R21 'Regulated Morphogenesis of Human Sebaceous Glands'

R21“调节人类皮脂腺的形态发生”

• 批准号: 9095512
• 负责人: Steven T Boyce
• 金额: $ 14.38万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9095512
• 关键词: Anatomy; Area; Autologous; Burn injury; Cell Culture Techniques; Cells; Characteristics; Chimera organism; Coculture Techniques; Collaborations; Collagen; Dermal; Development; Disease; Doctor of Philosophy; Engineering; Environment; Epidermis; Fibroblasts; Gland; Goals; Growth and Development function; Hair; Hair follicle structure; Health; Human; Human Engineering; Immunodeficient Mouse; In Vitro; Injury; Knowledge; Life; Mesenchymal; Mesenchymal Stem Cells; Mesenchyme; Methods; Modeling; Monitor; Morbidity - disease rate; Morphogenesis; Mus; Natural regeneration; Patients; Physiology; Population; Qualifying; Regulation; Replacement Therapy; Research; Scalp structure; Sebaceous Glands; Signal Transduction; Skin; Skin Substitutes; Skin Tissue; Skin graft; Stem cells; Stimulus; Sweat Glands; Techniques; Testing; Therapeutic; Time; Tissue Engineering; Transplantation; Work; appendage; base; cell type; cellular engineering; design; keratinocyte; novel; progenitor; skin xenograft; stem; tongue papilla; wound

DESCRIPTION (provided by applicant): The goal of the proposed research is to establish methods for generating artificial epidermis for replacement therapies. Specifically, this project aims to determine the conditions to obtain skin grafts that include its normal appendages; the sebaceous glands and hair follicles. We have generated a novel method for culturing human primary sebaceous gland cells that maintain all the characteristics of sebocytes in vitro. The current project reflects an exciting new direction stemming directly from this work as we wish to use this technique to generate sebaceous gland in artificial epidermis.

描述（由申请人提供）：拟议研究的目标是建立用于替代疗法的人造表皮的生成方法。具体来说，该项目旨在确定获得包括正常附肢在内的皮肤移植物的条件；皮脂腺和毛囊。 我们已经开发出一种培养人类原代皮脂腺细胞的新方法，该方法在体外保持皮脂腺细胞的所有特征。当前的项目反映了直接源于这项工作的令人兴奋的新方向，因为我们希望使用这项技术在人造表皮中生成皮脂腺。

项目成果

Tissue engineering of skin and regenerative medicine for wound care.

• DOI: 10.1186/s41038-017-0103-y
• 发表时间: 2018
• 期刊: Burns & trauma
• 影响因子: 5.3
• 作者: Boyce ST;Lalley AL
• 通讯作者: Lalley AL