Feasibility of Short-Term PrEP Uptake for MSM with Episodic High-Risk for HIV

具有偶发性 HIV 高风险的 MSM 短期接受 PrEP 的可行性

• 批准号: 8845287
• 负责人: KENNETH H MAYER
• 金额: $ 25.59万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8845287
• 关键词: AIDS prevention; Accounting; Address; Adherence; Alcohol or Other Drugs use; Biological Markers; Boston; Cities; Clinic; Data; Development; Dose; Effectiveness; Ensure; Ethnic Origin; Evaluation; HIV; HIV Infections; Health; Home environment; Incidence; Internet; Intervention; Interview; Measures; Methods; Minority Groups; Patient Self-Report; Pharmaceutical Preparations; Phase; Pilot Projects; Plasma Cells; Prevalence; Prevention strategy; Prophylactic treatment; Public Health; Race; Regimen; Reporting; Research; Research Activity; Risk; Risk Behaviors; Schedule; Site; Social Environment; Surveys; Time; Unsafe Sex; base; biobehavior; design; drug testing; effectiveness trial; efficacy trial; experience; high risk; men; men who have sex with men; prevent; programs; psychosocial; public health relevance; success; therapy design; tool; transmission process; uptake; willingness

 DESCRIPTION (provided by applicant): This proposed study is designed to investigate the acceptability, perceived need and uptake of short-term episodic Pre-Exposure Prophylaxis for HIV prevention among men who have sex with men (MSM). Long-term PrEP may be unnecessary for the many HIV-uninfected men who have episodic contextually defined high-risk periods, particularly when away from their home setting. Alternative dosing strategies, such as short-term fixed-interval episodic PrEP (Epi-PrEP), may be a more realistic, feasible, acceptable, and useful option with high public health impact for the majority of MSM. PrEP has the potential to dramatically raise the effectiveness of current HIV prevention efforts if it is correctly used and disseminated. This application is designed to investigate several questions essential to the development of efficacious Epi-PrEP uptake and adherence programs. The specific aims of the proposed two-city (Pittsburgh and Boston) study are to: (1) characterize and assess the prevalence of MSM who have high-risk but short-term periods when episodic PrEP may be an optimal HIV prevention strategy with a particular focus on low SES men; (2) determine the feasibility of clinic- based Epi-PrEP implementation pilot project for MSM who report occasional unprotected sex and who anticipate that they will have at defined high-risk time during the study period; and (3) Identify specific adherence-related contexts and problems, as well as resiliencies that will inform the intervention design of a larger scale trial of the effcacy of Epi-PrEP. Findings from this study will provide the empirical platform necessary to supporting the design, implementation and evaluation of an Epi-PrEP adherence intervention in a larger scale effectiveness trial. By basing the creation of new intervention strategies on data that measure both uptake and adherence of Epi-PrEP use among high-risk MSM, we can help ensure that PrEP strategies will reduce HIV transmission among the risk group that accounts for nearly two-thirds of all new HIV infections in the U.S.

 描述（由适用提供）：这项拟议的研究旨在研究与男性发生性关系的男性（MSM）中预防HIV预防的可接受性，感知需求和吸收。对于许多具有情节性上下文定义的高风险时期的艾滋病毒未感染的男人，尤其是在远离家庭环境时，可能是不必要的。替代剂量策略，例如短期固定间隔发作PREP（EPI-PREP），可能是更现实，可行，可接受且有用的选择，对大多数MSM的公共卫生影响很大。如果正确使用和传播，PREP有可能显着提高当前的HIV预防工作的有效性。该应用程序旨在调查有效的Epi-Prep摄取和依从性计划至关重要的几个问题。提议的两城市（匹兹堡和波士顿）研究的具体目的是：（1）表征和评估具有高风险但短期阶段的MSM的流行率，而情节性PREP可能是一种最佳的预防HIV预防HIV策略，其特定重点是低SES男性； （2）确定针对MSM的基于诊所的EPI-PREP实施试点项目的可行性，他们报告了偶尔的无保护性别，并预计他们将在研究期间定义的高风险时间； （3）确定与依从性相关的特定背景和问题，以及将为Epi-Prep的效率进行更大规模试验的干预设计的弹性。这项研究的发现将提供经验平台，以支持更大的规模有效性试验中的Epi-Prep依从性干预的设计，实施和评估。通过将新的干预策略的创建基于衡量高危MSM中EPI-PREP使用的吸收和遵守的数据，我们可以帮助确保PREP策略将减少占美国所有新艾滋病毒感染近三分之二的风险组中的HIV传播