Studies in Youths & Young Adults with Obesity & T2DM (07-DK-0115)

青少年研究

• 批准号: 8939596
• 负责人: MARC L REITMAN
• 金额: $ 40.14万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8939596
• 关键词: Adolescent; Adolescent and Young Adult; Adult; Affect; Age; Beta Cell; Biological Markers; Body Composition; Cardiovascular Diseases; Cell physiology; Child; Childhood; Complications of Diabetes Mellitus; Data; Diabetes Mellitus; Disease; Early identification; Failure; Functional disorder; Hormones; Individual; Insulin; Insulin Resistance; Life; Life Style; Measurement; Medical; Metabolic; Metformin; Methods; Morbidity - disease rate; Natural History; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Patients; Personal Satisfaction; Persons; Physiology; Pima Indian; Research Personnel; Risk Factors; Sleep; Sweetening Agents; Time; Validation; Youth; base; cardiovascular disorder risk; cohort; glucose metabolism; high risk; indexing; mortality; non-diabetic; offspring; psychologic; socioeconomics; type 2 diabetes in children; volunteer; young adult

Background Type 2 diabetes mellitus (T2DM) is a condition characterized by insulin resistance and progressive failure of the insulin-secreting beta-cells. Based on studies in small cohorts of young patients (especially Pima Indian offspring), we know that individuals with childhood onset T2DM are at very high risk for diabetes-related morbidity and mortality, due to a longer life-time duration of diabetes, as well as possible faster progression of beta-cell failure. Based on the currently largest available interventional trial, the TODAY study (Treatment Options for Diabetes in Adolescents and Youth), we know that standard medical treatment (metformin) is prone to fail in most patients. Our primary study objective is to acquire data on the natural history of T2DM in youth. Measurements will include indices of beta-cell function, body composition, cardiovascular disease risk factors, gut hormones, and psychological well-being. These data will be compared to findings in non-diabetic volunteers who are lean or overweight/obese. The study will also allow us to collaborate with other investigators in order to investigate factors (e.g. body composition changes, effect of life-style changes (such as sleep)) that determine the progression to and outcome of type 2 diabetes.

背景 2 型糖尿病 (T2DM) 是一种以胰岛素抵抗和胰岛素分泌 β 细胞进行性衰竭为特征的疾病。 根据对年轻患者（尤其是皮马印第安人后代）的小群研究，我们知道，由于糖尿病的寿命较长，患有儿童期 T2DM 的个体发生糖尿病相关发病率和死亡率的风险非常高尽可能加快β细胞衰竭的进展。根据目前最大的干预试验 TODAY 研究（青少年糖尿病的治疗选择），我们知道标准药物治疗（二甲双胍）对大多数患者来说很容易失败。 我们的主要研究目标是获取青少年 T2DM 自然史的数据。 测量内容包括β细胞功能、身体成分、心血管疾病危险因素、肠道激素和心理健康等指标。 这些数据将与瘦或超重/肥胖的非糖尿病志愿者的研究结果进行比较。这项研究还将使我们能够与其他研究人员合作，研究决定 2 型糖尿病进展和结果的因素（例如身体成分变化、生活方式改变（例如睡眠）的影响）。