Risk Factors and Biomarkers for Diagnosis & Treatment of Eosinophilic Esophagitis

用于诊断的危险因素和生物标志物

基本信息

批准号：
8521269
负责人：
Evan Samuel Dellon
金额：
$ 18.04万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-15 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8521269
关键词：
Accident and Emergency department Aftercare Allergens Applications Grants Area Attention Award Basic Science Biological Markers Biology Biopsy Blood Cells Characteristics Chemotactic Factors Clinic Clinical Clinical Sciences Clinical Trials Consensus Control Groups Coupled Data Deglutition Deglutition Disorders Development Plans Diagnosis Disease Endoscopy Environment Eosinophilic Esophagitis Epidemiology Esophageal Esophageal Diseases Esophageal Stenosis Esophageal mucous membrane Food Funding Future Gastroenterologist Gastroesophageal reflux disease Goals Gold Guidelines Histologic Incidence Infiltration Institutes Interdisciplinary Study Interleukin-13 Internships Investigation Knowledge Lead Learning Measures Mediating Mentored Patient-Oriented Research Career Development Award Mentorship Methods Modeling Molecular Monitor Newly Diagnosed Pathogenesis Pathologic Pathology Patients Physicians Physiology Positioning Attribute Prevalence Principal Investigator Procedures Public Health Publications Receiver Operating Characteristics Research Research Methodology Research Personnel Research Proposals Research Technics Research Training Risk Risk Factors Scientist Series Serum Specimen Steroid therapy Steroids Techniques Testing Tissues Training Translational Research Work career career development chemokine clinical practice clinical risk cytokine diagnostic accuracy eosinophil gastrointestinal genetic risk factor human CCL26 protein improved infancy multidisciplinary novel patient oriented research planetary Atmosphere programs research and development response skills statistics treatment response

项目摘要

DESCRIPTION (provided by applicant): The candidate is a gastroenterologist with strong training in patient-oriented research methodology, and a proven commitment to the study of esophageal diseases, and eosinophilic esophagitis (EoE) in particular. The candidate's long-term career goal is to be an independently funded physician-scientist in the area of esophageal diseases leading a multidisciplinary translational research team bridging the clinic, endoscopy suite, pathology lab, and basic science lab. The candidate's short-term career goals for the K23 program are to: 1) acquire knowledge and skills in translational research techniques; 2) develop the professional skills to successfully lead a multidisciplinary research team; and 3) produce a critical mass of preliminary data and publications to support an R01 grant application and establish a program of independent research in EoE. The proposed research plan, career development activities, mentorship team, and institutional environment are all uniquely suited to assist the applicant in achieving these goals. The candidate's overall research goal is to better understand the epidemiology and pathogenesis of EoE in order to improve diagnosis and treatment. EoE is a rapidly emerging clinicopathologic entity defined by abnormal infiltration of eosinophils into the esophageal mucosa that leads to dysphagia, progressive esophageal stenosis, and food impaction. The specific goals of this research proposal are to validate our model of risk factors for diagnosis of EoE, and to assess the utility of serum levels of eotaxin-3 and IL-13 in diagnosis and monitoring of treatment of EoE. We will compare patients with newly diagnosed EoE to non-EoE controls, obtain baseline measures, reassess EoE patients after treatment, and also reassess untreated controls. The central premises to be tested are that: 1) clinical risk factors, coupled with non-invasive serum biomarkers, will lead to more accurate diagnosis of EoE; and 2) non-invasive biomarkers can be used to monitor treatment response. To support the candidate's career development, he will conduct a series of formal internships in selected basic science labs focusing on specific translational research techniques, as well as pursue advanced coursework and independent study in the areas of molecular techniques, biomarkers, and statistics as applied to public health and epidemiology. The mentorship and advising team, which includes internationally-recognized, independently-funded investigators with expertise in gastrointestinal epidemiology and translational team research (Sandler), esophageal diseases and translational research (Shaheen), cell and molecular physiology (Henning), and EoE pathogenesis and translational methods (Rothenberg), will guide Dr. Dellon's research and career development. The research environment including the Translational and Clinical Sciences Institute and Center for Gastrointestinal Biology and Disease at UNC provides a productive, collegial, and collaborative atmosphere in which to pursue the above research and training goals. At the conclusion of this program, Dr. Dellon will be positioned to be an independent physician-scientist leading a multidisciplinary translational research team.

描述（由申请人提供）：候选人是一位胃肠病学家，在以患者为导向的研究方法方面接受过严格的培训，并且对食管疾病，特别是嗜酸粒细胞性食管炎（EoE）的研究做出了可靠的承诺。候选人的长期职业目标是成为食管疾病领域的一名独立资助的医师科学家，领导一个连接诊所、内窥镜套件、病理实验室和基础科学实验室的多学科转化研究团队。 K23项目候选人的短期职业目标是：1）获得转化研究技术方面的知识和技能； 2）培养成功领导多学科研究团队的专业技能； 3) 提供大量的初步数据和出版物，以支持 R01 拨款申请并建立 EoE 独立研究计划。拟议的研究计划、职业发展活动、导师团队和机构环境都非常适合帮助申请人实现这些目标。候选人的总体研究目标是更好地了解 EoE 的流行病学和发病机制，以改进诊断和治疗。 EoE 是一种迅速出现的临床病理实体，其定义为嗜酸性粒细胞异常浸润食管粘膜，导致吞咽困难、进行性食管狭窄和食物嵌塞。本研究计划的具体目标是验证我们用于诊断 EoE 的危险因素模型，并评估血清eotaxin-3 和 IL-13 水平在诊断和监测 EoE 治疗中的效用。我们将把新诊断的 EoE 患者与非 EoE 对照进行比较，获取基线测量值，在治疗后重新评估 EoE 患者，并重新评估未经治疗的对照。待测试的中心前提是：1）临床危险因素与非侵入性血清生物标志物相结合，将导致更准确的 EoE 诊断； 2）非侵入性生物标志物可用于监测治疗反应。为了支持候选人的职业发展，他将在选定的基础科学实验室进行一系列正式实习，重点关注特定的转化研究技术，并在分子技术、生物标志物和统计学领域进行高级课程和独立研究。公共卫生和流行病学。指导和咨询团队包括国际公认的、独立资助的研究人员，他们在胃肠道流行病学和转化团队研究 (Sandler)、食道疾病和转化研究 (Shaheen)、细胞和分子生理学 (Henning) 以及 EoE 发病机制和转化方法（Rothenberg），将指导 Dellon 博士的研究和职业发展。包括北卡罗来纳大学转化与临床科学研究所和胃肠生物学与疾病中心在内的研究环境为实现上述研究和培训目标提供了高效、学院和协作的氛围。该计划结束后，Dellon 博士将成为一名独立的医师科学家，领导一个多学科转化研究团队。