Research and Development of Novel Drug Delivery Systems Symposium

新型给药系统研发研讨会

• 批准号: 8907150
• 负责人: Ram I. Mahato
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8907150
• 关键词: Academia; Address; Area; Award; Biological Products; Clinic; Clinical; Communities; Development; Dosage Forms; Dose-Limiting; Drug Delivery Systems; Drug Formulations; Drug Industry; Evaluation; Fees; Financial Support; Funding; Funding Opportunities; Hour; Individual; Industry; Knowledge; Manuscripts; Medical center; Minority; Minority Participation; Molecular Biology; Nanotechnology; Nebraska; Nucleic Acids; Oral; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacotherapy; Polymers; Postdoctoral Fellow; Property; Publications; Research; Research Personnel; Resistance; Review Committee; Role; Science; Scientist; Staging; Students; System; Technology; Therapeutic Agents; Translations; Travel; Underrepresented Minority; United States National Institutes of Health; Universities; Work; abstracting; base; bench to bedside; candidate selection; career; design; drug candidate; drug development; drug discovery; graduate student; high throughput screening; indexing; medical schools; multidisciplinary; nanomedicine; new therapeutic target; novel; novel therapeutics; posters; product development; professor; public health relevance; research and development; scale up; small molecule; symposium; targeted delivery; tool; undergraduate student; waiver

 DESCRIPTION (provided by applicant): High throughput screening and emergence of new therapeutic targets led to discovery of highly potent molecules with nanomolar efficacy. Clinical translation of the new therapeutic agents is limited by poor physicochemical and biopharmaceutical properties. To resolve this potential challenge, the need of the hour is the concerted effort by academia, pharmaceutical industry and regulatory body towards the development of novel delivery systems. Several new drug therapies fail due to non- selective drug disposition, poor accessibility to intracellular targets, dose limiting off target effects and resistance upon prolonged administration. These limitations can be potentially overcome through the development and scale up of novel drug delivery technologies. To expedite the translation of new molecules, the purpose of this conference is to share knowledge on drug product development principles among key players of pharmaceutical drug development, including representatives from academia, industry, and regulatory agencies. Participation from a diverse group of individuals including those representing minorities and traditionally underrepresented communities in science careers is expected. The two day symposium will include oral as well as poster presentations. Financial support provided for this conference will create opportunity to students to interact with top scientist in the field of drug delivery. In addition, registration fee waivers and travel awards will be provided to encourage participation by minorities and underrepresented communities. Based on the presentations and discussions at the conference, a manuscript will be prepared within 3 months after the conference and submitted for publication in a timely manner.

 描述（由应用提供）：高吞吐量筛查和新的治疗靶标的出现导致发现具有纳摩尔效率的高潜在分子。新治疗剂的临床翻译受到身体和生物药物特性差的限制。为了解决这一潜在的挑战，小时的需要是学术界，制药行业和监管机构为开发新型提供系统的一致努力。由于非选择性药物处置，对细胞内靶标的可及性不佳，剂量限制目标影响和 长时间给药的抵抗力。这些局限性可以通过新型药物输送技术的开发和扩展来克服这些局限性。为了加快新分子的翻译，本次会议的目的是分享药物开发主要参与者的药物开发原则的知识，包括代表学术界，工业和监管机构。预计，包括代表少数群体和传统代表人数不足的社区在内的科学生涯的人的参与。两天的研讨会将包括口头和海报演示。为这次会议提供的财政支持将为学生提供与药物交付领域顶级科学家互动的机会。此外，还将提供注册费用暖和奖，以鼓励少数民族和代表性不足的社区参与。根据会议上的演讲和讨论，会议结束后的3个月内将准备一个手稿，并及时提交出版。