Gordon Research Conference on "Infections of the nervous system: Pathogenesis and Worldwide Impact1"

戈登研究会议“神经系统感染：发病机制和全球影响1”

• 批准号: 8986297
• 负责人: SUSAN R ROSS
• 金额: $ 0.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8986297
• 关键词: Address; Affect; Animal Model; Arboviruses; Awareness; Bacterial Meningitis; Basic Science; Cell physiology; Cells; Cerebral Malaria; Cessation of life; Characteristics; Chikungunya virus; Clinical; Clinical Research; Collaborations; Communities; Country; Development; Diagnostic; Disease; Disease Outbreaks; Dourine; Fatal Outcome; Fellowship; Fostering; France; Functional disorder; Goals; Grant; HIV; Human; Immune; Immunology; Impairment; Infection; Infectious Agent; Insect Vectors; Institutes; Institution; International; Invaded; Investigation; Knowledge; Left; Location; London; Medical; Medical Research; Mission; Molecular; Molecular Genetics; National Institute of Neurological Disorders and Stroke; Nature; Nervous System Trauma; Nervous system structure; Neuraxis; Neurologic; Neurons; Oral; Organ; Outcome; Participant; Pathogenesis; Patients; Plague; Planets; Prevention; Primates; Principal Investigator; Rabies; Research; Research Personnel; Research Training; Resources; Rodent; Science; Scientist; Sensory; Series; Services; Singapore; Site; Societies; South Africa; Survivors; Therapeutic; Time; Toxoplasmosis; Training Programs; United Kingdom; Universities; Visit; West Nile virus; Work; adaptive immunity; base; burden of illness; cell motility; climate change; cognitive function; college; disease mechanisms study; drug discovery; global health; improved; lectures; man; meetings; member; multidisciplinary; nervous system disorder; nervous system infection; neurotropic; new technology; pathogen; patient oriented research; posters; prognostic tool; public health relevance; receptor; relating to nervous system; response; socioeconomics; success; symposium; therapy development; tool

 DESCRIPTION (provided by applicant): The burden of diseases caused by neurotropic pathogens often result in neurological sequelae that affect motility, sensory organs and cognitive functions in survivors. This in turn impairs socio-economic progress, especially in tropical regions where such diseases are particularly prevalent. With increasing manifestations of climate changes affecting our planet, pathogens spread by insect vectors may move to other regions, indicating how these pathogens have such a profound impact on neural cell function causing either a fatal outcome or debilitating, prolonged neurological impairment. As the central nervous system is usually not the primary target site of infection, a window of opportunity exists to interfere with pathogen spreading. It is crucial to develop therapies for neurological diseases that result in long lasting disease burden and impact on society. The Gordon Research Conference on "Infections of the nervous system", the 2nd of this series will advance knowledge in the field and promote exchanges between medical research centers in resource-rich and -poor regions. The format of GRC (community-based, small audience, focus on unpublished material) is ideal to create a multidisciplinary dialogue that will involve both clinicians and scientists studying disease mechanisms and host genetics, the molecular make-up of neurotropic infectious agents, and the innate and adaptive immune response to neurotropic pathogens. This series will bring together renowned clinicians and scientists, who investigate disease manifestations and molecular mechanisms underlying worldwide infections of the nervous system in humans that will further foster collaborations to accelerate investigations in the development of diagnostic/prognostic tools and pioneering therapeutics. The establishment of a strong community of top-ranked scientists working on infections of the nervous system will increase the awareness of world-leading research institutions on the impact and challenges in this field and foster new research and training programs in this topic. The conference will open with keynote lectures followed by scientific sessions that will address: how ways of invading the nervous system vary between pathogens; what are the specific neural target cells and their receptors for neurotropic pathogens; what are the characteristics of the immune and neural responses to invading pathogens; how clinical and pathogenesis studies can elucidate the nature of the nervous system damage caused by different pathogens; what are the new prospects for therapies and diagnostic in some of the diseases covered. Another important objective of this conference is to attract young researchers from all continents in the field. Thes trainees will present posters and/or short oral presentations, giving them ample time to discuss their work with the experts. Success of this grant will be instrumental in providing this opportunity to younger researchers to participant and contribute, thus advancing the mission of NINDS by expanding the knowledge on clinical and pathogenesis of devastating neurological diseases, and promoting progress in their prevention, diagnostic and therapies.

 描述（由适用提供）：神经性病原体引起的疾病的燃烧通常会导致神经后遗症影响运动性，感觉器官和存活中的认知功能。反过来，这会损害社会经济的进步，尤其是在这些疾病特别普遍的热带地区。随着气候变化影响我们地球的增长，病原体通过昆虫向量传播可能会移至其他区域，表明这些病原体如何对神经元细胞功能产生如此深远的影响，从而导致致命的结果或衰减，从而长期神经系统影响。由于中枢神经系统通常不是感染的主要目标部位，因此存在机会窗口以干扰病原体的扩散。开发有关神经系统疾病的疗法至关重要，从而导致持久疾病伯恩并对社会产生影响。戈登（Gordon）关于“神经系统感染”的研究会议，本系列的第二个将促进该领域的知识，并促进资源丰富和贫困地区的医学研究中心之间的交流。 GRC（基于社区，小观众，专注于未出版的材料）的格式是建立多学科对话的理想选择，该对话将涉及临床医生和科学家研究疾病机制和宿主遗传学，神经脊髓性传染性剂的分子构成，以及天生的和适应性免疫增强剂，对神经素的途径元基元基。该系列将汇集著名的临床医生和科学家，他们研究了人类神经系统世界感染的疾病表现和分子机制，这将进一步促进合作，以加快诊断/预后工具和先驱疗法的开发中的投资。建立一个牢固的高级科学家社区，致力于神经系统感染，这将提高对世界领先的研究机构对该领域的影响和挑战的认识，并在该主题中培养新的研究和培训计划。会议将以主题演讲开放，然后进行科学会议，这些会议将解决：入侵神经系统的方式如何在病原体之间变化；特定的神经元靶细胞及其受体是什么？免疫和神经对入侵病原体的反应是什么？临床和发病机理研究如何阐明由不同病原体造成的神经系统损害的性质；在某些疾病中，疗法和诊断的新前景是什么。这次会议的另一个重要目标是吸引来自该领域各大洲的年轻研究人员。学员将展示海报和/或简短的口头演讲，使他们有足够的时间与专家讨论他们的工作。这笔赠款的成功将有助于为年轻的研究人员提供参与和贡献的机会，从而通过扩大有关毁灭性神经系统疾病的临床和发病机理的知识以及促进预防，诊断和治疗方面的进步来推动NIND的使命。