Sodium MRI of the Hip

髋关节钠 MRI

• 批准号: 8773239
• 负责人: Guillaume MADELIN
• 金额: $ 8.48万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8773239
• 关键词: Affect; American; Arthritis; Biochemical; Biochemical Markers; Cartilage; Chemicals; Chronic; Clinical; Coiled Bodies; Collagen Fiber; Complement; Concentration measurement; Cone; Data; Degenerative Disorder; Degenerative polyarthritis; Detection; Development; Diagnosis; Diagnostic Imaging; Diffusion; Diffusion Magnetic Resonance Imaging; Disadvantaged; Disease; Disease Progression; Early Diagnosis; Elderly; Etiology; Future; Gadolinium; Geometry; Glycosaminoglycans; Goals; Gold; Grant; Health; Heterogeneity; Hip Joint; Hip Osteoarthritis; Hip Pain; Hip region structure; Image; Imaging Techniques; Individual; Joints; Liquid substance; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Noise; Nuclear Magnetic Resonance; Pain management; Patients; Performance; Pharmaceutical Preparations; Physiologic pulse; Pilot Projects; Population; Prevalence; Protons; Publishing; Radial; Recovery; Relaxation; Replacement Arthroplasty; Research; Resolution; Risk; Scanning; Sensitivity and Specificity; Signal Transduction; Sodium; Sodium Channel; Speed; Synovial Fluid; Techniques; Time; Tissues; Water; articular cartilage; base; data acquisition; disability; follow-up; gadolinium oxide; healthy volunteer; high risk; imaging modality; improved; in vivo; magnetic field; novel; radiofrequency; reconstruction

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the most common form of arthritis in synovial joints and a leading cause of chronic disability, mainly in the elderly population. It currently affects 9% of the US population and is expected to affect 19% of Americans by 2030. OA is a degenerative disease of articular cartilage and is mainly characterized by a loss of glycosaminoglycans (GAG), change in size and organization of collagen fibers, and increased water content. There is no known cure for OA and present treatments focus mainly on pain management and ultimately, joint replacement. There are many obstacles to studying OA (heterogeneity in etiology, variability in progression of disease, long time periods required to see morphological joint changes), and consequently we currently lack the ability to predict the course of the disease. The limitation of identifying OA patients at riskfor progression and the lack of available non-invasive early biochemical markers have impeded the clinical development of potential disease modifying OA drugs (DMOAD). Specifically, hip osteoarthritis has a prevalence from 3 to 11% in Western population over 35 years old, and it is the main cause of hip pain in older adults. Quantitative sodium magnetic resonance imaging (MRI) is a non-invasive technique that is highly specific to the GAG content in cartilage that could be used to assess the degree of biochemical degradation of cartilage in OA. However, due to the low sodium concentration in vivo, its low sensitivity and fast relaxation, detecting the sodium signal in cartilage requires high fields (>3T), specific coils and specific 3D non-Cartesian sequences with ultrashort echo time. To the best of our knowledge, no study on sodium MRI of the hip was published to date. The recent acquisition of a dual-tuned body coil for imaging at 3T by our research team will allow us to acquire co-registered proton and sodium images of the hip within the same session. Quantitative sodium MRI could therefore provide a unique endogenous assessment of cartilage GAG content in clinically feasible scan times (20-25 min), and allow detection of OA in articular cartilage before morphological damage occurs and help assessing the effect of DMOAD treatments. The aims of this pilot study are: 1) to develop and optimize the acquisition and reconstruction of quantitative sodium MRI of the hip joint in vivo (to optimize the acquisition sequence parameters for minimizing the acquisition time, increasing the signal-to-noise ratio and spatial resolution, to measure relaxation times and B1 maps, and to optimize synovial fluid suppression) and, 2) to apply quantitative sodium MRI to subjects with and without hip OA (to assess repeatability, sensitivity, specificity of the method, with and without fluid suppression). This method could profoundly affect how we diagnose OA in the hip joint and may allow the identification of high risk individuals and also assess DMOAD treatment follow-ups. Successful completion of this pilot project would allow us to apply to a R01 grant for improving the speed of sodium data acquisition (using compressed sensing) and investigating the clinical value of quantitative sodium MRI for assessing different degrees of OA in comparison to other proton-based imaging techniques such as dGEMRIC, T1ρ mapping or diffusion imaging.

描述：骨关节炎（OA）是滑膜关节中最常见的关节炎形式，是慢性病的主要原因，主要是在老年人普及中。 。命令限制Proskfor进展的风险和可用的非侵入性早期生化KER的患者阻碍了西方Poption的临床发展的临床发展（DMOAD）。老年人。字段（> 3T），特定的线圈和特定的3D非卡提斯 迄今为止，髋关节的序列是我们的最佳序列。同一会话。体内（优化 采集时间的采集序列参数，信噪比和空间分辨率离子时间和B1映射，以及优化滑液抑制）和2）2）将定量钠MRI应用于有和没有嘻哈OA的受试者（评估评估）具有或没有流体的方法的重复性，灵敏度，特异性。与其他基于质子的成像技术（如DGemric，t1ρ映射或扩散成像）相比，授予了改善钠datata采集的传感钠的ED，并研究定量钠MRI评估OA学位的临床价值。