advance basic understanding of cancer pathogenesis and to translate basic science discoveries into the clinical arena to improve the outcome of patients with cancer. The Program encompasses three major thematic groups: 1) Mechanisms and Pathways of Oncogenesis; 2) Cell Cycle, Cytoskeleton and Genomic Stability; and 3) Epithelial Neoplasia (including skin, prostate and lung cancer subgroups). Investigations are focused on mechanistic studies of oncogenes and tumor suppressor genes, the control of cell division, genomic stability and DNA damage checkpoints, as well as disease-specific interests in hematologic malignancies, skin, prostate and lung cancers. The 40 investigators represent two different schools (the School of Medicine and the School of Humanities & Sciences), 16 Departments, and five Divisions within the Department of Medicine. The research activities of the 40 investigators are supported by 73 peer-reviewed, investigator-initiated grants (R01s and others), and five T32 training awards. Total NCI support is $4.3 million, other NIH support is $7.2 million, and non-NIH support is $3.2 million. Since 2005, program investigators have published over 400 manuscripts relevant to cancer biology in peer-reviewed journals. The Cancer Center will continue to be invaluable in assisting with the translation of the basic science findings from this Program into new clinical approaches for the diagnosis and treatment of patients with cancer.

癌症生物学项目重点研究机制和信号通路参与细胞的恶性转化。目标是增进对以下内容的基本理解癌症发病机制并将基础科学发现转化为临床领域以改善癌症癌症患者的结果。该计划包括三个主要主题组：1) 肿瘤发生的机制和途径； 2) 细胞周期、细胞骨架和基因组稳定性；和 3) 上皮肿瘤（包括皮肤癌、前列腺癌和肺癌亚组）。调查重点是癌基因和抑癌基因的机制研究、细胞分裂的控制、基因组学稳定性和 DNA 损伤检查点，以及血液学中特定疾病的兴趣恶性肿瘤、皮肤癌、前列腺癌和肺癌。这 40 名调查员代表两所不同的学校（医学院和人文科学学院），16个系，5个学部医学系。 40 名研究人员的研究活动得到 73 名同行评审的支持，研究者发起的资助（R01 和其他），以及五个 T32 培训奖。总NCI 支持金额为 430 万美元，其他 NIH 支持为 720 万美元，非 NIH 支持为 320 万美元。自从 2005年，项目研究人员在同行评审中发表了400多篇与癌症生物学相关的手稿期刊。癌症中心将继续为翻译提供宝贵的帮助该计划的基础科学发现转化为新的临床诊断方法和癌症患者的治疗。