Using CBT to Probe Psychobiobehavioral Resilience to Post-trauma Psychopathology

使用 CBT 探讨创伤后精神病理学的心理生物行为弹性

• 批准号: 8820735
• 负责人: Alyson Kay Zalta
• 金额: $ 15.38万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-25 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8820735
• 关键词: Academic Medical Centers; Adolescence; Adverse event; Allopregnanolone; Animal Model; Anxiety; Area; Behavioral; Behavioral Sciences; Biological; Biological Markers; Biological Sciences; Buffers; Chicago; Child Abuse; Childhood; Clinical; Clinical Trials; Cognitive; Commit; Complex; Conduct Clinical Trials; Control Groups; Data; Development; Distress; Environment; Event; Evidence based treatment; Exhibits; Extinction (Psychology); Failure; Future; Goals; Health education; Individual; Intervention; Intervention Studies; Knowledge; Lead; Link; Mental Health; Mental disorders; Mentors; Mentorship; Methods; Modification; National Institute of Mental Health; Neurobiology; Participant; Post-Traumatic Stress Disorders; Prevention program; Prevention strategy; Preventive Intervention; Process; Psychological Factors; Psychopathology; Qualifying; Randomized; Recording of previous events; Reporting; Research; Research Personnel; Research Training; Risk; Risk Factors; Scientist; Side; Social support; Stress; Symptoms; Testing; Time; Training; Translational Research; Trauma; Violence; Woman; Work; acute stress; analog; base; career; career development; conditioned fear; coping; dehydroepiandrosterone; depressive symptoms; design; emotion regulation; experience; follow-up; high risk; improved; learning extinction; men; neuropeptide Y; optimism; patient oriented; post intervention; prevent; programs; psychologic; public health relevance; resilience; response; skills; stress management; stressor; theories

 DESCRIPTION (provided by applicant): The PI's long-term career goal is to become an independent clinical scientist conducting translational research aimed at establishing risk and resilience processes associated with mental illness following trauma and developing preventive interventions that target these mechanisms. Risk and resilience to traumatic stress involves a complex interplay of psychological, biological, and behavioral processes; thus, the candidate aims to integrate neurobiology and behavioral science in the pursuit of this research program. This proposal outlines a training and research plan to achieve this goal, culminating in a successful R01 proposal. This plan takes full advantage of the candidate's strong institutional support and environment at Rush University Medical Center as well as a team of mentors, collaborators, and consultants with expertise in each of the critical training areas. The candidate's early focus has been in vulnerability mechanisms associated with anxiety. She also has experience with clinical trials research, biological markers of acute stress, and delivering evidence-based treatments for PTSD. The candidate seeks to build upon this skill set by pursuing training goals aimed at developing 1) expertise in risk and resilience to traumatic stress, 2) proficiency in conducting clinical trials, 3) a sophisticated understanding of the neurobiology of conditioned fear and responses to traumatic stress, and 4) mastery in conducing translational research that integrates biological and behavioral science. By synthesizing these training goals, the candidate will develop a unique patient-oriented career aimed at reducing the burden of trauma-related psychopathology through the development of translational preventive interventions. The research plan uses Stress Inoculation Training (SIT), a well-established cognitive behavioral stress management intervention, to probe risk and resilience mechanisms linked to post-trauma psychopathology. Ninety participants with a history of interpersonal trauma during childhood or adolescence and mild to moderate distress will be randomized to SIT or a health education control condition. The primary aims of this proposal are to examine whether individuals who receive SIT demonstrate increases in psychological resilience, biological resilience, and extinction learning compared to those in the control group. This proposal will also explore associations between these psychobiobehavioral risk and resilience factors. The specific aims of the proposal match well with the strategic goals of NIMH in that this study aims to explore dimensional processes of risk and resilience that cut across psychological disorders. By establishing the malleability of these risk and resilience candidates, the results of this study could have clinical utility in refining prevention strategies and will prepare the candidate to submit an R01 proposal examining the extent to which modification of underlying psychobiobehavioral risk and resilience mechanisms prevents psychopathology following future trauma exposure.

 描述（由适用提供）：PI的长期职业目标是成为一名独立的临床科学家进行翻译研究，旨在在创伤后建立与精神疾病相关的风险和韧性过程，并制定针对这些机制的预防性干预措施。对创伤压力的风险和韧性涉及心理，生物学和行为过程的复杂相互作用；因此，候选人的目的是在追求该研究计划时综合神经生物学和行为科学。该提案概述了实现这一目标的培训和研究计划，最终达到了成功的R01提案。该计划充分利用了Rush大学医学中心的候选人的强大机构支持和环境，以及在每个关键培训领域具有专业知识的导师，合作者和顾问团队。候选人的早期重点是与焦虑相关的脆弱性机制。她还拥有临床试验研究，急性压力的生物标记以及为PTSD提供循证治疗的经验。候选人试图通过追求旨在发展旨在发展创伤压力的风险和韧性专业知识的培训目标来建立这项技能，2）熟练度进行临床试验，3）对有条件的恐惧和对创伤性压力的神经生物学的复杂理解，以及对创伤性压力的反应，以及4）进行转化研究的精通，以整合生物学和行为科学。通过综合这些培训目标，候选人将开发一个独特的面向患者的职业，旨在通过发展转化预防干预措施来减少与创伤相关的心理病理学的燃烧。该研究计划使用压力接种培训（SIT），这是一种公认​​的认知行为压力管理干预措施，以探测与创伤后心理病理学相关的风险和弹性机制。在儿童或青少年期间有人际关系创伤史的90名参与者将被随机分配给坐姿或健康教育控制条件。该提案的主要目的是检查接受Sit的个人是否表现出与对照组相比的心理弹性，生物弹性和扩展学习的增加。该提案还将探讨这些精神ob虫的风险和弹性因素之间的关联。该提案的具体目的与NIMH的战略目标非常匹配，因为本研究旨在探索跨心理疾病的风险和韧性过程。通过建立这些风险和弹性候选者的锻造性，这项研究的结果可能具有临床实用性，可以使候选人做好准备提交R01提案，以研究基本的心理型疾病风险和弹性机制的修改的程度，以防止在未来的Treauma曝光下进行预防精神病学。