Cardiovascular Disease in Children with Chronic Kidney Disease
慢性肾病儿童的心血管疾病
基本信息
- 批准号:8497681
- 负责人:
- 金额:$ 17.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-07-01 至 2016-06-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingAcuteAdenosine TriphosphateAdultAreaArrhythmiaAwardBiological MarkersCardiacCardiomyopathiesCardiovascular AbnormalitiesCardiovascular DiseasesCardiovascular systemCause of DeathCessation of lifeChildChildhoodChronic Kidney FailureClinicalClinical ResearchClinical SciencesClinical Trials DesignCongenital Heart DefectsCoronary VesselsDeath RateDevelopmentDialysis procedureDiseaseEFRACEnergy MetabolismEpidemiologic StudiesEthicsFacultyFibrosisFrequenciesFunctional disorderFundingGoalsGrantHealthHeartHeart AtriumHeart DiseasesHeart HypertrophyHypertrophic CardiomyopathyHypertrophyInterventionIschemiaKidney TransplantationLeftLeft Ventricular HypertrophyMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaintenanceManuscriptsMaster of ScienceMeasurementMedialMedical centerMentored Patient-Oriented Research Career Development AwardMentorsMetabolismMethodologyMicroscopicMidcareer Investigator Award in Patient-Oriented ResearchMitral Valve InsufficiencyMorbidity - disease rateMuscleMyocardialMyocardial dysfunctionMyocardiumNephrologyPatientsPediatric HospitalsPeer ReviewPhosphocreatinePhysiologyPostdoctoral Individual National Research Service AwardPrevention programPropertyRenal Replacement TherapyResearchResearch MethodologyResearch PersonnelResearch Project GrantsResourcesRestrictive CardiomyopathyRoleSECTM1 geneScientistSecondary toSeveritiesSudden DeathTechniquesTechnologyTimeTrainingTraining ProgramsTranslational ResearchUnited States National Institutes of HealthUniversitiesVentricularWorkWritingadipokinesadiponectinbasecareerdesignexperienceinnovationinterestmortalitypatient oriented researchpressurepreventprogramssudden cardiac deathtranslational studyyoung adult
项目摘要
DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in children and young adults with chronic kidney disease (CKD). The applicant's long-term career goal is to define biologic targets for interventions to prevent and slow progression of CVD in children with CKD through advancing Patient-Oriented Research (POR). Since early years of his career, the applicant's research has been focusing on elucidating the mechanisms of cardiovascular abnormalities in children with CKD through epidemiological and translational studies. He has maintained continuous funding at the federal level in this area of research. He currently has an R01 examining the role of adiponectin and other adipokines in the development of cardiovascular abnormalities in children with CKD. Dr. Mitsnefes is also a Co-investigator and a Co-Chair of the Cardiovascular Committee for the NIH funded CKiD study (U01 mechanism), a multicenter effort designed to study children with CKD. The aim of this K24 program is to provide the candidate protected time and resources to build a comprehensive program to study CVD in children with CKD. Specific aims of this award are: 1) further the candidate's own research and 2) mentor junior faculty and fellows who are pursuing POR in pediatric nephrology. The first aim will be based and build upon candidate's previous research and will examine early biological markers of myocardial dysfunction in children on maintenance dialysis and after kidney transplantation: 1) left ventricular myocardial circumferential strain (Ecc), and 2) muscle energy metabolism by 31Phosphorus Magnetic Resonance Spectroscopy (31P MRS), and 3) left atrial size and markers of diastolic function. The second aim is based upon applicant's previous mentoring experience: since 2003 Dr. Mitsnefes has mentored 8 research fellows, and has been senior author on 17 peer-reviewed articles with his mentee as the first author. The Mentoring Plan for early career faculty and research fellows will incorporate the existing T32, K12 and K30 training programs at Cincinnati Children's Hospital Medical Center to produce outstanding clinical scientists who go on to be independent investigators. It will consist of: 1) individualized mentoring of 2 junior faculty who are planning to apply for K23 awards; 2) intensive practical training in patient-oriented research within the context of the current research projects of candidate's R01 for 2 fellows as well as development of their own independent research projects (F32 award); 3) course work in fulfillment of Master's of Science degree in the Graduate Program in Clinical and Translational Research at the University of Cincinnati; 4) participation of fellows in established other didactic programs on manuscript and grant writing, design of clinical trials and clinical research methodology, and ethics in clinical research. Cincinnati Children's Hospital Medical Center provides an ideal setting for this award because of the commitment to POR and ongoing initiatives to promote innovative clinical research through the presence of a strong Center for Clinical and Translational Science and Training.
描述(由申请人提供):心血管疾病(CVD)是慢性肾病(CKD)儿童和年轻人发病和死亡的主要原因。申请人的长期职业目标是通过推进以患者为导向的研究(POR)来确定干预措施的生物学目标,以预防和减缓 CKD 儿童 CVD 的进展。自职业生涯早期以来,申请人的研究一直致力于通过流行病学和转化研究阐明 CKD 儿童心血管异常的机制。他在这一研究领域一直获得联邦层面的持续资助。他目前正在进行一项 R01 研究,研究脂联素和其他脂肪因子在 CKD 儿童心血管异常发展中的作用。 Mitsnefes 博士还是 NIH 资助的 CKiD 研究(U01 机制)心血管委员会的联合研究员和联合主席,该研究是一项旨在研究 CKD 儿童的多中心项目。该 K24 计划的目的是为候选人提供受保护的时间和资源,以建立一个综合计划来研究 CKD 儿童的 CVD。该奖项的具体目标是:1) 进一步推进候选人自己的研究,2) 指导在儿科肾病学领域从事 POR 研究的初级教员和研究员。第一个目标将基于候选人之前的研究,并将检查维持性透析和肾移植后儿童心肌功能障碍的早期生物标志物:1) 左心室心肌周向应变 (Ecc),以及 2) 31 磷的肌肉能量代谢磁共振波谱检查 (31P MRS),以及 3) 左心房大小和舒张功能标志物。第二个目标是基于申请人之前的指导经验:自2003年以来,Mitsnefes博士已指导了8名研究员,并以他的导师为第一作者,成为17篇同行评审文章的资深作者。针对早期职业教师和研究员的指导计划将纳入辛辛那提儿童医院医疗中心现有的 T32、K12 和 K30 培训计划,以培养未来成为独立研究人员的杰出临床科学家。它将包括: 1) 对 2 名计划申请 K23 奖项的初级教师进行个性化指导; 2)在候选人R01当前研究项目的背景下,对2名研究员进行以患者为导向的研究的强化实践培训,以及开发自己的独立研究项目(F32奖); 3)完成辛辛那提大学临床和转化研究研究生课程理学硕士学位的课程工作; 4) 研究员参与已建立的其他教学项目,内容涉及手稿和拨款写作、临床试验设计和临床研究方法以及临床研究伦理。辛辛那提儿童医院医疗中心为该奖项提供了理想的环境,因为它致力于 POR 并通过强大的临床和转化科学与培训中心不断开展促进创新临床研究的举措。
项目成果
期刊论文数量(0)
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MARK M. MITSNEFES其他文献
MARK M. MITSNEFES的其他文献
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{{ truncateString('MARK M. MITSNEFES', 18)}}的其他基金
Cardiovascular Disease in Children with Chronic Kidney Disease
慢性肾病儿童的心血管疾病
- 批准号:
8027221 - 财政年份:2011
- 资助金额:
$ 17.08万 - 项目类别:
Cardiovascular Disease in Children with Chronic Kidney Disease
慢性肾病儿童的心血管疾病
- 批准号:
8262680 - 财政年份:2011
- 资助金额:
$ 17.08万 - 项目类别:
Adiponectin and Cardiovascular Disease in the CKiD Children
CKiD 儿童的脂联素与心血管疾病
- 批准号:
7315923 - 财政年份:2007
- 资助金额:
$ 17.08万 - 项目类别:
Adiponectin and Cardiovascular Disease in the CKiD Children
CKiD 儿童的脂联素与心血管疾病
- 批准号:
7766717 - 财政年份:2007
- 资助金额:
$ 17.08万 - 项目类别:
Adiponectin and Cardiovascular Disease in the CKiD Children
CKiD 儿童的脂联素与心血管疾病
- 批准号:
7677309 - 财政年份:2007
- 资助金额:
$ 17.08万 - 项目类别:
ABPM AND END ORGAN DAMAGE IN CHILDREN WITH RENAL TRANSPLANTATION
肾移植儿童的动态血压监测和终末器官损伤
- 批准号:
7374523 - 财政年份:2005
- 资助金额:
$ 17.08万 - 项目类别:
ABPM AND END ORGAN DAMAGE IN CHILDREN WITH RENAL TRANSPLANTATION
肾移植儿童的动态血压监测和终末器官损伤
- 批准号:
7203778 - 财政年份:2004
- 资助金额:
$ 17.08万 - 项目类别:
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